hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07106.1
Complex Portal: CPX-13048
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MPDZ | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| AMOT | Angiomotin | 5 | UniProt NCBI |
| PALS1 | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | 5 | UniProt NCBI |
| AMOTL1 | Angiomotin-like protein 1 | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 7.35999422648e-15 | 0.833333333333 | PALS1 MPDZ AMOT AMOTL1 AMOTL2 | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| KEGG:04530 | 2.23152734084e-08 | 0.833333333333 | PALS1 MPDZ AMOT AMOTL1 AMOTL2 | Tight junction |
| GO:0043296 | 1.2932381028e-06 | 0.833333333333 | PALS1 MPDZ AMOT AMOTL1 AMOTL2 | apical junction complex |
| GO:0003365 | 1.92240082153e-06 | 0.5 | AMOTL2 AMOT AMOTL1 | establishment of cell polarity involved in ameboidal cell migration |
| GO:0005911 | 3.8574914383e-06 | 1.0 | PALS1 AMOT AMOTL1 AMOTL2 YAP1 MPDZ | cell-cell junction |
| REAC:R-HSA-2028269 | 6.83169380613e-06 | 0.5 | AMOTL2 AMOTL1 YAP1 | Signaling by Hippo |
| GO:0035329 | 4.39939518846e-05 | 0.666666666667 | AMOTL2 YAP1 AMOT AMOTL1 | hippo signaling |
| GO:0005923 | 0.000166466176189 | 0.666666666667 | AMOTL1 MPDZ AMOT AMOTL2 | bicellular tight junction |
| GO:0070161 | 0.000268529178236 | 1.0 | PALS1 AMOT AMOTL1 AMOTL2 YAP1 MPDZ | anchoring junction |
| GO:0070160 | 0.000359278119226 | 0.666666666667 | AMOTL1 MPDZ AMOT AMOTL2 | tight junction |
| CORUM:846 | 0.000477929626316 | 0.333333333333 | PALS1 AMOT | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| KEGG:04390 | 0.000989019592829 | 0.5 | PALS1 AMOT YAP1 | Hippo signaling pathway |
| GO:0007163 | 0.00921413838114 | 0.666666666667 | AMOTL1 AMOTL2 AMOT PALS1 | establishment or maintenance of cell polarity |
| GO:0030054 | 0.0120983352343 | 1.0 | PALS1 AMOT AMOTL1 AMOTL2 YAP1 MPDZ | cell junction |
| WP:WP4541 | 0.0451642815361 | 0.333333333333 | YAP1 AMOT | Hippo Merlin signaling dysregulation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PALS1 | AMOTL1 | 0.999 | 0.094 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| AMOTL2 | PALS1 | 0.999 | 0.04 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| YAP1 | AMOTL1 | 0.998 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| AMOTL2 | YAP1 | 0.997 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PALS1 | MPDZ | 0.996 | 0.052 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| YAP1 | AMOT | 0.996 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| YAP1 | PALS1 | 0.995 | 0.08 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| AMOT | AMOTL1 | 0.995 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| MPDZ | AMOTL1 | 0.991 | 0.078 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | MPDZ | 0.987 | 0.07 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| YAP1 | MPDZ | 0.984 | 0.022 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| AMOT | MPDZ | 0.983 | 0.0822222222222 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | AMOTL1 | 0.976 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PALS1 | AMOT | 0.973 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| AMOTL2 | AMOT | 0.268 | 0.206 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes