hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07112.1
Complex Portal: CPX-16283
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOR3A | Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) | 5 | UniProt NCBI |
| ITGB5 | Integrin beta-5 | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2846 | 0.0165527833611 | 0.333333333333 | PCSK9 | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.0165527833611 | 0.333333333333 | PCSK9 | Evolocumab mechanism to reduce LDL cholesterol |
| CORUM:2347 | 0.0499402709677 | 0.333333333333 | ITGB5 | ITGAV-ITGB5-SPP1 complex |
| CORUM:2350 | 0.0499402709677 | 0.333333333333 | ITGB5 | ITGAV-ITGB5 complex |
| CORUM:5712 | 0.0499402709677 | 0.333333333333 | ITGB5 | FAK-beta5 integrin complex, VEGF induced |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PCSK9 | TOR3A | 0.968 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITGB5 | TOR3A | 0.954 | 0.124 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCSK9 | ITGB5 | 0.443 | 0.148 | bioplex3_WMM WMM_only |
Related Complexes