hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07113.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMELESS | Protein timeless homolog (hTIM) | 5 | UniProt NCBI |
| MCMBP | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | 5 | UniProt NCBI |
| MCM2 | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | 5 | UniProt NCBI |
| MCM6 | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | 5 | UniProt NCBI |
| MCM7 | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | 5 | UniProt NCBI |
| MCM4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2792 | 5.12628525639e-06 | 0.5 | MCM2 MCM6 | MCM2-MCM4-MCM6-MCM7 complex |
| CORUM:1452 | 5.12628525639e-06 | 0.5 | MCM2 MCM6 | MCM2-MCM6-MCM7 complex |
| CORUM:387 | 5.12628525639e-06 | 0.5 | MCM2 MCM6 | MCM complex |
| GO:0042555 | 6.34131776058e-05 | 0.75 | MCM2 MCMBP MCM6 | MCM complex |
| CORUM:5611 | 0.000281714206611 | 0.5 | MCM2 MCM6 | Emerin complex 24 |
| GO:0006261 | 0.000415139510394 | 1.0 | MCM2 MCM6 TIMELESS MCMBP | DNA-templated DNA replication |
| REAC:R-HSA-176974 | 0.000676052383047 | 0.5 | MCM2 MCM6 | Unwinding of DNA |
| KEGG:03030 | 0.00157527945983 | 0.5 | MCM2 MCM6 | DNA replication |
| WP:WP466 | 0.002190823719 | 0.5 | MCM2 MCM6 | DNA replication |
| GO:0006260 | 0.00227782697336 | 1.0 | MCM2 MCM6 TIMELESS MCMBP | DNA replication |
| HPA:0031302 | 0.00299780253789 | 0.75 | MCM2 TIMELESS MCM6 | appendix; enterocytes[>=Medium] |
| GO:0090329 | 0.00350727150095 | 0.75 | MCM2 TIMELESS MCM6 | regulation of DNA-templated DNA replication |
| HPA:0401302 | 0.00363859717777 | 0.75 | MCM2 TIMELESS MCM6 | rectum; enterocytes[>=Medium] |
| REAC:R-HSA-69190 | 0.00507136546841 | 0.5 | MCM2 MCM6 | DNA strand elongation |
| WP:WP45 | 0.00511942554749 | 0.5 | MCM2 MCM6 | G1 to S cell cycle control |
| REAC:R-HSA-68962 | 0.00539805716719 | 0.5 | MCM2 MCM6 | Activation of the pre-replicative complex |
| HPA:0031301 | 0.00627490005786 | 0.75 | MCM2 TIMELESS MCM6 | appendix; enterocytes[>=Low] |
| REAC:R-HSA-176187 | 0.00643909852192 | 0.5 | MCM2 MCM6 | Activation of ATR in response to replication stress |
| HPA:0131301 | 0.00751334778666 | 0.75 | MCM2 TIMELESS MCM6 | colon; enterocytes[>=Low] |
| HPA:0401301 | 0.00783284002204 | 0.75 | MCM2 TIMELESS MCM6 | rectum; enterocytes[>=Low] |
| HPA:0151301 | 0.00878657325031 | 0.75 | MCM2 TIMELESS MCM6 | duodenum; enterocytes[>=Low] |
| HPA:0401331 | 0.00884494723476 | 0.75 | MCM2 TIMELESS MCM6 | rectum; mucosal lymphoid cells[>=Low] |
| HPA:0030433 | 0.0147119604908 | 0.5 | MCM2 MCM6 | appendix; germinal center cells[High] |
| WP:WP179 | 0.0168573248614 | 0.5 | MCM2 MCM6 | Cell cycle |
| HPA:0461412 | 0.017037547013 | 0.75 | MCM2 TIMELESS MCM6 | skin 1; cells in spinous layer[>=Medium] |
| REAC:R-HSA-68949 | 0.0246065982605 | 0.5 | MCM2 MCM6 | Orc1 removal from chromatin |
| CORUM:2791 | 0.0249718442456 | 0.25 | MCM6 | MCM4-MCM6-MCM7 complex |
| KEGG:04110 | 0.0280208578488 | 0.5 | MCM2 MCM6 | Cell cycle |
| HPA:0471392 | 0.0346964580744 | 0.75 | MCM2 TIMELESS MCM6 | skin 2; cells in basal layer[>=Medium] |
| HPA:0461411 | 0.0364546459466 | 0.75 | MCM2 TIMELESS MCM6 | skin 1; cells in spinous layer[>=Low] |
| REAC:R-HSA-69052 | 0.0407325822829 | 0.5 | MCM2 MCM6 | Switching of origins to a post-replicative state |
| HPA:0471471 | 0.0414271565288 | 0.75 | MCM2 TIMELESS MCM6 | skin 2; lymphocytes[>=Low] |
| CORUM:6261 | 0.049938562206 | 0.25 | MCM2 | Histone-2-Histone-4-ASF1-MCM2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MCM6 | MCM4 | 1.0 | 0.986 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM6 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| MCM2 | MCM4 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| MCM4 | MCM7 | 1.0 | 0.988 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM6 | MCM7 | 0.999 | 0.974 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM7 | 0.999 | 0.98 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| MCMBP | MCM6 | 0.998 | 0.304 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| MCMBP | MCM7 | 0.996 | 0.396 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction treiber_WMM |
| MCM2 | TIMELESS | 0.995 | 0.512 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| MCM6 | TIMELESS | 0.995 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| MCM4 | TIMELESS | 0.991 | 0.382 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MCM7 | TIMELESS | 0.988 | 0.464 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MCMBP | MCM2 | 0.987 | 0.207047619048 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM treiber_WMM WMM_only |
| MCMBP | MCM4 | 0.98 | 0.436 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
| MCMBP | TIMELESS | 0.024 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes