hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07118.1
Complex Portal: CPX-19659
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMED4 | Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) | 5 | UniProt NCBI |
| TMED3 | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | 5 | UniProt NCBI |
| GOLGB1 | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | 5 | UniProt NCBI |
| FGF3 | Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2) | 5 | UniProt NCBI |
| TMED10 | Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | 5 | UniProt NCBI |
| TMED2 | Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) | 5 | UniProt NCBI |
| TMED9 | Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) | 5 | UniProt NCBI |
| TMED1 | Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1) | 5 | UniProt NCBI |
| TMED5 | Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28) | 5 | UniProt NCBI |
| CTXN1 | Cortexin-1 | 2 | UniProt NCBI |
| CHST8 | Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) | 5 | UniProt NCBI |
| LIPG | Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005793 | 1.46757259141e-11 | 0.727272727273 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 GOLGB1 TMED5 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0007030 | 1.31801590286e-10 | 0.727272727273 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 GOLGB1 TMED5 | Golgi organization |
| GO:0030134 | 9.37734043607e-10 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | COPII-coated ER to Golgi transport vesicle |
| GO:0006888 | 3.00160473433e-08 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-948021 | 2.77553541085e-07 | 0.545454545455 | TMED9 TMED10 TMED3 CHST8 GOLGB1 TMED2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6807878 | 1.27700862839e-06 | 0.454545454545 | TMED3 TMED9 TMED10 TMED2 GOLGB1 | COPI-mediated anterograde transport |
| GO:0030135 | 2.74619917639e-06 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | coated vesicle |
| GO:0005794 | 3.69915796966e-06 | 0.909090909091 | TMED9 TMED4 TMED1 LIPG TMED3 TMED2 TMED10 GOLGB1 TMED5 CHST8 | Golgi apparatus |
| GO:0010256 | 4.57408494759e-06 | 0.727272727273 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 GOLGB1 TMED5 | endomembrane system organization |
| REAC:R-HSA-446203 | 5.51690839215e-06 | 0.545454545455 | TMED9 TMED10 TMED3 CHST8 GOLGB1 TMED2 | Asparagine N-linked glycosylation |
| REAC:R-HSA-199977 | 9.54466806941e-06 | 0.454545454545 | TMED3 TMED9 TMED10 TMED2 GOLGB1 | ER to Golgi Anterograde Transport |
| GO:0048193 | 1.05301297737e-05 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | Golgi vesicle transport |
| REAC:R-HSA-6811434 | 0.000126946395471 | 0.363636363636 | TMED3 TMED9 TMED2 TMED10 | COPI-dependent Golgi-to-ER retrograde traffic |
| GO:0035964 | 0.000316805542726 | 0.272727272727 | TMED10 TMED2 TMED9 | COPI-coated vesicle budding |
| GO:0048200 | 0.000316805542726 | 0.272727272727 | TMED10 TMED2 TMED9 | Golgi transport vesicle coating |
| GO:0048205 | 0.000316805542726 | 0.272727272727 | TMED10 TMED2 TMED9 | COPI coating of Golgi vesicle |
| REAC:R-HSA-8856688 | 0.00042969008262 | 0.363636363636 | TMED3 TMED9 TMED2 TMED10 | Golgi-to-ER retrograde transport |
| GO:0006886 | 0.000624290559965 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | intracellular protein transport |
| GO:0048194 | 0.00132894467527 | 0.272727272727 | TMED10 TMED2 TMED9 | Golgi vesicle budding |
| GO:0033116 | 0.00139431270595 | 0.363636363636 | TMED3 TMED9 TMED2 TMED10 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| HPA:0420053 | 0.00194474515825 | 0.636363636364 | TMED9 TMED4 TMED3 TMED2 TMED10 GOLGB1 TMED5 | salivary gland; glandular cells[High] |
| REAC:R-HSA-6811442 | 0.00234405547967 | 0.363636363636 | TMED3 TMED9 TMED2 TMED10 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| WP:WP5380 | 0.00455328541335 | 0.272727272727 | TMED10 TMED2 TMED9 | 5q35 copy number variation |
| GO:0005798 | 0.00732163293254 | 0.363636363636 | TMED3 TMED9 TMED2 TMED10 | Golgi-associated vesicle |
| GO:0000139 | 0.00883266310821 | 0.545454545455 | TMED9 TMED10 TMED3 CHST8 GOLGB1 TMED2 | Golgi membrane |
| REAC:R-HSA-199991 | 0.00895179919263 | 0.454545454545 | TMED3 TMED9 TMED10 TMED2 GOLGB1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0116257688566 | 0.454545454545 | TMED3 TMED9 TMED10 TMED2 GOLGB1 | Vesicle-mediated transport |
| GO:0015031 | 0.0145022498416 | 0.636363636364 | TMED9 TMED4 TMED1 TMED3 TMED2 TMED10 TMED5 | protein transport |
| GO:0030137 | 0.0179543561972 | 0.272727272727 | TMED3 TMED2 TMED10 | COPI-coated vesicle |
| HPA:0160053 | 0.0271372779516 | 0.545454545455 | TMED9 TMED4 TMED3 TMED2 TMED10 GOLGB1 | endometrium 1; glandular cells[High] |
| GO:0071702 | 0.0274343814199 | 0.727272727273 | TMED9 TMED4 TMED1 LIPG TMED3 TMED2 TMED10 TMED5 | organic substance transport |
| GO:0033036 | 0.0276141396626 | 0.818181818182 | TMED9 TMED4 TMED1 LIPG TMED3 TMED2 TMED10 GOLGB1 TMED5 | macromolecule localization |
| REAC:R-HSA-597592 | 0.0292756297165 | 0.545454545455 | TMED9 TMED10 TMED3 CHST8 GOLGB1 TMED2 | Post-translational protein modification |
| REAC:R-HSA-5694530 | 0.0463538386504 | 0.181818181818 | TMED10 TMED2 | Cargo concentration in the ER |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| TMED2 | TMED9 | 1.0 | 0.92 |
structurally_consistent (dimer)
|
| TMED2 | TMED1 | 1.0 | 0.676 |
mutually_exclusive (P49755)
structurally_consistent (dimer) |
| TMED4 | TMED2 | 1.0 | 0.922 | |
| TMED9 | TMED5 | 1.0 | 0.386 | |
| TMED2 | TMED5 | 1.0 | 0.654 |
mutually_exclusive (P49755)
|
| TMED3 | TMED2 | 1.0 | 0.356 |
mutually_exclusive (P49755)
|
| TMED2 | TMED10 | 1.0 | 0.858 |
mutually_exclusive (Q13445)
structurally_consistent (dimer) |
| TMED9 | TMED10 | 1.0 | 0.928 | |
| TMED10 | TMED1 | 1.0 | 0.508 |
mutually_exclusive (Q15363)
structurally_consistent (dimer) |
| TMED3 | TMED10 | 1.0 | 0.238 |
structurally_consistent (dimer)
|
| TMED9 | TMED1 | 1.0 | 0.656 |
mutually_exclusive (Q15363)
structurally_consistent (dimer) |
| TMED10 | TMED5 | 0.999 | 0.676 |
structurally_consistent (dimer)
|
| TMED4 | TMED5 | 0.999 | 0.554 | |
| LIPG | TMED5 | 0.999 | ||
| TMED3 | TMED9 | 0.999 | 0.212 |
structurally_consistent (dimer)
|
| TMED4 | TMED1 | 0.999 | 0.578 | |
| TMED3 | TMED1 | 0.998 | 0.208 | |
| TMED4 | TMED10 | 0.998 | 0.928 | |
| TMED4 | TMED9 | 0.997 | 0.734 | |
| TMED4 | TMED3 | 0.997 | 0.236 |
mutually_exclusive (Q9Y3B3)
structurally_consistent (dimer) |
| TMED1 | TMED5 | 0.996 | 0.272 |
mutually_exclusive (P49755)
|
| LIPG | TMED10 | 0.996 | ||
| TMED3 | TMED5 | 0.996 | 0.14 |
mutually_exclusive (P49755)
|
| CHST8 | TMED5 | 0.995 | ||
| LIPG | TMED2 | 0.995 | ||
| CTXN1 | TMED2 | 0.994 | ||
| LIPG | TMED9 | 0.994 | ||
| GOLGB1 | TMED2 | 0.994 | 0.132 | |
| GOLGB1 | TMED9 | 0.992 | 0.2 | |
| TMED2 | CHST8 | 0.992 | ||
| GOLGB1 | TMED10 | 0.992 | 0.16 | |
| TMED9 | CHST8 | 0.988 |
structurally_consistent (dimer)
|
|
| TMED4 | CHST8 | 0.985 | ||
| GOLGB1 | TMED5 | 0.981 | 0.072 | |
| LIPG | TMED4 | 0.98 | ||
| FGF3 | TMED1 | 0.977 | ||
| FGF3 | TMED2 | 0.977 | ||
| CHST8 | TMED10 | 0.973 | ||
| CHST8 | TMED1 | 0.972 |
mutually_exclusive (Q9BVK6)
|
|
| CTXN1 | TMED10 | 0.965 | ||
| FGF3 | TMED9 | 0.949 | ||
| CTXN1 | TMED9 | 0.949 | ||
| TMED3 | CHST8 | 0.943 | ||
| FGF3 | TMED4 | 0.93 | ||
| LIPG | TMED1 | 0.918 | ||
| GOLGB1 | TMED1 | 0.894 | 0.1 | |
| TMED4 | GOLGB1 | 0.89 | 0.178 | |
| FGF3 | TMED10 | 0.862 | ||
| CTXN1 | TMED3 | 0.857 | ||
| TMED3 | GOLGB1 | 0.844 | 0.138 | |
| CTXN1 | TMED4 | 0.759 | ||
| FGF3 | TMED5 | 0.619 | ||
| CTXN1 | TMED1 | 0.604 | ||
| CTXN1 | TMED5 | 0.32 | ||
| CTXN1 | GOLGB1 | 0.306 |
Related Complexes