hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07122.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHC2 | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | 5 | UniProt NCBI |
| CBX2 | Chromobox protein homolog 2 | 5 | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | 5 | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | 5 | UniProt NCBI |
| BMI1 | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | 5 | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | 5 | UniProt NCBI |
| PCGF2 | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | 5 | UniProt NCBI |
| SFMBT2 | Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) | 5 | UniProt NCBI |
| SCML1 | Sex comb on midleg-like protein 1 | 4 | UniProt NCBI |
| CBX7 | Chromobox protein homolog 7 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 7.74318099223e-22 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | Polycomb repressive complex |
| CORUM:116 | 5.23138082007e-16 | 0.6 | PHC3 CBX2 BMI1 PHC1 SCMH1 PHC2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:115 | 5.23138082007e-16 | 0.6 | PHC3 CBX2 BMI1 PHC1 SCMH1 PHC2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0035102 | 2.42849715929e-15 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | PRC1 complex |
| REAC:R-HSA-4655427 | 1.87365996784e-14 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation of DNA methylation proteins |
| GO:0031519 | 5.70026207713e-12 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | PcG protein complex |
| GO:0000152 | 8.09385300083e-12 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | nuclear ubiquitin ligase complex |
| REAC:R-HSA-3899300 | 1.02791170117e-11 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 2.2672857028e-11 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4551638 | 3.36081847456e-10 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 5.29136136461e-10 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-8939243 | 4.09612895943e-09 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| CORUM:5518 | 1.68385473419e-08 | 0.3 | PHC2 PHC1 BMI1 | BMI1-HPH1-HPH2 complex |
| GO:0045892 | 2.51075221634e-08 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of DNA-templated transcription |
| GO:1902679 | 2.81827530589e-08 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of RNA biosynthetic process |
| REAC:R-HSA-8943724 | 4.52218851815e-08 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Regulation of PTEN gene transcription |
| REAC:R-HSA-3108232 | 7.10457411178e-08 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMO E3 ligases SUMOylate target proteins |
| GO:0051253 | 7.53830275493e-08 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of RNA metabolic process |
| REAC:R-HSA-2990846 | 8.58028114953e-08 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | SUMOylation |
| GO:0045934 | 2.06820136471e-07 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of nucleobase-containing compound metabolic process |
| GO:0003682 | 3.22773530178e-07 | 0.8 | PHC3 SCML1 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 | chromatin binding |
| GO:0042393 | 5.98064921821e-07 | 0.7 | PHC3 SCML1 CBX2 PHC1 SCMH1 PHC2 SFMBT2 | histone binding |
| REAC:R-HSA-2559580 | 1.13184038557e-06 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-8953750 | 1.22580923685e-06 | 0.4 | PHC3 PCGF2 PHC1 BMI1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-6807070 | 3.66169587719e-06 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | PTEN Regulation |
| GO:0000151 | 4.77654391654e-06 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | ubiquitin ligase complex |
| GO:0010558 | 6.27004236457e-06 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of macromolecule biosynthetic process |
| GO:0031327 | 7.85174280004e-06 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of cellular biosynthetic process |
| GO:0051172 | 8.27251112535e-06 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of nitrogen compound metabolic process |
| GO:0009890 | 8.32650923975e-06 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of biosynthetic process |
| REAC:R-HSA-2559583 | 1.3480690197e-05 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Cellular Senescence |
| REAC:R-HSA-8878171 | 3.43347437563e-05 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Transcriptional regulation by RUNX1 |
| GO:0031324 | 4.81674661185e-05 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of cellular metabolic process |
| REAC:R-HSA-1257604 | 5.27600425105e-05 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | PIP3 activates AKT signaling |
| GO:0010605 | 5.81996362636e-05 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of macromolecule metabolic process |
| REAC:R-HSA-9006925 | 0.000106667191123 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Intracellular signaling by second messengers |
| GO:0009892 | 0.00012727804173 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of metabolic process |
| CORUM:5513 | 0.000184411585051 | 0.2 | BMI1 PHC1 | RING1-Polycomb repressive complex |
| CORUM:1462 | 0.000184411585051 | 0.2 | PHC2 BMI1 | hPRC1L complex |
| GO:0006355 | 0.000478593942439 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of DNA-templated transcription |
| GO:2001141 | 0.00050846345131 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.000769096906474 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | DNA-templated transcription |
| GO:0032774 | 0.000855932930644 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | RNA biosynthetic process |
| GO:0051252 | 0.00146550722958 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of RNA metabolic process |
| GO:0044877 | 0.00293647708351 | 0.8 | PHC3 SCML1 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 | protein-containing complex binding |
| GO:0034654 | 0.00300537391933 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | nucleobase-containing compound biosynthetic process |
| GO:0018130 | 0.00360676293504 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | heterocycle biosynthetic process |
| GO:0019438 | 0.00364529640625 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | aromatic compound biosynthetic process |
| GO:0019219 | 0.00365822298925 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of nucleobase-containing compound metabolic process |
| REAC:R-HSA-212436 | 0.00465548020126 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | Generic Transcription Pathway |
| GO:1901362 | 0.0048698369109 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | organic cyclic compound biosynthetic process |
| GO:1990234 | 0.00609373273501 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | transferase complex |
| REAC:R-HSA-73857 | 0.0087488365386 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | RNA Polymerase II Transcription |
| GO:0140535 | 0.00904965232253 | 0.7 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 CBX7 | intracellular protein-containing complex |
| REAC:R-HSA-597592 | 0.0133621598082 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | Post-translational protein modification |
| GO:0016070 | 0.0139641671754 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | RNA metabolic process |
| REAC:R-HSA-2262752 | 0.0144474363473 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0151311453833 | 0.5 | PHC2 PHC1 BMI1 CBX2 PHC3 | Cellular responses to stimuli |
| REAC:R-HSA-74160 | 0.0179061878456 | 0.6 | PHC3 CBX2 PCGF2 BMI1 PHC1 PHC2 | Gene expression (Transcription) |
| GO:0010468 | 0.0204731292091 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of gene expression |
| GO:0048523 | 0.0210913272216 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of cellular process |
| GO:0044271 | 0.0220501553308 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | cellular nitrogen compound biosynthetic process |
| GO:0010556 | 0.0279393069327 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of macromolecule biosynthetic process |
| GO:0031326 | 0.0348126464055 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of cellular biosynthetic process |
| GO:0009889 | 0.0369341229167 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | regulation of biosynthetic process |
| GO:0048519 | 0.0431720455778 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | negative regulation of biological process |
| GO:0090304 | 0.0476672618515 | 1.0 | PHC3 SCML1 CBX2 PCGF2 BMI1 PHC1 SCMH1 PHC2 SFMBT2 CBX7 | nucleic acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHC1 | PCGF2 | 1.0 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHC2 | PCGF2 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHC3 | PCGF2 | 1.0 | 0.24 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHC1 | SCMH1 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHC2 | PHC1 | 1.0 | 0.184 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PHC1 | BMI1 | 1.0 | 0.182628865979 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHC2 | BMI1 | 0.999 | 0.418 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PHC2 | PHC3 | 0.999 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PHC3 | PHC1 | 0.999 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CBX2 | PCGF2 | 0.999 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CBX2 | PHC1 | 0.999 | 0.13 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CBX7 | PHC1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBX7 | PCGF2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHC2 | CBX7 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CBX7 | BMI1 | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PCGF2 | BMI1 | 0.998 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHC3 | BMI1 | 0.998 | 0.374 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SCMH1 | PCGF2 | 0.997 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHC3 | CBX7 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PHC1 | SFMBT2 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CBX2 | BMI1 | 0.989 | 0.256 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SCML1 | PHC1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PHC2 | CBX2 | 0.972 | 0.218 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SCML1 | PCGF2 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SCMH1 | BMI1 | 0.965 | 0.162736842105 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PHC3 | SCMH1 | 0.886 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| PHC2 | SCMH1 | 0.886 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| CBX2 | SCMH1 | 0.861 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| PHC3 | CBX2 | 0.827 | 0.214 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CBX7 | CBX2 | 0.731 | bioplex_WMM bioplex3_WMM WMM_only | |
| CBX7 | SCMH1 | 0.58 | bioplex_WMM bioplex3_WMM WMM_only | |
| CBX7 | SFMBT2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCMH1 | SFMBT2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHC2 | SFMBT2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| SFMBT2 | PCGF2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| CBX2 | SFMBT2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHC3 | SFMBT2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | SFMBT2 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| SFMBT2 | BMI1 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | BMI1 | 0.265 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | PHC2 | 0.234 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | SCMH1 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | CBX7 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCML1 | CBX2 | 0.198 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SCML1 | PHC3 | 0.182 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes