hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07128.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPRL2 | GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | 5 | UniProt NCBI |
| NPRL3 | GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | 5 | UniProt NCBI |
| OGA | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | 5 | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | 5 | UniProt NCBI |
| DEPDC5 | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6215 | 2.80233355908e-09 | 0.6 | NPRL2 NPRL3 DEPDC5 | GATOR1 complex |
| REAC:R-HSA-9639288 | 1.24745525372e-07 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | Amino acids regulate mTORC1 |
| CORUM:6217 | 1.56850139259e-07 | 0.6 | NPRL2 NPRL3 DEPDC5 | GATOR complex |
| HP:0012004 | 2.63261482157e-07 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal cognitive seizure with deja vu/jamais vu |
| HP:0032680 | 2.63261482157e-07 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal cognitive seizure |
| HP:0012005 | 2.63261482157e-07 | 0.6 | NPRL2 NPRL3 DEPDC5 | Deja vu aura |
| HP:0008765 | 4.60660292877e-07 | 0.6 | NPRL2 NPRL3 DEPDC5 | Auditory hallucination |
| HP:0033346 | 1.10535767725e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Psychic epileptic aura |
| HP:0012002 | 1.10535767725e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Experiential epileptic aura |
| HP:0002427 | 2.17079240018e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Expressive aphasia |
| HP:0007206 | 4.78742429485e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Hemimegalencephaly |
| HP:0031951 | 4.78742429485e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Nocturnal seizures |
| HP:0032046 | 4.78742429485e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal cortical dysplasia |
| HP:0002367 | 5.98366572629e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | Visual hallucination |
| REAC:R-HSA-9711097 | 9.29860795994e-06 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | Cellular response to starvation |
| GO:1990130 | 9.61003071434e-06 | 0.6 | NPRL2 NPRL3 DEPDC5 | GATOR1 complex |
| HP:0033348 | 1.27380001354e-05 | 0.6 | NPRL2 NPRL3 DEPDC5 | Epileptic aura |
| GO:1904262 | 1.46952249556e-05 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | negative regulation of TORC1 signaling |
| GO:0034198 | 1.62015385296e-05 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | cellular response to amino acid starvation |
| HP:0011171 | 1.7479937387e-05 | 0.6 | NPRL2 NPRL3 DEPDC5 | Simple febrile seizure |
| HP:0002349 | 1.7479937387e-05 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal aware seizure |
| GO:1990928 | 1.95582475037e-05 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | response to amino acid starvation |
| GO:0032007 | 5.96974946777e-05 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | negative regulation of TOR signaling |
| HP:0032052 | 6.41370849429e-05 | 0.4 | NPRL3 DEPDC5 | Focal cortical dysplasia type IIa |
| HP:0032679 | 7.85415640073e-05 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal non-motor seizure |
| HP:0001355 | 0.000101951828436 | 0.6 | NPRL2 NPRL3 DEPDC5 | Megalencephaly |
| HP:0031284 | 0.000173652293474 | 0.6 | NPRL2 NPRL3 DEPDC5 | Flushing |
| WP:WP4657 | 0.000193319733332 | 0.6 | NPRL2 NPRL3 DEPDC5 | 22q11 2 copy number variation syndrome |
| GO:1903432 | 0.000265205672168 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | regulation of TORC1 signaling |
| HP:0002539 | 0.000272856062575 | 0.6 | NPRL2 NPRL3 DEPDC5 | Cortical dysplasia |
| GO:0035859 | 0.000274621184043 | 0.6 | NPRL2 NPRL3 DEPDC5 | Seh1-associated complex |
| GO:0038202 | 0.000319733015871 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | TORC1 signaling |
| CORUM:6753 | 0.00038189088864 | 0.4 | NPRL2 NPRL3 | SOG complex |
| HP:0010841 | 0.000471067856483 | 0.6 | NPRL2 NPRL3 DEPDC5 | Multifocal epileptiform discharges |
| KEGG:04150 | 0.000486709886236 | 0.6 | NPRL2 NPRL3 DEPDC5 | mTOR signaling pathway |
| HP:0032051 | 0.000641107533884 | 0.4 | NPRL3 DEPDC5 | Focal cortical dysplasia type II |
| GO:0009267 | 0.00103813210542 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | cellular response to starvation |
| GO:0032006 | 0.00122611762455 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | regulation of TOR signaling |
| HP:0002381 | 0.00124420731676 | 0.6 | NPRL2 NPRL3 DEPDC5 | Aphasia |
| GO:0042594 | 0.00178074577644 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | response to starvation |
| GO:0031929 | 0.00188884895508 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | TOR signaling |
| HP:0002384 | 0.00204495106592 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal impaired awareness seizure |
| HP:0011185 | 0.00244253615615 | 0.6 | NPRL2 NPRL3 DEPDC5 | EEG with focal epileptiform discharges |
| HP:0003401 | 0.00296757123606 | 0.6 | NPRL2 NPRL3 DEPDC5 | Paresthesia |
| HP:0032894 | 0.00321376516039 | 0.6 | NPRL2 NPRL3 DEPDC5 | Seizure precipitated by febrile infection |
| HP:0032892 | 0.00321376516039 | 0.6 | NPRL2 NPRL3 DEPDC5 | Infection-related seizure |
| HP:0002373 | 0.00321376516039 | 0.6 | NPRL2 NPRL3 DEPDC5 | Febrile seizure (within the age range of 3 months to 6 years) |
| GO:0031669 | 0.0035170104576 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | cellular response to nutrient levels |
| HP:0003829 | 0.00393572415664 | 0.6 | NPRL2 NPRL3 DEPDC5 | Typified by incomplete penetrance |
| GO:0031668 | 0.00437843642246 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | cellular response to extracellular stimulus |
| REAC:R-HSA-2262752 | 0.00463311209834 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | Cellular responses to stress |
| HP:0000738 | 0.00464946977244 | 0.6 | NPRL2 NPRL3 DEPDC5 | Hallucinations |
| REAC:R-HSA-8953897 | 0.00481362685522 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | Cellular responses to stimuli |
| HP:0012469 | 0.00486809738821 | 0.6 | NPRL2 NPRL3 DEPDC5 | Infantile spasms |
| HP:0000980 | 0.00520866341226 | 0.6 | NPRL2 NPRL3 DEPDC5 | Pallor |
| HP:0002521 | 0.0080439694067 | 0.6 | NPRL2 NPRL3 DEPDC5 | Hypsarrhythmia |
| GO:0071496 | 0.00911621649963 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | cellular response to external stimulus |
| HP:0033259 | 0.0105962255115 | 0.6 | NPRL2 NPRL3 DEPDC5 | Non-motor seizure |
| HP:0011097 | 0.0109723643764 | 0.6 | NPRL2 NPRL3 DEPDC5 | Epileptic spasm |
| GO:0031667 | 0.0121225590206 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | response to nutrient levels |
| HP:0002126 | 0.0121536331541 | 0.6 | NPRL2 NPRL3 DEPDC5 | Polymicrogyria |
| GO:0009991 | 0.0147584065712 | 0.8 | NPRL2 DEPDC5 NPRL3 BMT2 | response to extracellular stimulus |
| HP:0033747 | 0.019057059631 | 0.6 | NPRL2 NPRL3 DEPDC5 | Abnormal exteroceptive sensation |
| HP:0011146 | 0.0198915186532 | 0.6 | NPRL2 NPRL3 DEPDC5 | Dialeptic seizure |
| HP:0011198 | 0.0267599042538 | 0.6 | NPRL2 NPRL3 DEPDC5 | EEG with generalized epileptiform discharges |
| HP:0011182 | 0.043417085174 | 0.6 | NPRL2 NPRL3 DEPDC5 | Interictal epileptiform activity |
| HP:0025373 | 0.044850219801 | 0.6 | NPRL2 NPRL3 DEPDC5 | Interictal EEG abnormality |
| HP:0007359 | 0.0488237559993 | 0.6 | NPRL2 NPRL3 DEPDC5 | Focal-onset seizure |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NPRL2 | DEPDC5 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NPRL2 | NPRL3 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BMT2 | DEPDC5 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DEPDC5 | NPRL3 | 0.996 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | BMT2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| OGA | BMT2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BMT2 | NPRL3 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| OGA | DEPDC5 | 0.345 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | OGA | 0.254 | 0.05 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGA | NPRL3 | 0.063 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes