hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07130.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | 5 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt NCBI |
| PAXX | Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 0.0249718442457 | 0.5 | WRN | XRCC6-XRCC5-WRN complex |
| CORUM:1217 | 0.0499419797295 | 0.5 | WRN | WRN-TRF2 complex |
| CORUM:5235 | 0.0499419797295 | 0.5 | WRN | WRN-Ku70-Ku80-PARP1 complex |
| CORUM:7282 | 0.0499419797295 | 0.5 | WRN | FEN1-WRN complex |
| HP:0012060 | 0.0499436884913 | 0.5 | WRN | Acral lentiginous melanoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XRCC6 | XRCC5 | 1.0 | 0.96 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| WRN | XRCC6 | 0.999 | 0.32 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM |
| XRCC6 | PAXX | 0.997 | 0.064 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| XRCC5 | PAXX | 0.991 | 0.13 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| WRN | PAXX | 0.981 | 0.068 | hein_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| WRN | XRCC5 | 0.96 | 0.48 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM |
Related Complexes