hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07143.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDC4 | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | 5 | UniProt NCBI |
| PNRC1 | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | 4 | UniProt NCBI |
| PRAG1 | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | 5 | UniProt NCBI |
| DCP1A | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | 5 | UniProt NCBI |
| DCP2 | m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) | 5 | UniProt NCBI |
| DCP1B | mRNA-decapping enzyme 1B (EC 3.6.1.62) | 5 | UniProt NCBI |
| DDX6 | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | 5 | UniProt NCBI |
| EDC3 | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:559 | 9.2015673155e-16 | 0.625 | EDC3 DDX6 EDC4 DCP2 DCP1A | Decapping complex |
| REAC:R-HSA-430039 | 2.20287996704e-15 | 0.75 | DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | mRNA decay by 5' to 3' exoribonuclease |
| REAC:R-HSA-429914 | 1.26995447193e-11 | 0.75 | DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | Deadenylation-dependent mRNA decay |
| KEGG:03018 | 1.731442743e-11 | 0.75 | DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | RNA degradation |
| GO:0000932 | 2.80203562355e-11 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | P-body |
| GO:0110156 | 6.48076439894e-10 | 0.625 | EDC3 DCP1B EDC4 DCP2 DCP1A | methylguanosine-cap decapping |
| GO:0110154 | 2.198402683e-09 | 0.625 | EDC3 DCP1B EDC4 DCP2 DCP1A | RNA decapping |
| GO:0031087 | 9.20740386965e-09 | 0.5 | EDC3 DCP1B EDC4 DCP1A | deadenylation-independent decapping of nuclear-transcribed mRNA |
| GO:0031086 | 2.76161616937e-08 | 0.5 | EDC3 DCP1B EDC4 DCP1A | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| GO:0036464 | 4.0843531464e-08 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 7.14548677899e-08 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | ribonucleoprotein granule |
| GO:0000956 | 2.44641409782e-07 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | nuclear-transcribed mRNA catabolic process |
| GO:0006402 | 9.12589716273e-06 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | mRNA catabolic process |
| CORUM:1296 | 2.39226645298e-05 | 0.25 | DCP1A DCP2 | DCP1A-DCP2 Decapping complex |
| GO:0006401 | 3.05919474446e-05 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | RNA catabolic process |
| REAC:R-HSA-8953854 | 5.65270307937e-05 | 0.75 | DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | Metabolism of RNA |
| GO:0010629 | 0.000317580851345 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | negative regulation of gene expression |
| GO:0000290 | 0.00045145282213 | 0.375 | DCP1B DCP1A DCP2 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| GO:0034655 | 0.000472346511415 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | nucleobase-containing compound catabolic process |
| GO:0046700 | 0.000714738930825 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | heterocycle catabolic process |
| GO:0044270 | 0.000725010313136 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.000778224746726 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | aromatic compound catabolic process |
| GO:1901361 | 0.000970795950643 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | organic cyclic compound catabolic process |
| GO:0099080 | 0.00099796899113 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | supramolecular complex |
| GO:0016071 | 0.00379022160939 | 0.75 | PNRC1 DCP1B EDC4 DCP2 EDC3 DCP1A | mRNA metabolic process |
| REAC:R-HSA-450513 | 0.00666866305696 | 0.25 | DCP1A DCP2 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| REAC:R-HSA-450385 | 0.00755574884395 | 0.25 | DCP1A DCP2 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| GO:0010558 | 0.042949026104 | 0.875 | PNRC1 DCP1B EDC4 DDX6 DCP2 EDC3 DCP1A | negative regulation of macromolecule biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DDX6 | DCP1B | 1.0 | 0.138 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1B | EDC3 | 1.0 | 0.058 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| EDC3 | EDC4 | 1.0 | 0.338 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| DDX6 | DCP1A | 1.0 | 0.208 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1A | EDC3 | 1.0 | 0.502 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| EDC4 | DCP2 | 0.999 | 0.282 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 treiber_WMM |
| DCP1A | DCP2 | 0.999 | 0.242 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| DCP1B | DCP2 | 0.999 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| DCP1A | EDC4 | 0.999 | 0.238 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM |
| DDX6 | EDC3 | 0.999 | 0.284 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| EDC3 | DCP2 | 0.999 | 0.436 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| DDX6 | EDC4 | 0.998 | 0.32 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PNRC1 | DCP1A | 0.997 | hein_WMM youn () bioplex_WMM bioplex3_WMM hein () | |
| DDX6 | DCP2 | 0.994 | 0.146 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM treiber_WMM |
| DDX6 | PNRC1 | 0.991 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| DCP1A | DCP1B | 0.991 | 0.04 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| PNRC1 | EDC4 | 0.988 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| PRAG1 | EDC3 | 0.981 | 0.07 | hein_WMM bioplex3_WMM WMM_only |
| PNRC1 | EDC3 | 0.975 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRAG1 | DCP2 | 0.964 | 0.074 | hein_WMM bioplex3_WMM WMM_only |
| PRAG1 | DCP1A | 0.954 | 0.072 | hein_WMM bioplex3_WMM WMM_only |
| DDX6 | PRAG1 | 0.947 | 0.180366197183 | hein_WMM bioplex3_WMM WMM_only |
| PNRC1 | DCP2 | 0.938 | hein_WMM youn_WMM WMM_only | |
| PRAG1 | EDC4 | 0.918 | 0.11 | hein_WMM bioplex3_WMM WMM_only |
| DCP1B | EDC4 | 0.897 | 0.094 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| PNRC1 | DCP1B | 0.375 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRAG1 | PNRC1 | 0.248 | hein_WMM WMM_only | |
| PRAG1 | DCP1B | 0.079 | 0.122 | bioplex3_WMM WMM_only |
Related Complexes