hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07150.1
Complex Portal: CPX-21057
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NME3 | Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3) | 5 | UniProt NCBI |
| NDUFA4 | Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit) | 5 | UniProt NCBI |
| GGT7 | Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] | 5 | UniProt NCBI |
| NME2 | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | 5 | UniProt NCBI |
| ALDH3B2 | Aldehyde dehydrogenase family 3 member B2 (EC 1.2.1.3) (Aldehyde dehydrogenase 8) | 5 | UniProt NCBI |
| NFXL1 | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | 4 | UniProt NCBI |
| NME4 | Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) | 5 | UniProt NCBI |
| NME1 | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-499943 | 2.29983491089e-05 | 0.428571428571 | NME2 NME3 NME4 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00240 | 4.94026671671e-05 | 0.428571428571 | NME2 NME3 NME4 | Pyrimidine metabolism |
| KEGG:01100 | 0.000163213797031 | 0.857142857143 | NME2 ALDH3B2 NME3 NME4 NDUFA4 GGT7 | Metabolic pathways |
| KEGG:00983 | 0.000166028549175 | 0.428571428571 | NME2 NME3 NME4 | Drug metabolism - other enzymes |
| KEGG:01232 | 0.000189600065474 | 0.428571428571 | NME2 NME3 NME4 | Nucleotide metabolism |
| KEGG:00230 | 0.00052377688541 | 0.428571428571 | NME2 NME3 NME4 | Purine metabolism |
| GO:0004550 | 0.000554182028596 | 0.428571428571 | NME2 NME3 NME4 | nucleoside diphosphate kinase activity |
| REAC:R-HSA-15869 | 0.000939437311818 | 0.428571428571 | NME2 NME3 NME4 | Metabolism of nucleotides |
| KEGG:01240 | 0.00134023979054 | 0.428571428571 | NME2 NME3 NME4 | Biosynthesis of cofactors |
| REAC:R-HSA-1430728 | 0.00383440417299 | 0.857142857143 | NME2 ALDH3B2 NME3 NME4 NDUFA4 GGT7 | Metabolism |
| GO:0016776 | 0.00979189312029 | 0.428571428571 | NME2 NME3 NME4 | phosphotransferase activity, phosphate group as acceptor |
| GO:0019205 | 0.0200035679209 | 0.428571428571 | NME2 NME3 NME4 | nucleobase-containing compound kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NME1 | NME3 | 0.999 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| NME4 | NME3 | 0.998 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NME2 | NME3 | 0.997 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| NME2 | NME1 | 0.996 | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| GGT7 | NME3 | 0.993 | 0.054 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| NME1 | NME4 | 0.982 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GGT7 | NFXL1 | 0.97 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM | |
| NDUFA4 | NME3 | 0.958 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| NME3 | NFXL1 | 0.953 | 0.034 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| NME2 | NME4 | 0.914 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NDUFA4 | GGT7 | 0.353 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| NME4 | GGT7 | 0.182 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| NME4 | NFXL1 | 0.106 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| NDUFA4 | NFXL1 | 0.052 | 0.03 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| NDUFA4 | NME1 | 0.05 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| NDUFA4 | NME2 | 0.035 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| NDUFA4 | NME4 | 0.029 | 0.048 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NME2 | NFXL1 | 0.028 | 0.086 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| NME1 | NFXL1 | 0.017 | 0.162 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| NME2 | GGT7 | 0.011 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| NME1 | GGT7 | 0.004 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Related Complexes