hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07162.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOP2B | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | 5 | UniProt NCBI |
| NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | 5 | UniProt NCBI |
| H2AB1 | Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd) | 5 | UniProt NCBI |
| SENP3 | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | 5 | UniProt NCBI |
| PELP1 | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | 5 | UniProt NCBI |
| WDR18 | WD repeat-containing protein 18 | 5 | UniProt NCBI |
| SUV39H1 | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) | 5 | UniProt NCBI |
| LAS1L | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | 5 | UniProt NCBI |
| NAP1L1 | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6855 | 1.10483220475e-14 | 0.555555555556 | PELP1 LAS1L NOL9 WDR18 SENP3 | LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex |
| CORUM:6854 | 2.69032781214e-11 | 0.444444444444 | PELP1 LAS1L SENP3 WDR18 | 5FMC (Friends of Methylated Chtop) complex |
| REAC:R-HSA-6791226 | 7.69079973776e-06 | 0.555555555556 | PELP1 LAS1L NOL9 WDR18 SENP3 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 1.00848050737e-05 | 0.555555555556 | PELP1 LAS1L NOL9 WDR18 SENP3 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 1.30379529757e-05 | 0.555555555556 | PELP1 LAS1L NOL9 WDR18 SENP3 | rRNA processing |
| CORUM:5386 | 3.38382609301e-05 | 0.333333333333 | PELP1 SENP3 LAS1L | MLL1-WDR5 complex |
| CORUM:6857 | 8.20609246787e-05 | 0.222222222222 | PELP1 WDR18 | PELP1-TEX10-WDR18 complex |
| REAC:R-HSA-8953854 | 0.00564646741329 | 0.555555555556 | PELP1 LAS1L NOL9 WDR18 SENP3 | Metabolism of RNA |
| GO:0071339 | 0.0359812030822 | 0.333333333333 | PELP1 SENP3 LAS1L | MLL1 complex |
| GO:0044665 | 0.0396911574974 | 0.333333333333 | PELP1 SENP3 LAS1L | MLL1/2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SENP3 | WDR18 | 1.0 | 0.238 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| NOL9 | PELP1 | 1.0 | 0.87 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| NOL9 | WDR18 | 1.0 | 0.94 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| WDR18 | PELP1 | 1.0 | 0.97 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| NOL9 | LAS1L | 1.0 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| SENP3 | PELP1 | 1.0 | 0.388 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| WDR18 | LAS1L | 1.0 | 0.86 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| SENP3 | NOL9 | 1.0 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| LAS1L | PELP1 | 0.999 | 0.914 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction treiber_WMM |
| SENP3 | LAS1L | 0.999 | 0.586 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| H2AB1 | NOL9 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| H2AB1 | LAS1L | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SUV39H1 | SENP3 | 0.991 | 0.242 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SENP3 | TOP2B | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| H2AB1 | WDR18 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NOL9 | NAP1L1 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| H2AB1 | SENP3 | 0.969 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SENP3 | NAP1L1 | 0.969 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| SUV39H1 | TOP2B | 0.968 | hein_WMM bioplex3_WMM WMM_only | |
| LAS1L | TOP2B | 0.966 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| LAS1L | NAP1L1 | 0.943 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM | |
| TOP2B | PELP1 | 0.934 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| SUV39H1 | LAS1L | 0.893 | 0.208 | hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM |
| H2AB1 | PELP1 | 0.732 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NAP1L1 | PELP1 | 0.472 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| SUV39H1 | WDR18 | 0.453 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WDR18 | NAP1L1 | 0.317 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NOL9 | TOP2B | 0.173 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| SUV39H1 | PELP1 | 0.152 | 0.308 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WDR18 | TOP2B | 0.15 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SUV39H1 | NOL9 | 0.075 | 0.078 | bioplex3_HEK293 bioplex () bioplex3_WMM |
| H2AB1 | NAP1L1 | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NAP1L1 | TOP2B | 0.009 | bioplex3_WMM gupta_WMM WMM_only boldt_WMM | |
| SUV39H1 | NAP1L1 | 0.006 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes