hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07185.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FZD1 | Frizzled-1 (Fz-1) (hFz1) (FzE1) | 5 | UniProt NCBI |
| SCN8A | Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) | 5 | UniProt NCBI |
| FZD5 | Frizzled-5 (Fz-5) (hFz5) (FzE5) | 5 | UniProt NCBI |
| SCN7A | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | 5 | UniProt NCBI |
| SCN4A | Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) | 5 | UniProt NCBI |
| FZD8 | Frizzled-8 (Fz-8) (hFz8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-445095 | 1.24783008572e-05 | 0.5 | SCN8A SCN4A SCN7A | Interaction between L1 and Ankyrins |
| REAC:R-HSA-5576892 | 1.42587173715e-05 | 0.5 | SCN8A SCN4A SCN7A | Phase 0 - rapid depolarisation |
| WP:WP4150 | 1.64258598412e-05 | 0.5 | FZD5 FZD1 FZD8 | Wnt signaling in kidney disease |
| KEGG:05217 | 5.17924220524e-05 | 0.5 | FZD5 FZD1 FZD8 | Basal cell carcinoma |
| WP:WP3680 | 8.88924665549e-05 | 0.5 | FZD5 FZD1 FZD8 | Physico chemical features and toxicity associated pathways |
| WP:WP4336 | 0.000176844341332 | 0.5 | FZD5 FZD1 FZD8 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:04916 | 0.000180606252479 | 0.5 | FZD5 FZD1 FZD8 | Melanogenesis |
| WP:WP4258 | 0.000250309382919 | 0.5 | FZD5 FZD1 FZD8 | lncRNA in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-4608870 | 0.00027807877525 | 0.5 | FZD5 FZD1 FZD8 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-373080 | 0.00035066958474 | 0.5 | FZD5 FZD1 FZD8 | Class B/2 (Secretin family receptors) |
| WP:WP399 | 0.000364552713376 | 0.5 | FZD5 FZD1 FZD8 | Wnt signaling pathway and pluripotency |
| WP:WP3931 | 0.000439359505343 | 0.5 | FZD5 FZD1 FZD8 | Embryonic stem cell pluripotency pathways |
| WP:WP428 | 0.000452739259316 | 0.5 | FZD5 FZD1 FZD8 | Wnt signaling |
| WP:WP4787 | 0.000466386489926 | 0.5 | FZD5 FZD1 FZD8 | Osteoblast differentiation and related diseases |
| KEGG:04550 | 0.000548884136987 | 0.5 | FZD5 FZD1 FZD8 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04934 | 0.000620541886073 | 0.5 | FZD5 FZD1 FZD8 | Cushing syndrome |
| KEGG:05224 | 0.000650854752753 | 0.5 | FZD5 FZD1 FZD8 | Breast cancer |
| REAC:R-HSA-5576891 | 0.000689296551176 | 0.5 | SCN8A SCN4A SCN7A | Cardiac conduction |
| GO:0008331 | 0.000698569295426 | 0.5 | SCN8A SCN4A SCN7A | high voltage-gated calcium channel activity |
| KEGG:05226 | 0.000714389632372 | 0.5 | FZD5 FZD1 FZD8 | Gastric cancer |
| REAC:R-HSA-5340588 | 0.000722165722116 | 0.333333333333 | FZD5 FZD8 | Signaling by RNF43 mutants |
| REAC:R-HSA-4086400 | 0.00084703415394 | 0.5 | FZD5 FZD1 FZD8 | PCP/CE pathway |
| GO:0005248 | 0.000873077093697 | 0.5 | SCN8A SCN4A SCN7A | voltage-gated sodium channel activity |
| GO:0042813 | 0.000873077093697 | 0.5 | FZD5 FZD1 FZD8 | Wnt receptor activity |
| KEGG:04390 | 0.000989019592829 | 0.5 | FZD5 FZD1 FZD8 | Hippo signaling pathway |
| WP:WP4239 | 0.00101296969036 | 0.5 | FZD5 FZD1 FZD8 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04150 | 0.00103019356944 | 0.5 | FZD5 FZD1 FZD8 | mTOR signaling pathway |
| WP:WP4262 | 0.00103618541451 | 0.5 | FZD5 FZD1 FZD8 | Breast cancer pathway |
| KEGG:04310 | 0.0010724857814 | 0.5 | FZD5 FZD1 FZD8 | Wnt signaling pathway |
| REAC:R-HSA-373760 | 0.00119511538043 | 0.5 | SCN8A SCN4A SCN7A | L1CAM interactions |
| WP:WP3664 | 0.00120604069052 | 0.333333333333 | FZD8 FZD1 | Regulation of Wnt B catenin signaling by small molecule compounds |
| KEGG:05225 | 0.00127702731713 | 0.5 | FZD5 FZD1 FZD8 | Hepatocellular carcinoma |
| KEGG:05205 | 0.00191301809451 | 0.5 | FZD5 FZD1 FZD8 | Proteoglycans in cancer |
| REAC:R-HSA-3858494 | 0.00283909643482 | 0.5 | FZD5 FZD1 FZD8 | Beta-catenin independent WNT signaling |
| GO:0017147 | 0.00295184433846 | 0.5 | FZD5 FZD1 FZD8 | Wnt-protein binding |
| REAC:R-HSA-4641263 | 0.0035019037522 | 0.333333333333 | FZD5 FZD8 | Regulation of FZD by ubiquitination |
| REAC:R-HSA-397014 | 0.00380890170895 | 0.5 | SCN8A SCN4A SCN7A | Muscle contraction |
| GO:1902656 | 0.00387837112504 | 0.5 | SCN8A SCN4A SCN7A | calcium ion import into cytosol |
| GO:0098703 | 0.00387837112504 | 0.5 | SCN8A SCN4A SCN7A | calcium ion import across plasma membrane |
| WP:WP5124 | 0.00539895087355 | 0.5 | FZD5 FZD1 FZD8 | Alzheimer 39 s disease |
| WP:WP2059 | 0.00539895087355 | 0.5 | FZD5 FZD1 FZD8 | Alzheimer 39 s disease and miRNA effects |
| GO:0005272 | 0.00560226816097 | 0.5 | SCN8A SCN4A SCN7A | sodium channel activity |
| WP:WP5420 | 0.00776281964385 | 0.5 | SCN8A SCN4A SCN7A | ADHD and autism ASD linked metabolic pathways and SNP |
| KEGG:05165 | 0.00797489844932 | 0.5 | FZD5 FZD1 FZD8 | Human papillomavirus infection |
| GO:0005245 | 0.00860399003151 | 0.5 | SCN8A SCN4A SCN7A | voltage-gated calcium channel activity |
| REAC:R-HSA-201681 | 0.00997722991686 | 0.5 | FZD5 FZD1 FZD8 | TCF dependent signaling in response to WNT |
| GO:0005891 | 0.0104402436969 | 0.5 | SCN8A SCN4A SCN7A | voltage-gated calcium channel complex |
| REAC:R-HSA-4641262 | 0.0119428487471 | 0.333333333333 | FZD5 FZD1 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| KEGG:05010 | 0.0122631731838 | 0.5 | FZD5 FZD1 FZD8 | Alzheimer disease |
| REAC:R-HSA-500792 | 0.0134812218215 | 0.5 | FZD5 FZD1 FZD8 | GPCR ligand binding |
| REAC:R-HSA-4791275 | 0.0135559590666 | 0.333333333333 | FZD5 FZD8 | Signaling by WNT in cancer |
| KEGG:05022 | 0.0219191039446 | 0.5 | FZD5 FZD1 FZD8 | Pathways of neurodegeneration - multiple diseases |
| WP:WP5087 | 0.0221664611486 | 0.5 | FZD5 FZD1 FZD8 | Pleural mesothelioma |
| GO:0070509 | 0.0271028431288 | 0.5 | SCN8A SCN4A SCN7A | calcium ion import |
| KEGG:05200 | 0.0272817161758 | 0.5 | FZD5 FZD1 FZD8 | Pathways in cancer |
| REAC:R-HSA-195721 | 0.0291878756931 | 0.5 | FZD5 FZD1 FZD8 | Signaling by WNT |
| GO:0034704 | 0.0397388592171 | 0.5 | SCN8A SCN4A SCN7A | calcium channel complex |
| GO:0035567 | 0.0473097913612 | 0.5 | FZD5 FZD1 FZD8 | non-canonical Wnt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SCN8A | SCN4A | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD5 | SCN4A | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SCN7A | SCN4A | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD1 | SCN4A | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD8 | SCN4A | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD5 | SCN8A | 0.415 | bioplex3_WMM WMM_only | |
| SCN8A | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| FZD5 | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| FZD1 | SCN8A | 0.415 | bioplex3_WMM WMM_only | |
| FZD1 | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| FZD5 | FZD1 | 0.415 | bioplex3_WMM WMM_only | |
| FZD8 | SCN7A | 0.278 | bioplex3_WMM WMM_only | |
| FZD8 | SCN8A | 0.278 | bioplex3_WMM WMM_only | |
| FZD8 | FZD1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| FZD5 | FZD8 | 0.079 | bioplex3_WMM WMM_only |
Related Complexes