hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07203.1

Complex Portal: CPX-14077

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
H2BC26	Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1)	5	UniProt NCBI
CDYL	Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-)	5	UniProt NCBI
ARID5B	AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)	5	UniProt NCBI
RBP1	Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I)	5	UniProt NCBI
MIER1	Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)	5	UniProt NCBI
BAHD1	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	5	UniProt NCBI
MIER3	Mesoderm induction early response protein 3 (Mi-er3)	5	UniProt NCBI
H2BC13	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	5	UniProt NCBI
H2BC1	Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-171306	0.000373779293679	0.333333333333	H2BC26 H2BC1 H2BC13	Packaging Of Telomere Ends
HPA:0570773	0.000451046488333	0.444444444444	MIER1 H2BC13 H2BC26 CDYL	testis; peritubular cells[High]
REAC:R-HSA-73927	0.00046645184962	0.333333333333	H2BC26 H2BC1 H2BC13	Depurination
REAC:R-HSA-110330	0.00046645184962	0.333333333333	H2BC26 H2BC1 H2BC13	Recognition and association of DNA glycosylase with site containing an affected purine
REAC:R-HSA-110331	0.00046645184962	0.333333333333	H2BC26 H2BC1 H2BC13	Cleavage of the damaged purine
REAC:R-HSA-73928	0.00061212143341	0.333333333333	H2BC26 H2BC1 H2BC13	Depyrimidination
REAC:R-HSA-110328	0.00061212143341	0.333333333333	H2BC26 H2BC1 H2BC13	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-110329	0.00061212143341	0.333333333333	H2BC26 H2BC1 H2BC13	Cleavage of the damaged pyrimidine
REAC:R-HSA-73929	0.000652728146316	0.333333333333	H2BC26 H2BC1 H2BC13	Base-Excision Repair, AP Site Formation
REAC:R-HSA-73728	0.000785180918545	0.333333333333	H2BC26 H2BC1 H2BC13	RNA Polymerase I Promoter Opening
REAC:R-HSA-5334118	0.000832996184822	0.333333333333	H2BC26 H2BC1 H2BC13	DNA methylation
REAC:R-HSA-5625886	0.000934338987799	0.333333333333	H2BC26 H2BC1 H2BC13	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
REAC:R-HSA-9670095	0.000987938284138	0.333333333333	H2BC26 H2BC1 H2BC13	Inhibition of DNA recombination at telomere
REAC:R-HSA-427359	0.00104353727432	0.333333333333	H2BC26 H2BC1 H2BC13	SIRT1 negatively regulates rRNA expression
REAC:R-HSA-68616	0.00110117172447	0.333333333333	H2BC26 H2BC1 H2BC13	Assembly of the ORC complex at the origin of replication
REAC:R-HSA-2299718	0.00128664481505	0.333333333333	H2BC26 H2BC1 H2BC13	Condensation of Prophase Chromosomes
REAC:R-HSA-606279	0.00135277785859	0.333333333333	H2BC26 H2BC1 H2BC13	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-774815	0.00135277785859	0.333333333333	H2BC26 H2BC1 H2BC13	Nucleosome assembly
REAC:R-HSA-212300	0.00135277785859	0.333333333333	H2BC26 H2BC1 H2BC13	PRC2 methylates histones and DNA
REAC:R-HSA-9710421	0.00135277785859	0.333333333333	H2BC26 H2BC1 H2BC13	Defective pyroptosis
REAC:R-HSA-5693571	0.00135277785859	0.333333333333	H2BC26 H2BC1 H2BC13	Nonhomologous End-Joining (NHEJ)
REAC:R-HSA-1221632	0.00142112451214	0.333333333333	H2BC26 H2BC1 H2BC13	Meiotic synapsis
REAC:R-HSA-427389	0.00156460058052	0.333333333333	H2BC26 H2BC1 H2BC13	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
KEGG:05322	0.00161357227069	0.333333333333	H2BC26 H2BC1 H2BC13	Systemic lupus erythematosus
REAC:R-HSA-2559586	0.00179730264162	0.333333333333	H2BC26 H2BC1 H2BC13	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-9616222	0.00214169846164	0.333333333333	H2BC26 H2BC1 H2BC13	Transcriptional regulation of granulopoiesis
REAC:R-HSA-5693565	0.00214169846164	0.333333333333	H2BC26 H2BC1 H2BC13	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-912446	0.00223412593886	0.333333333333	H2BC26 H2BC1 H2BC13	Meiotic recombination
REAC:R-HSA-5693606	0.00223412593886	0.333333333333	H2BC26 H2BC1 H2BC13	DNA Double Strand Break Response
REAC:R-HSA-4839726	0.00233298849516	0.444444444444	H2BC13 H2BC26 H2BC1 ARID5B	Chromatin organization
REAC:R-HSA-3247509	0.00233298849516	0.444444444444	H2BC13 H2BC26 H2BC1 ARID5B	Chromatin modifying enzymes
REAC:R-HSA-1912408	0.00263020123437	0.333333333333	H2BC26 H2BC1 H2BC13	Pre-NOTCH Transcription and Translation
REAC:R-HSA-73884	0.00263020123437	0.333333333333	H2BC26 H2BC1 H2BC13	Base Excision Repair
REAC:R-HSA-201722	0.00273598606	0.333333333333	H2BC26 H2BC1 H2BC13	Formation of the beta-catenin:TCF transactivating complex
REAC:R-HSA-5250924	0.00284454699146	0.333333333333	H2BC26 H2BC1 H2BC13	B-WICH complex positively regulates rRNA expression
REAC:R-HSA-73772	0.00295591880297	0.333333333333	H2BC26 H2BC1 H2BC13	RNA Polymerase I Promoter Escape
REAC:R-HSA-8936459	0.00307013622401	0.333333333333	H2BC26 H2BC1 H2BC13	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
REAC:R-HSA-3214815	0.00307013622401	0.333333333333	H2BC26 H2BC1 H2BC13	HDACs deacetylate histones
REAC:R-HSA-5625740	0.00318723393935	0.333333333333	H2BC26 H2BC1 H2BC13	RHO GTPases activate PKNs
REAC:R-HSA-69473	0.00395224313584	0.333333333333	H2BC26 H2BC1 H2BC13	G2/M DNA damage checkpoint
KEGG:04613	0.00421630879124	0.333333333333	H2BC26 H2BC1 H2BC13	Neutrophil extracellular trap formation
KEGG:05034	0.00421630879124	0.333333333333	H2BC26 H2BC1 H2BC13	Alcoholism
REAC:R-HSA-5693607	0.00437642752576	0.333333333333	H2BC26 H2BC1 H2BC13	Processing of DNA double-strand break ends
REAC:R-HSA-5578749	0.00452422603622	0.333333333333	H2BC26 H2BC1 H2BC13	Transcriptional regulation by small RNAs
REAC:R-HSA-9645723	0.00452422603622	0.333333333333	H2BC26 H2BC1 H2BC13	Diseases of programmed cell death
REAC:R-HSA-1912422	0.00467528343252	0.333333333333	H2BC26 H2BC1 H2BC13	Pre-NOTCH Expression and Processing
REAC:R-HSA-5250913	0.00482963386549	0.333333333333	H2BC26 H2BC1 H2BC13	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-427413	0.0049873114417	0.333333333333	H2BC26 H2BC1 H2BC13	NoRC negatively regulates rRNA expression
REAC:R-HSA-977225	0.00514835022343	0.333333333333	H2BC26 H2BC1 H2BC13	Amyloid fiber formation
REAC:R-HSA-5250941	0.00548064743149	0.333333333333	H2BC26 H2BC1 H2BC13	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-2559582	0.00548064743149	0.333333333333	H2BC26 H2BC1 H2BC13	Senescence-Associated Secretory Phenotype (SASP)
REAC:R-HSA-73854	0.00565197376137	0.333333333333	H2BC26 H2BC1 H2BC13	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.00582679710393	0.333333333333	H2BC26 H2BC1 H2BC13	RNA Polymerase I Transcription
REAC:R-HSA-1500620	0.00582679710393	0.333333333333	H2BC26 H2BC1 H2BC13	Meiosis
REAC:R-HSA-9610379	0.00582679710393	0.333333333333	H2BC26 H2BC1 H2BC13	HCMV Late Events
REAC:R-HSA-157579	0.00600515130063	0.333333333333	H2BC26 H2BC1 H2BC13	Telomere Maintenance
REAC:R-HSA-5619507	0.00715131398855	0.333333333333	H2BC26 H2BC1 H2BC13	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	0.00715131398855	0.333333333333	H2BC26 H2BC1 H2BC13	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-2559580	0.00735532802602	0.333333333333	H2BC26 H2BC1 H2BC13	Oxidative Stress Induced Senescence
KEGG:05203	0.00814127516655	0.333333333333	H2BC26 H2BC1 H2BC13	Viral carcinogenesis
REAC:R-HSA-1474165	0.00843306649643	0.333333333333	H2BC26 H2BC1 H2BC13	Reproduction
REAC:R-HSA-8939236	0.00912704431771	0.333333333333	H2BC26 H2BC1 H2BC13	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-211000	0.00985761897121	0.333333333333	H2BC26 H2BC1 H2BC13	Gene Silencing by RNA
REAC:R-HSA-9609690	0.0103654411628	0.333333333333	H2BC26 H2BC1 H2BC13	HCMV Early Events
REAC:R-HSA-68875	0.0108901888715	0.333333333333	H2BC26 H2BC1 H2BC13	Mitotic Prophase
REAC:R-HSA-5693567	0.0111589919648	0.333333333333	H2BC26 H2BC1 H2BC13	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-9018519	0.0122778305747	0.333333333333	H2BC26 H2BC1 H2BC13	Estrogen-dependent gene expression
REAC:R-HSA-73886	0.0122778305747	0.333333333333	H2BC26 H2BC1 H2BC13	Chromosome Maintenance
REAC:R-HSA-5693538	0.0128638830436	0.333333333333	H2BC26 H2BC1 H2BC13	Homology Directed Repair
REAC:R-HSA-3214847	0.0128638830436	0.333333333333	H2BC26 H2BC1 H2BC13	HATs acetylate histones
REAC:R-HSA-68867	0.0131636816219	0.333333333333	H2BC26 H2BC1 H2BC13	Assembly of the pre-replicative complex
HPA:0570772	0.0147158526611	0.444444444444	MIER1 H2BC13 H2BC26 CDYL	testis; peritubular cells[>=Medium]
REAC:R-HSA-9609646	0.0171260552969	0.333333333333	H2BC26 H2BC1 H2BC13	HCMV Infection
REAC:R-HSA-69002	0.0189840110493	0.333333333333	H2BC26 H2BC1 H2BC13	DNA Replication Pre-Initiation
REAC:R-HSA-5693532	0.0235262214575	0.333333333333	H2BC26 H2BC1 H2BC13	DNA Double-Strand Break Repair
REAC:R-HSA-69481	0.0239712251002	0.333333333333	H2BC26 H2BC1 H2BC13	G2/M Checkpoints
REAC:R-HSA-212165	0.0297477434643	0.333333333333	H2BC26 H2BC1 H2BC13	Epigenetic regulation of gene expression
REAC:R-HSA-69306	0.031321493924	0.333333333333	H2BC26 H2BC1 H2BC13	DNA Replication
REAC:R-HSA-2559583	0.0318579275589	0.333333333333	H2BC26 H2BC1 H2BC13	Cellular Senescence
REAC:R-HSA-5689880	0.0335032070081	0.333333333333	H2BC26 H2BC1 H2BC13	Ub-specific processing proteases
REAC:R-HSA-8939211	0.0375559727424	0.333333333333	H2BC26 H2BC1 H2BC13	ESR-mediated signaling
HPA:0570771	0.0468950335893	0.444444444444	MIER1 H2BC13 H2BC26 CDYL	testis; peritubular cells[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
MIER1	CDYL	0.998	0.05		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
H2BC26	MIER1	0.998	0.369428571429		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MIER3	MIER1	0.998	0.138		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
H2BC26	MIER3	0.998	0.174407407407		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
H2BC1	MIER3	0.998	0.16	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ARID5B	MIER1	0.997	0.106		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
H2BC1	BAHD1	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
H2BC1	ARID5B	0.997	0.24		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
H2BC1	MIER1	0.996	0.34		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
H2BC26	CDYL	0.996	0.294		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ARID5B	H2BC26	0.996	0.278		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MIER3	CDYL	0.995	0.07		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
H2BC1	CDYL	0.991	0.262		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ARID5B	MIER3	0.988	0.14		bioplex_WMM bioplex3_WMM WMM_only
MIER3	BAHD1	0.983			bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
H2BC1	H2BC13	0.978		mutually_exclusive (Q5TEC6) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
H2BC13	H2BC26	0.971		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
H2BC26	BAHD1	0.968			bioplex3_HEK293 bioplex3_WMM WMM_only
BAHD1	CDYL	0.967			bioplex_WMM bioplex3_WMM WMM_only
ARID5B	BAHD1	0.966			bioplex_WMM bioplex3_WMM WMM_only
BAHD1	MIER1	0.966			bioplex_WMM bioplex3_WMM WMM_only
H2BC26	RBP1	0.951	0.092		bioplex3_HEK293 bioplex3_WMM WMM_only
ARID5B	CDYL	0.951	0.08		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
H2BC13	MIER3	0.324		mutually_exclusive (Q96A08)	bioplex_WMM bioplex3_WMM WMM_only
ARID5B	H2BC13	0.324			bioplex_WMM bioplex3_WMM WMM_only
H2BC13	BAHD1	0.3			bioplex_WMM bioplex3_WMM WMM_only
H2BC13	MIER1	0.162			bioplex_WMM bioplex3_WMM WMM_only
H2BC13	CDYL	0.106			bioplex_WMM bioplex3_WMM WMM_only
RBP1	CDYL	0.088	0.032		bioplex3_WMM WMM_only
RBP1	MIER1	0.085	0.048		bioplex3_WMM WMM_only
ARID5B	RBP1	0.076	0.056		bioplex3_WMM WMM_only
H2BC13	RBP1	0.076			bioplex3_WMM WMM_only
RBP1	BAHD1	0.065			bioplex3_WMM WMM_only
RBP1	MIER3	0.043	0.12		bioplex3_WMM bioplex3_HCT116 WMM_only
H2BC1	RBP1	0.005	0.206		bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
H2BC26	huMAP3_01124.1 huMAP3_01149.1 huMAP3_02525.1 huMAP3_06233.1 huMAP3_06556.1 huMAP3_07203.1 huMAP3_09466.1 huMAP3_09677.1 huMAP3_09728.1 huMAP3_09739.1 huMAP3_10481.1 huMAP3_10862.1 huMAP3_14306.1
CDYL	huMAP3_02906.1 huMAP3_03774.1 huMAP3_06957.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09728.1 huMAP3_10862.1 huMAP3_14306.1
ARID5B	huMAP3_00136.1 huMAP3_01124.1 huMAP3_06233.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09728.1 huMAP3_10862.1 huMAP3_14306.1
RBP1	huMAP3_01124.1 huMAP3_01149.1 huMAP3_02525.1 huMAP3_06233.1 huMAP3_06556.1 huMAP3_07203.1 huMAP3_09466.1 huMAP3_09677.1 huMAP3_09728.1 huMAP3_09739.1 huMAP3_10481.1 huMAP3_10862.1 huMAP3_14198.1
MIER1	huMAP3_02906.1 huMAP3_06957.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09728.1 huMAP3_10862.1 huMAP3_14306.1
BAHD1	huMAP3_02787.1 huMAP3_02906.1 huMAP3_04634.1 huMAP3_06233.1 huMAP3_06556.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09677.1 huMAP3_09728.1 huMAP3_10481.1 huMAP3_10862.1 huMAP3_14306.1
MIER3	huMAP3_01124.1 huMAP3_03774.1 huMAP3_06233.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09728.1 huMAP3_10862.1 huMAP3_14306.1
H2BC13	huMAP3_00920.1 huMAP3_01054.1 huMAP3_01149.1 huMAP3_01213.1 huMAP3_07203.1 huMAP3_08555.1 huMAP3_09466.1 huMAP3_09739.1 huMAP3_10278.1 huMAP3_10505.1 huMAP3_10748.1 huMAP3_10862.1 huMAP3_11626.1
H2BC1	huMAP3_00136.1 huMAP3_04634.1 huMAP3_06556.1 huMAP3_07203.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09677.1 huMAP3_10481.1 huMAP3_10862.1 huMAP3_14306.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07203.1

Complex Portal: CPX-14077