hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07206.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPKAPK2 | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | 5 | UniProt NCBI |
| MAPK11 | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-171007 | 7.68942788458e-05 | 1.0 | MAPKAPK2 MAPK11 | p38MAPK events |
| REAC:R-HSA-167044 | 0.000155497319444 | 1.0 | MAPKAPK2 MAPK11 | Signalling to RAS |
| KEGG:04370 | 0.000207276360454 | 1.0 | MAPKAPK2 MAPK11 | VEGF signaling pathway |
| REAC:R-HSA-450302 | 0.000324664732905 | 1.0 | MAPKAPK2 MAPK11 | activated TAK1 mediates p38 MAPK activation |
| WP:WP2637 | 0.000384350227487 | 1.0 | MAPKAPK2 MAPK11 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-187687 | 0.000555347569442 | 1.0 | MAPKAPK2 MAPK11 | Signalling to ERKs |
| KEGG:04625 | 0.00058037380927 | 1.0 | MAPKAPK2 MAPK11 | C-type lectin receptor signaling pathway |
| REAC:R-HSA-450282 | 0.000743311362176 | 1.0 | MAPKAPK2 MAPK11 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04722 | 0.000804719987643 | 1.0 | MAPKAPK2 MAPK11 | Neurotrophin signaling pathway |
| KEGG:04148 | 0.00123975649005 | 1.0 | MAPKAPK2 MAPK11 | Efferocytosis |
| KEGG:04218 | 0.00158180312723 | 1.0 | MAPKAPK2 MAPK11 | Cellular senescence |
| KEGG:05167 | 0.00228052767407 | 1.0 | MAPKAPK2 MAPK11 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-198725 | 0.0024452380673 | 1.0 | MAPKAPK2 MAPK11 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-450294 | 0.00263149309828 | 1.0 | MAPKAPK2 MAPK11 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.00323126847328 | 1.0 | MAPKAPK2 MAPK11 | Interleukin-17 signaling |
| KEGG:04010 | 0.0047800367266 | 1.0 | MAPKAPK2 MAPK11 | MAPK signaling pathway |
| REAC:R-HSA-975871 | 0.00567479777882 | 1.0 | MAPKAPK2 MAPK11 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.00567479777882 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00567479777882 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-450531 | 0.00581491624249 | 1.0 | MAPKAPK2 MAPK11 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| REAC:R-HSA-975138 | 0.00595674346792 | 1.0 | MAPKAPK2 MAPK11 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0061002794551 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0061002794551 | 1.0 | MAPKAPK2 MAPK11 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-4420097 | 0.00639247771471 | 1.0 | MAPKAPK2 MAPK11 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-168138 | 0.00669151102134 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00699737937497 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00731008277561 | 1.0 | MAPKAPK2 MAPK11 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00731008277561 | 1.0 | MAPKAPK2 MAPK11 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 0.00762962122326 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00762962122326 | 1.0 | MAPKAPK2 MAPK11 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-194138 | 0.00762962122326 | 1.0 | MAPKAPK2 MAPK11 | Signaling by VEGF |
| REAC:R-HSA-187037 | 0.00795599471791 | 1.0 | MAPKAPK2 MAPK11 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-181438 | 0.00795599471791 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00795599471791 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor TLR1:TLR2 Cascade |
| WP:WP382 | 0.00855530406698 | 1.0 | MAPKAPK2 MAPK11 | MAPK signaling pathway |
| REAC:R-HSA-2559580 | 0.00969038789632 | 1.0 | MAPKAPK2 MAPK11 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-166520 | 0.0110061344455 | 1.0 | MAPKAPK2 MAPK11 | Signaling by NTRKs |
| REAC:R-HSA-166016 | 0.0128208394262 | 1.0 | MAPKAPK2 MAPK11 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-168898 | 0.0171064139006 | 1.0 | MAPKAPK2 MAPK11 | Toll-like Receptor Cascades |
| REAC:R-HSA-2559583 | 0.0260158976762 | 1.0 | MAPKAPK2 MAPK11 | Cellular Senescence |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPKAPK2 | MAPK11 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes