hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07209.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMPDL3B | Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) | 5 | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | 5 | UniProt NCBI |
| RGS14 | Regulator of G-protein signaling 14 (RGS14) | 5 | UniProt NCBI |
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP536 | 7.92185909125e-05 | 0.75 | RGS14 GNAI3 GNG11 | Calcium regulation in cardiac cells |
| REAC:R-HSA-418594 | 0.00146681732031 | 0.75 | RGS14 GNAI3 GNG11 | G alpha (i) signalling events |
| REAC:R-HSA-392170 | 0.00194479046925 | 0.5 | GNG11 GNAI3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-392518 | 0.00444848198459 | 0.5 | GNG11 GNAI3 | Signal amplification |
| REAC:R-HSA-977444 | 0.00539805716719 | 0.5 | GNG11 GNAI3 | GABA B receptor activation |
| REAC:R-HSA-991365 | 0.00539805716719 | 0.5 | GNG11 GNAI3 | Activation of GABAB receptors |
| KEGG:04727 | 0.00551283411821 | 0.5 | GNG11 GNAI3 | GABAergic synapse |
| KEGG:05032 | 0.0056793701001 | 0.5 | GNG11 GNAI3 | Morphine addiction |
| REAC:R-HSA-418597 | 0.006081926491 | 0.5 | GNG11 GNAI3 | G alpha (z) signalling events |
| REAC:R-HSA-9660821 | 0.006081926491 | 0.5 | GNG11 GNAI3 | ADORA2B mediated anti-inflammatory cytokines production |
| REAC:R-HSA-9634597 | 0.00643909852192 | 0.5 | GNG11 GNAI3 | GPER1 signaling |
| KEGG:04713 | 0.00654897197861 | 0.5 | GNG11 GNAI3 | Circadian entrainment |
| WP:WP35 | 0.00761604886135 | 0.5 | GNG11 GNAI3 | G protein signaling pathways |
| KEGG:04724 | 0.00806816574582 | 0.5 | GNG11 GNAI3 | Glutamatergic synapse |
| REAC:R-HSA-977443 | 0.00837722051003 | 0.5 | GNG11 GNAI3 | GABA receptor activation |
| KEGG:04726 | 0.00867836513934 | 0.5 | GNG11 GNAI3 | Serotonergic synapse |
| KEGG:04725 | 0.00974438450458 | 0.5 | GNG11 GNAI3 | Cholinergic synapse |
| REAC:R-HSA-388396 | 0.0112517828268 | 0.75 | RGS14 GNAI3 GNG11 | GPCR downstream signalling |
| WP:WP5380 | 0.011545786253 | 0.5 | RGS14 GNAI3 | 5q35 copy number variation |
| KEGG:04926 | 0.014352694406 | 0.5 | GNG11 GNAI3 | Relaxin signaling pathway |
| KEGG:04728 | 0.014619629343 | 0.5 | GNG11 GNAI3 | Dopaminergic synapse |
| KEGG:04371 | 0.015160801965 | 0.5 | GNG11 GNAI3 | Apelin signaling pathway |
| REAC:R-HSA-372790 | 0.0165968987372 | 0.75 | RGS14 GNAI3 GNG11 | Signaling by GPCR |
| KEGG:04723 | 0.017422762868 | 0.5 | GNG11 GNAI3 | Retrograde endocannabinoid signaling |
| WP:WP3929 | 0.0183400443465 | 0.5 | GNG11 GNAI3 | Chemokine signaling pathway |
| REAC:R-HSA-9662851 | 0.019281632575 | 0.5 | GNG11 GNAI3 | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-9664433 | 0.019281632575 | 0.5 | GNG11 GNAI3 | Leishmania parasite growth and survival |
| REAC:R-HSA-9009391 | 0.019281632575 | 0.5 | GNG11 GNAI3 | Extra-nuclear estrogen signaling |
| WP:WP289 | 0.0214906806331 | 0.5 | RGS14 GNG11 | Myometrial relaxation and contraction pathways |
| KEGG:04062 | 0.0237566589162 | 0.5 | GNG11 GNAI3 | Chemokine signaling pathway |
| CORUM:7201 | 0.0249718442456 | 0.25 | GNG11 | GNAS-L-GNB3-GNG11 complex |
| KEGG:05034 | 0.0272860662684 | 0.5 | GNG11 GNAI3 | Alcoholism |
| REAC:R-HSA-111885 | 0.0305753786405 | 0.5 | GNG11 GNAI3 | Opioid Signalling |
| KEGG:04015 | 0.0338381888916 | 0.5 | RGS14 GNAI3 | Rap1 signaling pathway |
| REAC:R-HSA-418555 | 0.0425656343513 | 0.5 | GNG11 GNAI3 | G alpha (s) signalling events |
| KEGG:05163 | 0.0451972531521 | 0.5 | GNG11 GNAI3 | Human cytomegalovirus infection |
| KEGG:05170 | 0.0456663239038 | 0.5 | GNG11 GNAI3 | Human immunodeficiency virus 1 infection |
| CORUM:7083 | 0.049938562206 | 0.25 | GNG11 | GNAI1-GNB3-GNG11 complex |
| CORUM:7195 | 0.049938562206 | 0.25 | GNG11 | GNAS-L-GNB1-GNG11 complex |
| CORUM:7199 | 0.049938562206 | 0.25 | GNG11 | GNAS-L-GNB2-GNG11 complex |
| CORUM:7202 | 0.049938562206 | 0.25 | GNG11 | GNAS-L-GNB4-GNG11 complex |
| CORUM:7203 | 0.049938562206 | 0.25 | GNG11 | GNAS-L-GNB5-GNG11 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GNG11 | GNAI3 | 0.987 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RGS14 | GNAI3 | 0.968 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMPDL3B | GNAI3 | 0.964 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| RGS14 | GNG11 | 0.825 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes