hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07213.1
Complex Portal: CPX-14039
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| KGD4 | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | 3 | UniProt NCBI |
| DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) | 5 | UniProt NCBI |
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | 5 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 4.60395405777e-09 | 0.8 | KGD4 DLST OGDH DLD | oxoglutarate dehydrogenase complex |
| CORUM:7267 | 1.12081835382e-08 | 0.6 | DLD OGDH DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| GO:0045240 | 4.33992010508e-08 | 0.8 | KGD4 DLST OGDH DLD | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 3.12897432326e-07 | 0.8 | KGD4 DLST OGDH DLD | tricarboxylic acid cycle enzyme complex |
| REAC:R-HSA-71064 | 5.14505990951e-07 | 0.6 | DLD OGDH DLST | Lysine catabolism |
| WP:WP2453 | 6.75319260287e-07 | 0.6 | DLD OGDH DLST | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| KEGG:00785 | 7.60322571183e-07 | 0.6 | DLD OGDH DLST | Lipoic acid metabolism |
| WP:WP78 | 9.83834482812e-07 | 0.6 | DLD OGDH DLST | TCA cycle aka Krebs or citric acid cycle |
| KEGG:01210 | 3.77831543883e-06 | 0.6 | DLD OGDH DLST | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 3.77831543883e-06 | 0.6 | DLD OGDH DLST | Citrate cycle (TCA cycle) |
| GO:0018335 | 3.84440695359e-06 | 0.6 | DLD OGDH DLST | protein succinylation |
| GO:0106077 | 3.84440695359e-06 | 0.6 | DLD OGDH DLST | histone succinylation |
| REAC:R-HSA-71403 | 4.14297217289e-06 | 0.6 | DLD OGDH DLST | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 7.16159413456e-06 | 0.6 | DLD OGDH DLST | Glyoxylate metabolism and glycine degradation |
| REAC:R-HSA-71406 | 6.86227830674e-05 | 0.6 | DLD OGDH DLST | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP3925 | 0.000110040620991 | 0.6 | DLD OGDH DLST | Amino acid metabolism |
| KEGG:01200 | 0.000168183083601 | 0.6 | DLD OGDH DLST | Carbon metabolism |
| WP:WP4932 | 0.000170890043196 | 0.6 | DLD OGDH DLST | 7q11 23 copy number variation syndrome |
| GO:0006103 | 0.000274621184043 | 0.6 | KGD4 OGDH DLST | 2-oxoglutarate metabolic process |
| GO:1990204 | 0.000812283184782 | 0.8 | KGD4 DLST OGDH DLD | oxidoreductase complex |
| GO:0006099 | 0.00194127795747 | 0.6 | KGD4 OGDH DLST | tricarboxylic acid cycle |
| KEGG:00380 | 0.00238992944204 | 0.4 | DLD DLST | Tryptophan metabolism |
| REAC:R-HSA-1428517 | 0.00242434232497 | 0.6 | DLD OGDH DLST | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0012401 | 0.00499516489297 | 0.4 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| WP:WP5352 | 0.00631928190743 | 0.4 | DLD DLST | 10q11 21q11 23 copy number variation syndrome |
| KEGG:00310 | 0.0074565122263 | 0.4 | DLD DLST | Lysine degradation |
| GO:0016903 | 0.0094606249379 | 0.6 | KGD4 OGDH DLD | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0004591 | 0.0140440992017 | 0.4 | KGD4 OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71291 | 0.0166452724524 | 0.6 | DLD OGDH DLST | Metabolism of amino acids and derivatives |
| HPA:0570813 | 0.0224403274321 | 0.8 | KGD4 DLST OGDH DLD | testis; spermatogonia cells[High] |
| HPA:0430053 | 0.029921328201 | 0.8 | KGD4 DLST OGDH DLD | seminal vesicle; glandular cells[High] |
| HPA:0090163 | 0.033904891916 | 0.8 | KGD4 DLST OGDH DLD | cerebellum; Purkinje cells[High] |
| HPA:0360053 | 0.035740890287 | 0.8 | KGD4 DLST OGDH DLD | parathyroid gland; glandular cells[High] |
| GO:0043648 | 0.039797089625 | 0.6 | KGD4 OGDH DLST | dicarboxylic acid metabolic process |
| HPA:0340453 | 0.0460879152407 | 0.6 | KGD4 OGDH DLD | ovary; follicle cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.658 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| OGDH | KGD4 | 0.999 | 0.512 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| KGD4 | DLST | 0.999 | 0.336 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| DLD | DLST | 0.998 | 0.736 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM | |
| DLD | KGD4 | 0.998 | 0.346 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| DLD | OGDH | 0.995 | 0.478 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| TCAIM | DLD | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DBT | KGD4 | 0.979 | 0.152 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DBT | DLST | 0.977 | 0.27 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM | |
| DBT | DLD | 0.965 | 0.302 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| TCAIM | DLST | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TCAIM | KGD4 | 0.936 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| DBT | OGDH | 0.477 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| DBT | TCAIM | 0.095 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes