hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07234.1

Complex Portal: CPX-11919

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
HLA-DQA2	HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)	5	UniProt NCBI
DOP1B	Protein dopey-2	5	UniProt NCBI
HLA-DPB1	HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)	5	UniProt NCBI
TMEM219	Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219)	4	UniProt NCBI
TYW1B	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)	4	UniProt NCBI
HLA-DQA1	HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-202430	2.01823692347e-06	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Translocation of ZAP-70 to Immunological synapse
REAC:R-HSA-202427	4.79564882828e-06	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Phosphorylation of CD3 and TCR zeta chains
REAC:R-HSA-389948	5.75389190359e-06	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	PD-1 signaling
REAC:R-HSA-202433	1.42587173715e-05	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Generation of second messenger molecules
REAC:R-HSA-388841	0.000205084871777	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Costimulation by the CD28 family
GO:0002399	0.0002304395259	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC class II protein complex assembly
GO:0002503	0.0002304395259	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	peptide antigen assembly with MHC class II protein complex
GO:0042613	0.000316805542726	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC class II protein complex
REAC:R-HSA-877300	0.000491292751059	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Interferon gamma signaling
GO:0002396	0.000548960443183	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC protein complex assembly
GO:0002501	0.000548960443183	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	peptide antigen assembly with MHC protein complex
REAC:R-HSA-202424	0.000792051133325	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Downstream TCR signaling
KEGG:05310	0.000986043292545	0.333333333333	HLA-DPB1 HLA-DQA2	Asthma
GO:0042611	0.0010743908712	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC protein complex
REAC:R-HSA-202403	0.00134198628361	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	TCR signaling
REAC:R-HSA-2132295	0.00180643378259	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC class II antigen presentation
GO:0023026	0.00218580514948	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC class II protein complex binding
KEGG:05330	0.00254021895382	0.333333333333	HLA-DPB1 HLA-DQA2	Allograft rejection
GO:0019886	0.00254971303757	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of exogenous peptide antigen via MHC class II
KEGG:04672	0.00273512084395	0.333333333333	HLA-DPB1 HLA-DQA2	Intestinal immune network for IgA production
GO:0098553	0.00295184433846	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	lumenal side of endoplasmic reticulum membrane
KEGG:05332	0.00336278970932	0.333333333333	HLA-DPB1 HLA-DQA2	Graft-versus-host disease
GO:0002495	0.00387837112504	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of peptide antigen via MHC class II
KEGG:04940	0.00429978170568	0.333333333333	HLA-DPB1 HLA-DQA2	Type I diabetes mellitus
GO:0002504	0.00440656064028	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0042605	0.00440656064028	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	peptide antigen binding
GO:0002478	0.00560226816097	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of exogenous peptide antigen
GO:0023023	0.00560226816097	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	MHC protein complex binding
KEGG:05320	0.00563154229257	0.333333333333	HLA-DPB1 HLA-DQA2	Autoimmune thyroid disease
REAC:R-HSA-913531	0.00604240808777	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	Interferon Signaling
KEGG:05321	0.00651602067746	0.333333333333	HLA-DPB1 HLA-DQA2	Inflammatory bowel disease
GO:0098576	0.00777254411354	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	lumenal side of membrane
GO:0019884	0.00860399003151	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of exogenous antigen
KEGG:05150	0.00918692149975	0.333333333333	HLA-DPB1 HLA-DQA2	Staphylococcus aureus infection
KEGG:05416	0.0103053165388	0.333333333333	HLA-DPB1 HLA-DQA2	Viral myocarditis
KEGG:04640	0.0123104747863	0.333333333333	HLA-DPB1 HLA-DQA2	Hematopoietic cell lineage
KEGG:04612	0.0131618550544	0.333333333333	HLA-DPB1 HLA-DQA2	Antigen processing and presentation
KEGG:05140	0.0135980974704	0.333333333333	HLA-DPB1 HLA-DQA2	Leishmaniasis
KEGG:05323	0.0163630378499	0.333333333333	HLA-DPB1 HLA-DQA2	Rheumatoid arthritis
KEGG:04658	0.0193802025824	0.333333333333	HLA-DPB1 HLA-DQA2	Th1 and Th2 cell differentiation
WP:WP2328	0.0220152039288	0.333333333333	HLA-DPB1 HLA-DQA2	Allograft rejection
KEGG:04659	0.0286526780492	0.333333333333	HLA-DPB1 HLA-DQA2	Th17 cell differentiation
GO:0003823	0.0289892662643	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen binding
KEGG:05145	0.029291198851	0.333333333333	HLA-DPB1 HLA-DQA2	Toxoplasmosis
GO:0012507	0.0330200031842	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	ER to Golgi transport vesicle membrane
GO:0005802	0.0346435855588	0.666666666667	HLA-DPB1 HLA-DQA1 HLA-DQA2 DOP1B	trans-Golgi network
KEGG:04514	0.0382199966286	0.333333333333	HLA-DPB1 HLA-DQA2	Cell adhesion molecules
GO:0048002	0.0397388592171	0.5	HLA-DPB1 HLA-DQA2 HLA-DQA1	antigen processing and presentation of peptide antigen
KEGG:05322	0.0412011786405	0.333333333333	HLA-DPB1 HLA-DQA2	Systemic lupus erythematosus

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
HLA-DQA2	HLA-DQA1	0.998	0.352	bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DPB1	HLA-DQA1	0.994	0.342	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TYW1B	HLA-DQA1	0.985		bioplex3_WMM bioplex3_HCT116 WMM_only
DOP1B	HLA-DQA1	0.984	0.078	bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DQA1	TMEM219	0.963		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TYW1B	HLA-DQA2	0.73		bioplex3_WMM WMM_only
DOP1B	HLA-DQA2	0.703	0.054	bioplex3_WMM WMM_only
TYW1B	DOP1B	0.153		bioplex3_WMM WMM_only
HLA-DPB1	TYW1B	0.072		bioplex_WMM bioplex3_WMM WMM_only
HLA-DQA2	TMEM219	0.055		bioplex3_WMM WMM_only
TYW1B	TMEM219	0.049		bioplex3_WMM WMM_only
HLA-DPB1	HLA-DQA2	0.045	0.406	bioplex3_WMM WMM_only
HLA-DPB1	TMEM219	0.027		bioplex_WMM bioplex3_WMM WMM_only
DOP1B	TMEM219	0.026		bioplex3_WMM WMM_only
HLA-DPB1	DOP1B	0.013	0.106	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
HLA-DQA2	huMAP3_03754.1 huMAP3_07234.1 huMAP3_08674.1 huMAP3_14836.1
DOP1B	huMAP3_03654.1 huMAP3_03685.1 huMAP3_03754.1 huMAP3_05476.1 huMAP3_07234.1 huMAP3_08511.1 huMAP3_08674.1 huMAP3_08847.1 huMAP3_09862.1 huMAP3_11067.1
HLA-DPB1	huMAP3_00587.1 huMAP3_03754.1 huMAP3_05213.1 huMAP3_05482.1 huMAP3_05974.1 huMAP3_06650.1 huMAP3_07234.1 huMAP3_08884.1 huMAP3_09938.1
TMEM219	huMAP3_07234.1 huMAP3_07396.1 huMAP3_08183.1 huMAP3_08674.1 huMAP3_08835.1 huMAP3_10007.1 huMAP3_14119.1 huMAP3_14700.1 huMAP3_15126.1
TYW1B	huMAP3_01431.1 huMAP3_03754.1 huMAP3_05652.1 huMAP3_07234.1 huMAP3_09757.1 huMAP3_10409.1 huMAP3_14530.1
HLA-DQA1	huMAP3_03754.1 huMAP3_07234.1 huMAP3_08674.1 huMAP3_14836.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07234.1

Complex Portal: CPX-11919