hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07249.1
Complex Portal: CPX-15051
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF123 | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) | 5 | UniProt NCBI |
| INSL3 | Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] | 5 | UniProt NCBI |
| UBAC1 | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | 5 | UniProt NCBI |
| NMB | Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:386 | 5.12628525639e-06 | 0.5 | UBAC1 RNF123 | Ubiquitin E3 ligase (UBADC1, RNF123) |
| KEGG:04080 | 0.0428875882852 | 0.5 | NMB INSL3 | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-375276 | 0.046351696636 | 0.5 | NMB INSL3 | Peptide ligand-binding receptors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF123 | UBAC1 | 0.999 | 0.144 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NMB | UBAC1 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NMB | RNF123 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| INSL3 | RNF123 | 0.978 |
mutually_exclusive (Q9BSL1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| INSL3 | UBAC1 | 0.96 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes