hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07263.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | 5 | UniProt NCBI |
| ATF7IP | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | 5 | UniProt NCBI |
| ATF7IP2 | Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2749 | 3.41752350426e-06 | 0.666666666667 | SETDB1 ATF7IP | SETDB1-containing HMTase complex |
| CORUM:2238 | 3.41752350426e-06 | 0.666666666667 | SETDB1 ATF7IP | MBD1-MCAF1-SETDB1 complex |
| GO:0090309 | 1.15344049292e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | positive regulation of DNA methylation-dependent heterochromatin formation |
| GO:0031453 | 2.11464090368e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | positive regulation of heterochromatin formation |
| GO:0120263 | 2.11464090368e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | positive regulation of heterochromatin organization |
| GO:1905269 | 2.74903317479e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | positive regulation of chromatin organization |
| GO:0090308 | 3.49876949518e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | regulation of DNA methylation-dependent heterochromatin formation |
| GO:0031445 | 9.31403198031e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | regulation of heterochromatin formation |
| GO:0120261 | 9.31403198031e-05 | 1.0 | SETDB1 ATF7IP2 ATF7IP | regulation of heterochromatin organization |
| GO:0006346 | 0.000170228592746 | 1.0 | SETDB1 ATF7IP2 ATF7IP | DNA methylation-dependent heterochromatin formation |
| GO:1902275 | 0.000432059584639 | 1.0 | SETDB1 ATF7IP2 ATF7IP | regulation of chromatin organization |
| GO:0140718 | 0.000432059584639 | 1.0 | SETDB1 ATF7IP2 ATF7IP | facultative heterochromatin formation |
| GO:0031507 | 0.00675723888767 | 1.0 | SETDB1 ATF7IP2 ATF7IP | heterochromatin formation |
| GO:0070828 | 0.00915870199393 | 1.0 | SETDB1 ATF7IP2 ATF7IP | heterochromatin organization |
| GO:0045814 | 0.0146194737676 | 1.0 | SETDB1 ATF7IP2 ATF7IP | negative regulation of gene expression, epigenetic |
| REAC:R-HSA-3214841 | 0.015485676782 | 0.666666666667 | SETDB1 ATF7IP | PKMTs methylate histone lysines |
| GO:2001252 | 0.0180186629002 | 1.0 | SETDB1 ATF7IP2 ATF7IP | positive regulation of chromosome organization |
| CORUM:2759 | 0.0249718442456 | 0.333333333333 | ATF7IP | MBD1-MCAF complex |
| CORUM:6422 | 0.0499402709677 | 0.333333333333 | SETDB1 | SETDB1-DNMT3A complex |
| CORUM:2233 | 0.0499402709677 | 0.333333333333 | SETDB1 | Replication-coupled CAF-1-MBD1-ETDB1 complex |
| CORUM:2237 | 0.0499402709677 | 0.333333333333 | ATF7IP2 | SP1-MCAF2 complex |
| CORUM:6345 | 0.0499402709677 | 0.333333333333 | SETDB1 | ZNF304-corepressor complex |
| CORUM:6423 | 0.0499402709677 | 0.333333333333 | SETDB1 | SETDB1-DNMT3B complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SETDB1 | ATF7IP | 1.0 | 0.474 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () Malo fraction |
| ATF7IP2 | SETDB1 | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF7IP2 | ATF7IP | 0.335 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SETDB1 | huMAP3_04847.1 huMAP3_05859.1 huMAP3_07263.1 huMAP3_12714.1 huMAP3_15236.1 |
| ATF7IP | huMAP3_04847.1 huMAP3_05859.1 huMAP3_07263.1 huMAP3_12714.1 huMAP3_15236.1 |
| ATF7IP2 | huMAP3_02693.1 huMAP3_07263.1 huMAP3_11202.1 huMAP3_12714.1 huMAP3_13761.1 huMAP3_13839.1 |