hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07276.1
Complex Portal: CPX-20318
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WBP2 | WW domain-binding protein 2 (WBP-2) | 5 | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 5 | UniProt NCBI |
| VASP | Vasodilator-stimulated phosphoprotein (VASP) | 5 | UniProt NCBI |
| ZYX | Zyxin (Zyxin-2) | 5 | UniProt NCBI |
| TACC3 | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | 5 | UniProt NCBI |
| ENAH | Protein enabled homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202433 | 1.42587173715e-05 | 0.5 | VASP EVL ENAH | Generation of second messenger molecules |
| GO:0005522 | 0.0002304395259 | 0.5 | VASP EVL ENAH | profilin binding |
| REAC:R-HSA-202403 | 0.00134198628361 | 0.5 | VASP EVL ENAH | TCR signaling |
| KEGG:04015 | 0.00145281635598 | 0.5 | VASP EVL ENAH | Rap1 signaling pathway |
| REAC:R-HSA-376176 | 0.0104146574261 | 0.5 | VASP EVL ENAH | Signaling by ROBO receptors |
| HPA:0160251 | 0.0253947209828 | 1.0 | VASP TACC3 ENAH WBP2 ZYX EVL | endometrium 1; cells in endometrial stroma[>=Low] |
| WP:WP185 | 0.0346027913493 | 0.333333333333 | VASP ZYX | Integrin mediated cell adhesion |
| HPA:0530721 | 0.0362409368932 | 1.0 | VASP TACC3 ENAH WBP2 ZYX EVL | spleen; cells in white pulp[>=Low] |
| GO:0017124 | 0.0397388592171 | 0.5 | VASP EVL ENAH | SH3 domain binding |
| CORUM:6731 | 0.0499436884912 | 0.166666666667 | VASP | VASP-CXCR2 complex, CXCL8 stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EVL | ENAH | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction | ||
| VASP | ENAH | 1.0 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EVL | VASP | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | ||
| ENAH | ZYX | 0.996 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| TACC3 | ENAH | 0.989 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| TACC3 | VASP | 0.989 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| VASP | ZYX | 0.97 | 0.424 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| WBP2 | VASP | 0.957 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TACC3 | EVL | 0.63 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| EVL | WBP2 | 0.419 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WBP2 | ENAH | 0.204 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| WBP2 | ZYX | 0.112 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| TACC3 | ZYX | 0.059 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EVL | ZYX | 0.057 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| TACC3 | WBP2 | 0.009 | 0.0545714285714 | bioplex_WMM WMM_only |
Related Complexes