hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07286.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARRB1 | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | 5 | UniProt NCBI |
| ARRB2 | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) | 5 | UniProt NCBI |
| SAG | S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) | 5 | UniProt NCBI |
| BRPF1 | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | 5 | UniProt NCBI |
| TCOF1 | Treacle protein (Treacher Collins syndrome protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4941 | 0.000535373329556 | 0.5 | ARRB1 ARRB2 | GPR143 in melanocytes and retinal pigment epithelium cells |
| REAC:R-HSA-5635838 | 0.000798898068561 | 0.5 | ARRB1 ARRB2 | Activation of SMO |
| WP:WP4871 | 0.00126323103486 | 0.5 | ARRB1 ARRB2 | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP4249 | 0.00169541860832 | 0.5 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| KEGG:04340 | 0.00247340401034 | 0.5 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| KEGG:04929 | 0.00247340401034 | 0.5 | ARRB1 ARRB2 | GnRH secretion |
| REAC:R-HSA-2122948 | 0.00282403231951 | 0.5 | ARRB1 ARRB2 | Activated NOTCH1 Transmits Signal to the Nucleus |
| REAC:R-HSA-456926 | 0.00359044851421 | 0.5 | ARRB1 ARRB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-6802948 | 0.00444848198459 | 0.5 | ARRB1 ARRB2 | Signaling by high-kinase activity BRAF mutants |
| WP:WP5094 | 0.00561306746582 | 0.5 | ARRB1 ARRB2 | Orexin receptor pathway |
| KEGG:05032 | 0.0056793701001 | 0.5 | ARRB1 ARRB2 | Morphine addiction |
| REAC:R-HSA-5674135 | 0.00573491177379 | 0.5 | ARRB1 ARRB2 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 0.006081926491 | 0.5 | ARRB1 ARRB2 | Signaling by RAF1 mutants |
| WP:WP2355 | 0.00703973989842 | 0.5 | ARRB1 ARRB2 | Corticotropin releasing hormone signaling pathway |
| REAC:R-HSA-9649948 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling by moderate kinase activity BRAF mutants |
| KEGG:04740 | 0.00826911293642 | 0.5 | ARRB1 ARRB2 | Olfactory transduction |
| KEGG:04928 | 0.00847251296121 | 0.5 | ARRB1 ARRB2 | Parathyroid hormone synthesis, secretion and action |
| WP:WP4659 | 0.0138131669346 | 0.5 | ARRB1 ARRB2 | Gastrin signaling pathway |
| KEGG:04926 | 0.014352694406 | 0.5 | ARRB1 ARRB2 | Relaxin signaling pathway |
| KEGG:04728 | 0.014619629343 | 0.5 | ARRB1 ARRB2 | Dopaminergic synapse |
| REAC:R-HSA-6802952 | 0.0157112703152 | 0.5 | ARRB1 ARRB2 | Signaling by BRAF and RAF1 fusions |
| WP:WP536 | 0.015715675352 | 0.5 | ARRB1 ARRB2 | Calcium regulation in cardiac cells |
| GO:0031701 | 0.0168521501606 | 0.5 | ARRB1 ARRB2 | angiotensin receptor binding |
| REAC:R-HSA-1980143 | 0.0174510452107 | 0.5 | ARRB1 ARRB2 | Signaling by NOTCH1 |
| WP:WP3929 | 0.0183400443465 | 0.5 | ARRB1 ARRB2 | Chemokine signaling pathway |
| WP:WP289 | 0.0214906806331 | 0.5 | ARRB1 ARRB2 | Myometrial relaxation and contraction pathways |
| KEGG:04062 | 0.0237566589162 | 0.5 | ARRB1 ARRB2 | Chemokine signaling pathway |
| CORUM:1297 | 0.0249718442456 | 0.25 | ARRB2 | MKK4-ARRB2-ASK1 complex |
| REAC:R-HSA-6802957 | 0.0253175164514 | 0.5 | ARRB1 ARRB2 | Oncogenic MAPK signaling |
| REAC:R-HSA-5632684 | 0.0297941212351 | 0.5 | ARRB1 ARRB2 | Hedgehog 'on' state |
| KEGG:05207 | 0.0326315237827 | 0.5 | ARRB1 ARRB2 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-418555 | 0.0425656343513 | 0.5 | ARRB1 ARRB2 | G alpha (s) signalling events |
| REAC:R-HSA-8856825 | 0.0444386798825 | 0.5 | ARRB1 ARRB2 | Cargo recognition for clathrin-mediated endocytosis |
| CORUM:1298 | 0.049938562206 | 0.25 | ARRB2 | MKK4-ARRB2-JNK3 complex |
| CORUM:6805 | 0.049938562206 | 0.25 | ARRB2 | S1PR1-beta-arrestin 2 complex, ApoM(+)HDL-S1P stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ARRB1 | SAG | 0.999 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCOF1 | ARRB2 | 0.99 | 0.0827111111111 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ARRB2 | ARRB1 | 0.986 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TCOF1 | ARRB1 | 0.985 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARRB2 | BRPF1 | 0.975 | 0.113666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| BRPF1 | ARRB1 | 0.968 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| BRPF1 | SAG | 0.303 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| TCOF1 | BRPF1 | 0.291 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TCOF1 | SAG | 0.283 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
| ARRB2 | SAG | 0.213 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes