hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07305.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
| ERRFI1 | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | 5 | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4928 | 0.000914914863609 | 0.333333333333 | SOS2 GAREM2 | MAPK pathway in congenital thyroid cancer |
| KEGG:05206 | 0.00103019356944 | 0.5 | GLS2 SOS2 GRB2 | MicroRNAs in cancer |
| WP:WP437 | 0.00131518658903 | 0.5 | ERRFI1 SOS2 GRB2 | EGF EGFR signaling pathway |
| REAC:R-HSA-8983432 | 0.00200991204249 | 0.333333333333 | GRB2 SOS2 | Interleukin-15 signaling |
| WP:WP422 | 0.00352059040085 | 0.333333333333 | GRB2 SOS2 | MAPK cascade |
| WP:WP4535 | 0.00703705758996 | 0.333333333333 | GRB2 SOS2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05213 | 0.00955265238281 | 0.333333333333 | GRB2 SOS2 | Endometrial cancer |
| KEGG:04664 | 0.00992545203512 | 0.333333333333 | GRB2 SOS2 | Fc epsilon RI signaling pathway |
| KEGG:05221 | 0.0123104747863 | 0.333333333333 | GRB2 SOS2 | Acute myeloid leukemia |
| REAC:R-HSA-451927 | 0.0135559590666 | 0.333333333333 | GRB2 SOS2 | Interleukin-2 family signaling |
| KEGG:04917 | 0.0135980974704 | 0.333333333333 | GRB2 SOS2 | Prolactin signaling pathway |
| KEGG:05211 | 0.0149489869659 | 0.333333333333 | GRB2 SOS2 | Renal cell carcinoma |
| WP:WP4205 | 0.0159206501541 | 0.333333333333 | GRB2 SOS2 | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 0.0159206501541 | 0.333333333333 | GRB2 SOS2 | Endometrial cancer |
| KEGG:04912 | 0.0163630378499 | 0.333333333333 | GRB2 SOS2 | GnRH signaling pathway |
| KEGG:05214 | 0.0163630378499 | 0.333333333333 | GRB2 SOS2 | Glioma |
| KEGG:04662 | 0.0163630378499 | 0.333333333333 | GRB2 SOS2 | B cell receptor signaling pathway |
| KEGG:05223 | 0.0163630378499 | 0.333333333333 | GRB2 SOS2 | Non-small cell lung cancer |
| WP:WP5293 | 0.0170615762461 | 0.333333333333 | GRB2 SOS2 | Acute myeloid leukemia |
| WP:WP4685 | 0.0176466803728 | 0.333333333333 | GRB2 SOS2 | Melanoma |
| KEGG:04540 | 0.0178401447976 | 0.333333333333 | GRB2 SOS2 | Gap junction |
| KEGG:01521 | 0.0193802025824 | 0.333333333333 | GRB2 SOS2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.0193802025824 | 0.333333333333 | GRB2 SOS2 | Chronic myeloid leukemia |
| KEGG:04012 | 0.0204418285401 | 0.333333333333 | GRB2 SOS2 | ErbB signaling pathway |
| KEGG:05210 | 0.0215313547967 | 0.333333333333 | GRB2 SOS2 | Colorectal cancer |
| WP:WP4255 | 0.0220152039288 | 0.333333333333 | GRB2 SOS2 | Non small cell lung cancer |
| KEGG:01522 | 0.0237939838034 | 0.333333333333 | GRB2 SOS2 | Endocrine resistance |
| KEGG:05231 | 0.0243770301627 | 0.333333333333 | GRB2 SOS2 | Choline metabolism in cancer |
| KEGG:05215 | 0.0286526780492 | 0.333333333333 | GRB2 SOS2 | Prostate cancer |
| WP:WP2261 | 0.0290813206156 | 0.333333333333 | ERRFI1 GRB2 | Glioblastoma signaling pathways |
| KEGG:04915 | 0.0299366365218 | 0.333333333333 | GRB2 SOS2 | Estrogen signaling pathway |
| WP:WP4806 | 0.0306106562527 | 0.333333333333 | GRB2 SOS2 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP673 | 0.0321785953671 | 0.333333333333 | GRB2 SOS2 | ErbB signaling pathway |
| KEGG:04722 | 0.0353486809432 | 0.333333333333 | GRB2 SOS2 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0353486809432 | 0.333333333333 | GRB2 SOS2 | Growth hormone synthesis, secretion and action |
| KEGG:04660 | 0.0374918580993 | 0.333333333333 | GRB2 SOS2 | T cell receptor signaling pathway |
| WP:WP4321 | 0.0405958365711 | 0.333333333333 | GRB2 SOS2 | Thermogenesis |
| KEGG:04926 | 0.0412011786405 | 0.333333333333 | GRB2 SOS2 | Relaxin signaling pathway |
| KEGG:04650 | 0.0419636118509 | 0.333333333333 | GRB2 SOS2 | Natural killer cell mediated cytotoxicity |
| KEGG:04068 | 0.045081780015 | 0.333333333333 | GRB2 SOS2 | FoxO signaling pathway |
| KEGG:04072 | 0.0474921555213 | 0.333333333333 | GRB2 SOS2 | Phospholipase D signaling pathway |
| CORUM:2895 | 0.0499436884912 | 0.166666666667 | GRB2 | SHC-GRB2 complex |
| CORUM:2892 | 0.0499436884912 | 0.166666666667 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2540 | 0.0499436884912 | 0.166666666667 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:3096 | 0.0499436884912 | 0.166666666667 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
| WP:WP710 | 0.049971715525 | 0.333333333333 | GRB2 SOS2 | DNA damage response only ATM dependent |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ERRFI1 | GRB2 | 0.998 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GRB2 | GAREM2 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SHC1 | GRB2 | 0.976 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| GLS2 | GRB2 | 0.974 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SOS2 | ERRFI1 | 0.844 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| SHC1 | GAREM2 | 0.796 | bioplex3_WMM WMM_only | |
| SHC1 | SOS2 | 0.675 | bioplex3_WMM WMM_only | |
| C16orf96 | ERRFI1 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | GAREM2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | SOS2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| ERRFI1 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | ERRFI1 | 0.343 | bioplex3_WMM WMM_only | |
| SHC1 | C16orf96 | 0.131 | bioplex3_WMM WMM_only | |
| GLS2 | GAREM2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | GLS2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| ERRFI1 | GLS2 | 0.11 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| SOS2 | GLS2 | 0.11 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only |
| SHC1 | GLS2 | 0.013 | bioplex3_WMM WMM_only |
Related Complexes