hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07315.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 2.33868713081e-10 | 1.0 | QRSL1 GATC GATB | GATB-GATC-QRSL1 complex |
| GO:0050567 | 9.61200410764e-08 | 1.0 | QRSL1 GATC GATB | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 9.61200410764e-08 | 1.0 | QRSL1 GATC GATB | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 9.61200410764e-08 | 1.0 | QRSL1 GATC GATB | glutaminyl-tRNAGln biosynthesis via transamidation |
| KEGG:00970 | 6.44683384198e-07 | 1.0 | QRSL1 GATC GATB | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 2.25146042161e-06 | 1.0 | QRSL1 GATC GATB | Decreased circulating cortisol level |
| GO:0016884 | 8.07408345042e-06 | 1.0 | QRSL1 GATC GATB | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| HP:0008207 | 1.31450650769e-05 | 1.0 | QRSL1 GATC GATB | Primary adrenal insufficiency |
| HP:0011731 | 1.59541949261e-05 | 1.0 | QRSL1 GATC GATB | Abnormality of circulating cortisol level |
| HP:0012111 | 1.69725477937e-05 | 1.0 | QRSL1 GATC GATB | Abnormality of circulating glucocorticoid level |
| HP:0001790 | 2.8151048787e-05 | 1.0 | QRSL1 GATC GATB | Nonimmune hydrops fetalis |
| HP:0000846 | 6.08760260151e-05 | 1.0 | QRSL1 GATC GATB | Adrenal insufficiency |
| HP:0011733 | 0.000153143471932 | 1.0 | QRSL1 GATC GATB | Abnormality of adrenal physiology |
| HP:0001789 | 0.000181791573904 | 1.0 | QRSL1 GATC GATB | Hydrops fetalis |
| HP:0001622 | 0.00041322178848 | 1.0 | QRSL1 GATC GATB | Premature birth |
| HP:0000834 | 0.000696601854446 | 1.0 | QRSL1 GATC GATB | Abnormality of the adrenal glands |
| HP:0003128 | 0.000786798822721 | 1.0 | QRSL1 GATC GATB | Lactic acidosis |
| GO:0016879 | 0.000949666005835 | 1.0 | QRSL1 GATC GATB | ligase activity, forming carbon-nitrogen bonds |
| GO:0043039 | 0.00102463963787 | 1.0 | QRSL1 GATC GATB | tRNA aminoacylation |
| GO:0043038 | 0.00102463963787 | 1.0 | QRSL1 GATC GATB | amino acid activation |
| HP:0001943 | 0.00155778546571 | 1.0 | QRSL1 GATC GATB | Hypoglycemia |
| HP:0003236 | 0.00247851933918 | 1.0 | QRSL1 GATC GATB | Elevated circulating creatine kinase concentration |
| HP:0034058 | 0.00256598944251 | 1.0 | QRSL1 GATC GATB | Abnormal fetal morphology |
| HP:0011015 | 0.00287237856804 | 1.0 | QRSL1 GATC GATB | Abnormal blood glucose concentration |
| HP:0040081 | 0.00290429388546 | 1.0 | QRSL1 GATC GATB | Abnormal circulating creatine kinase concentration |
| HP:0011021 | 0.0030014565259 | 1.0 | QRSL1 GATC GATB | Abnormality of circulating enzyme level |
| HP:0003117 | 0.00592643267317 | 1.0 | QRSL1 GATC GATB | Abnormal circulating hormone concentration |
| HP:0001941 | 0.00651157857729 | 1.0 | QRSL1 GATC GATB | Acidosis |
| HP:0004360 | 0.00779492747058 | 1.0 | QRSL1 GATC GATB | Abnormality of acid-base homeostasis |
| HP:0011924 | 0.00888120343534 | 0.666666666667 | QRSL1 GATC | Decreased activity of mitochondrial complex III |
| HP:0034057 | 0.0155653417329 | 1.0 | QRSL1 GATC GATB | Fetal anomaly |
| HP:0008347 | 0.0187458629677 | 0.666666666667 | QRSL1 GATC | Decreased activity of mitochondrial complex IV |
| HP:0001903 | 0.0189203502844 | 1.0 | QRSL1 GATC GATB | Anemia |
| KEGG:01100 | 0.0189521995452 | 1.0 | QRSL1 GATC GATB | Metabolic pathways |
| GO:0140101 | 0.0201788647033 | 1.0 | QRSL1 GATC GATB | catalytic activity, acting on a tRNA |
| HP:0001511 | 0.0218534403487 | 1.0 | QRSL1 GATC GATB | Intrauterine growth retardation |
| HP:0010876 | 0.0228523059604 | 1.0 | QRSL1 GATC GATB | Abnormal circulating protein concentration |
| HP:0001877 | 0.0249404281241 | 1.0 | QRSL1 GATC GATB | Abnormal erythrocyte morphology |
| HP:0000969 | 0.0261690318913 | 1.0 | QRSL1 GATC GATB | Edema |
| HP:0011014 | 0.0281593358932 | 1.0 | QRSL1 GATC GATB | Abnormal glucose homeostasis |
| GO:0032543 | 0.030542143052 | 1.0 | QRSL1 GATC GATB | mitochondrial translation |
| HP:0011032 | 0.0360877888219 | 1.0 | QRSL1 GATC GATB | Abnormality of fluid regulation |
| HP:0003811 | 0.0418708017344 | 0.666666666667 | QRSL1 GATC | Neonatal death |
| GO:0016874 | 0.0449053607901 | 1.0 | QRSL1 GATC GATB | ligase activity |
| HP:0011923 | 0.0493566712329 | 0.666666666667 | QRSL1 GATC | Decreased activity of mitochondrial complex I |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GATC | GATB | 0.999 | 0.764 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | GATB | 0.999 | 0.296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
Related Complexes