hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07327.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UFL1 | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | 5 | UniProt NCBI |
| DDRGK1 | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | 5 | UniProt NCBI |
| UFM1 | Ubiquitin-fold modifier 1 | 5 | UniProt NCBI |
| UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990564 | 1.31563155046e-10 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | protein polyufmylation |
| GO:1990592 | 1.31563155046e-10 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | protein K69-linked ufmylation |
| GO:0071569 | 3.94689465137e-10 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | protein ufmylation |
| GO:0061709 | 6.26240618018e-08 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | reticulophagy |
| GO:1903008 | 0.00045202142534 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | organelle disassembly |
| GO:0033146 | 0.000680215375943 | 0.75 | DDRGK1 UFL1 UFM1 | regulation of intracellular estrogen receptor signaling pathway |
| GO:0034976 | 0.000709501150068 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | response to endoplasmic reticulum stress |
| GO:0071568 | 0.0028092043205 | 0.5 | UFC1 UFL1 | UFM1 transferase activity |
| GO:0030520 | 0.00350727150095 | 0.75 | DDRGK1 UFL1 UFM1 | intracellular estrogen receptor signaling pathway |
| GO:0016236 | 0.00595686338265 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | macroautophagy |
| GO:0033143 | 0.0089837173405 | 0.75 | DDRGK1 UFL1 UFM1 | regulation of intracellular steroid hormone receptor signaling pathway |
| GO:1903895 | 0.0168521501606 | 0.5 | DDRGK1 UFL1 | negative regulation of IRE1-mediated unfolded protein response |
| GO:0022411 | 0.0293508377622 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | cellular component disassembly |
| GO:0006914 | 0.0431855442038 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | autophagy |
| GO:0061919 | 0.0431855442038 | 1.0 | DDRGK1 UFL1 UFC1 UFM1 | process utilizing autophagic mechanism |
| GO:0030518 | 0.0496619752722 | 0.75 | DDRGK1 UFL1 UFM1 | intracellular steroid hormone receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFL1 | DDRGK1 | 1.0 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| UFL1 | UFM1 | 0.998 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| DDRGK1 | UFM1 | 0.994 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DDRGK1 | UFC1 | 0.994 | 0.28 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| UFL1 | UFC1 | 0.989 | 0.104 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| UFM1 | UFC1 | 0.97 | 0.168 | hein_WMM bioplex_WMM bioplex3_WMM fraction |
Related Complexes