List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_07331.1

Confidence: Very High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RGPD5	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	4	UniProt   NCBI
UBE2I	SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)	5	UniProt   NCBI
RGPD1	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	3	UniProt   NCBI
RAN	GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)	5	UniProt   NCBI
NEMP1	Nuclear envelope integral membrane protein 1	5	UniProt   NCBI
RANBP1	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	5	UniProt   NCBI
DLGAP5	Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)	5	UniProt   NCBI
B2M	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	5	UniProt   NCBI
NUSAP1	Nucleolar and spindle-associated protein 1 (NuSAP)	5	UniProt   NCBI
RGPD2	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	3	UniProt   NCBI
NUTF2	Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)	5	UniProt   NCBI
RCC1	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	5	UniProt   NCBI
SUMO2	Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)	5	UniProt   NCBI
SUMO1	Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)	5	UniProt   NCBI
RANGAP1	Ran GTPase-activating protein 1 (RanGAP1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9615933	2.66835691727e-09	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Postmitotic nuclear pore complex (NPC) reformation
GO:0005643	1.22831591715e-08	0.538461538462	RAN NUTF2 UBE2I RANBP1 RGPD2 SUMO1 RANGAP1	nuclear pore
REAC:R-HSA-9793242	1.50220392065e-07	0.230769230769	SUMO1 UBE2I RANGAP1	SUMOylation of nuclear envelope proteins
REAC:R-HSA-2995410	5.94492755336e-07	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Nuclear Envelope (NE) Reassembly
KEGG:03013	1.00513503193e-06	0.384615384615	SUMO2 SUMO1 UBE2I RANGAP1 RAN	Nucleocytoplasmic transport
REAC:R-HSA-3065678	2.99978384253e-06	0.230769230769	SUMO2 UBE2I SUMO1	SUMO is transferred from E1 to E2 (UBE2I, UBC9)
REAC:R-HSA-165054	3.64621407237e-06	0.307692307692	RANBP1 RAN RANGAP1 RCC1	Rev-mediated nuclear export of HIV RNA
REAC:R-HSA-177243	4.69772071441e-06	0.307692307692	RANBP1 RAN RANGAP1 RCC1	Interactions of Rev with host cellular proteins
GO:0005635	5.92608370972e-06	0.615384615385	RAN NUTF2 UBE2I RANBP1 SUMO1 NEMP1 RGPD2 RANGAP1	nuclear envelope
REAC:R-HSA-4615885	1.1293428452e-05	0.307692307692	SUMO2 UBE2I RANGAP1 SUMO1	SUMOylation of DNA replication proteins
REAC:R-HSA-3215018	1.25797000422e-05	0.230769230769	SUMO2 UBE2I SUMO1	Processing and activation of SUMO
REAC:R-HSA-162909	1.4058266735e-05	0.384615384615	RANBP1 RCC1 RAN RANGAP1 B2M	Host Interactions of HIV factors
REAC:R-HSA-3232118	6.79304263505e-05	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of transcription factors
REAC:R-HSA-4090294	0.00010141817735	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of intracellular receptors
CORUM:7050	0.00012303818858	0.153846153846	SUMO1 UBE2I	PIAS1-SUMO1-UBC9 complex
CORUM:1554	0.00012303818858	0.153846153846	RANBP1 RAN	RANBP1-RAN-KPNB1 complex
WP:WP4657	0.00016438514744	0.307692307692	RANBP1 RAN RANGAP1 RCC1	22q11 2 copy number variation syndrome
REAC:R-HSA-9824446	0.00021035873297	0.538461538462	RAN RCC1 UBE2I RANBP1 B2M SUMO1 RANGAP1	Viral Infection Pathways
REAC:R-HSA-162906	0.000240741106702	0.384615384615	RANBP1 RCC1 RAN RANGAP1 B2M	HIV Infection
REAC:R-HSA-68882	0.000251704798352	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Mitotic Anaphase
REAC:R-HSA-2555396	0.000257332832632	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Mitotic Metaphase and Anaphase
HPA:0471411	0.000329831308143	0.538461538462	SUMO2 RANGAP1 DLGAP5 RANBP1 B2M SUMO1 NUSAP1	skin 2; cells in spinous layer[>=Low]
HPA:0471391	0.000651840924926	0.538461538462	SUMO2 RANGAP1 DLGAP5 RANBP1 B2M SUMO1 NUSAP1	skin 2; cells in basal layer[>=Low]
REAC:R-HSA-4085377	0.000734078614392	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of SUMOylation proteins
REAC:R-HSA-5663205	0.000843431952111	0.538461538462	RAN RCC1 UBE2I RANBP1 B2M SUMO1 RANGAP1	Infectious disease
GO:0140014	0.00100290202274	0.461538461538	RAN RCC1 DLGAP5 UBE2I RANBP1 NUSAP1	mitotic nuclear division
REAC:R-HSA-162599	0.00109728954546	0.307692307692	RANBP1 RAN RANGAP1 RCC1	Late Phase of HIV Life Cycle
REAC:R-HSA-3899300	0.00124468307427	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of transcription cofactors
GO:0006913	0.0015085099613	0.461538461538	RANGAP1 NUTF2 UBE2I SUMO1 RGPD2 RAN	nucleocytoplasmic transport
GO:0051169	0.0015085099613	0.461538461538	RANGAP1 NUTF2 UBE2I SUMO1 RGPD2 RAN	nuclear transport
REAC:R-HSA-162587	0.00155899139448	0.307692307692	RANBP1 RAN RANGAP1 RCC1	HIV Life Cycle
REAC:R-HSA-5696395	0.00169033021722	0.230769230769	SUMO2 UBE2I SUMO1	Formation of Incision Complex in GG-NER
REAC:R-HSA-4570464	0.00181617156469	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of RNA binding proteins
REAC:R-HSA-3065676	0.00199260676058	0.153846153846	SUMO2 SUMO1	SUMO is conjugated to E1 (UBA2:SAE1)
REAC:R-HSA-3108232	0.00238102142823	0.307692307692	SUMO2 UBE2I RANGAP1 SUMO1	SUMO E3 ligases SUMOylate target proteins
REAC:R-HSA-2990846	0.0026935333162	0.307692307692	SUMO2 UBE2I RANGAP1 SUMO1	SUMOylation
REAC:R-HSA-3065679	0.00298741024895	0.153846153846	SUMO2 SUMO1	SUMO is proteolytically processed
HPA:0030432	0.00304523503007	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	appendix; germinal center cells[>=Medium]
REAC:R-HSA-68886	0.00374376890678	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	M Phase
WP:WP138	0.00546191810542	0.230769230769	SUMO1 UBE2I RAN	Androgen receptor signaling pathway
HPA:0030442	0.00570376744523	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	appendix; non-germinal center cells[>=Medium]
GO:0016925	0.00625701956595	0.307692307692	SUMO2 UBE2I RANGAP1 SUMO1	protein sumoylation
HPA:0461391	0.00626857633823	0.461538461538	SUMO2 RANGAP1 DLGAP5 B2M SUMO1 NUSAP1	skin 1; cells in basal layer[>=Low]
REAC:R-HSA-4551638	0.00665516605301	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of chromatin organization proteins
REAC:R-HSA-8866904	0.00715899645867	0.153846153846	SUMO1 UBE2I	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
REAC:R-HSA-9683610	0.00715899645867	0.153846153846	SUMO1 UBE2I	Maturation of nucleoprotein
GO:0000280	0.00722163095179	0.461538461538	RAN RCC1 DLGAP5 UBE2I RANBP1 NUSAP1	nuclear division
HPA:0030431	0.00765599524416	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	appendix; germinal center cells[>=Low]
REAC:R-HSA-3108214	0.00829107391439	0.230769230769	SUMO2 UBE2I SUMO1	SUMOylation of DNA damage response and repair proteins
REAC:R-HSA-196791	0.00894425512963	0.153846153846	SUMO2 UBE2I	Vitamin D (calciferol) metabolism
REAC:R-HSA-4755510	0.00894425512963	0.153846153846	SUMO1 UBE2I	SUMOylation of immune response proteins
GO:0031967	0.0117901827978	0.615384615385	RAN NUTF2 UBE2I RANBP1 SUMO1 NEMP1 RGPD2 RANGAP1	organelle envelope
GO:0031975	0.0117901827978	0.615384615385	RAN NUTF2 UBE2I RANBP1 SUMO1 NEMP1 RGPD2 RANGAP1	envelope
HPA:0460202	0.0121687148622	0.384615384615	SUMO2 SUMO1 DLGAP5 RANGAP1 B2M	skin 1; endothelial cells[>=Medium]
HPA:0461412	0.012272203191	0.384615384615	SUMO2 SUMO1 B2M RANGAP1 NUSAP1	skin 1; cells in spinous layer[>=Medium]
REAC:R-HSA-5696399	0.013246545693	0.230769230769	SUMO2 UBE2I SUMO1	Global Genome Nucleotide Excision Repair (GG-NER)
HPA:0030441	0.0142573857875	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	appendix; non-germinal center cells[>=Low]
GO:0048285	0.014388612138	0.461538461538	RAN RCC1 DLGAP5 UBE2I RANBP1 NUSAP1	organelle fission
REAC:R-HSA-9694631	0.0154800492167	0.153846153846	SUMO1 UBE2I	Maturation of nucleoprotein
REAC:R-HSA-69278	0.0163886993661	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Cell Cycle, Mitotic
REAC:R-HSA-4655427	0.0208176207539	0.153846153846	SUMO1 UBE2I	SUMOylation of DNA methylation proteins
HPA:0471412	0.0230457136829	0.384615384615	SUMO2 SUMO1 B2M RANGAP1 NUSAP1	skin 2; cells in spinous layer[>=Medium]
HPA:0401292	0.02600617377	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	rectum; endocrine cells[>=Medium]
REAC:R-HSA-5696398	0.0290572468095	0.230769230769	SUMO2 UBE2I SUMO1	Nucleotide Excision Repair
HPA:0031291	0.0290727693362	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	appendix; endocrine cells[>=Low]
HPA:0310432	0.0293181675688	0.692307692308	SUMO2 RANGAP1 RCC1 UBE2I DLGAP5 RANBP1 B2M SUMO1 NUSAP1	lymph node; germinal center cells[>=Medium]
REAC:R-HSA-1643685	0.029745142168	0.538461538462	RAN RCC1 UBE2I RANBP1 B2M SUMO1 RANGAP1	Disease
HPA:0461461	0.0312616678235	0.384615384615	SUMO2 SUMO1 B2M RANGAP1 NUSAP1	skin 1; langerhans cells[>=Low]
KEGG:05166	0.0362527519559	0.230769230769	RANBP1 RAN B2M	Human T-cell leukemia virus 1 infection
HPA:0401291	0.0374953567356	0.307692307692	RANBP1 NUSAP1 DLGAP5 B2M	rectum; endocrine cells[>=Low]
HPA:0471392	0.0379643835207	0.384615384615	RANBP1 SUMO1 B2M RANGAP1 SUMO2	skin 2; cells in basal layer[>=Medium]
HPA:0461411	0.041040458477	0.384615384615	SUMO2 SUMO1 B2M RANGAP1 NUSAP1	skin 1; cells in spinous layer[>=Low]
REAC:R-HSA-8957322	0.04171948341	0.230769230769	SUMO2 UBE2I RAN	Metabolism of steroids
REAC:R-HSA-1640170	0.0437584916562	0.384615384615	RCC1 SUMO1 UBE2I RANGAP1 RAN	Cell Cycle
GO:0034504	0.0450499593655	0.384615384615	RGPD2 SUMO1 RAN RANGAP1 NUTF2	protein localization to nucleus
HPA:0471461	0.0460098554785	0.384615384615	SUMO2 SUMO1 B2M RANGAP1 NUSAP1	skin 2; langerhans cells[>=Low]
CORUM:680	0.0499717467432	0.0769230769231	RANBP1	RANBMP-CD39 complex
CORUM:7567	0.0499717467432	0.0769230769231	SUMO1	SUMO1-SYT7 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
RAN	RANGAP1	1.0	0.242
UBE2I	SUMO1	1.0	0.234
UBE2I	RCC1	1.0	0.07
UBE2I	RANGAP1	1.0	0.202
RCC1	RANGAP1	1.0	0.254
RANGAP1	RGPD5	1.0	0.14
RANBP1	RCC1	1.0	0.136
RAN	RCC1	1.0	0.16
RCC1	SUMO1	1.0	0.086
RAN	RGPD5	1.0	0.142130434783
RAN	RANBP1	0.999	0.398
UBE2I	NEMP1	0.999	0.11
SUMO2	UBE2I	0.999	0.436
RAN	DLGAP5	0.999	0.213514285714
RAN	NEMP1	0.999	0.09
RCC1	RGPD5	0.999	0.068
RCC1	NEMP1	0.999	0.138
SUMO2	RCC1	0.999	0.161
NUSAP1	RCC1	0.998	0.212
RGPD5	NEMP1	0.998	0.086
RANGAP1	NEMP1	0.998	0.11
UBE2I	RGPD5	0.998	0.114
RANGAP1	SUMO1	0.998	0.454
RAN	SUMO1	0.998	0.416
RGPD5	SUMO1	0.997	0.104
SUMO1	NEMP1	0.996	0.062
RGPD1	RAN	0.996
DLGAP5	RCC1	0.995	0.096
RAN	RGPD2	0.995	0.214
RAN	NUSAP1	0.995	0.282
RGPD2	NEMP1	0.995	0.076
RGPD1	RCC1	0.995
RAN	UBE2I	0.994	0.45
SUMO2	SUMO1	0.993	0.278
B2M	NEMP1	0.992	0.056
B2M	RANGAP1	0.991	0.088
RAN	B2M	0.99	0.066
RGPD2	RANGAP1	0.99	0.184
RAN	NUTF2	0.986	0.228
SUMO2	RAN	0.98	0.49
B2M	RCC1	0.976	0.154
B2M	SUMO1	0.975	0.044
B2M	UBE2I	0.965	0.05
NUSAP1	RANGAP1	0.96	0.254
DLGAP5	SUMO1	0.959	0.082
RGPD2	UBE2I	0.955	0.118
RGPD2	RCC1	0.955	0.14
NUSAP1	NEMP1	0.955	0.066
RGPD1	NUSAP1	0.955
RANBP1	RANGAP1	0.949	0.258
RGPD1	RANGAP1	0.948
DLGAP5	RANGAP1	0.945	0.154
RGPD2	SUMO1	0.931	0.122
B2M	RGPD2	0.916	0.128
RGPD1	UBE2I	0.906
NUSAP1	SUMO1	0.901	0.094
SUMO2	NEMP1	0.878	0.2674
RGPD1	SUMO1	0.867
SUMO2	RANGAP1	0.851	0.45
DLGAP5	RGPD5	0.838	0.06
DLGAP5	UBE2I	0.837	0.142
DLGAP5	RANBP1	0.825	0.118
RANBP1	SUMO1	0.818	0.112333333333
B2M	RGPD5	0.8	0.068
NUSAP1	UBE2I	0.761	0.164
DLGAP5	NUSAP1	0.749	0.168
RGPD1	RGPD5	0.742
RANBP1	RGPD5	0.731	0.07
SUMO2	RGPD5	0.632	0.1
RANBP1	NEMP1	0.52	0.05
DLGAP5	B2M	0.486	0.074
RANBP1	UBE2I	0.456	0.168
RANBP1	NUSAP1	0.434	0.17
NUSAP1	B2M	0.375	0.074
RGPD2	RGPD5	0.36	0.098
RGPD1	DLGAP5	0.329
DLGAP5	NEMP1	0.306	0.06
RGPD2	NUTF2	0.266	0.096
NUTF2	RCC1	0.249	0.078
DLGAP5	RGPD2	0.227	0.05
NUSAP1	RGPD2	0.202	0.136
RGPD1	NEMP1	0.193
RGPD1	RANBP1	0.163
NUSAP1	RGPD5	0.162	0.088
RANBP1	RGPD2	0.135	0.186
DLGAP5	NUTF2	0.128	0.092
SUMO2	RGPD2	0.114	0.1645
SUMO2	NUSAP1	0.099	0.3
NUTF2	RGPD5	0.074	0.092
SUMO2	RANBP1	0.072	0.276
RGPD1	RGPD2	0.055
RGPD1	NUTF2	0.034
NUTF2	SUMO1	0.028	0.1
NUTF2	RANGAP1	0.028	0.086
SUMO2	NUTF2	0.018	0.236
NUTF2	UBE2I	0.017	0.296
NUSAP1	NUTF2	0.014	0.146
B2M	NUTF2	0.013	0.06
SUMO2	DLGAP5	0.013	0.244
RANBP1	NUTF2	0.013	0.182
SUMO2	RGPD1	0.007
SUMO2	B2M	0.004	0.128
NUTF2	NEMP1	0.003	0.056
RANBP1	B2M	0.003	0.216





Related Complexes

Genename	Complexes
RGPD5	huMAP3_05030.1 huMAP3_05712.1 huMAP3_07331.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
UBE2I	huMAP3_02057.1 huMAP3_02554.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07649.1 huMAP3_08641.1 huMAP3_10000.1 huMAP3_12581.1
RGPD1	huMAP3_01999.1 huMAP3_02813.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1
RAN	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_15098.1
NEMP1	huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
RANBP1	huMAP3_01999.1 huMAP3_03516.1 huMAP3_07032.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
DLGAP5	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_14619.1
B2M	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08363.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_13569.1
NUSAP1	huMAP3_01999.1 huMAP3_02813.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1
RGPD2	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_15098.1
NUTF2	huMAP3_01999.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_14100.1 huMAP3_15098.1
RCC1	huMAP3_02264.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1
SUMO2	huMAP3_00864.1 huMAP3_01999.1 huMAP3_02554.1 huMAP3_05860.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07649.1 huMAP3_07958.1 huMAP3_08641.1 huMAP3_10000.1 huMAP3_12375.1 huMAP3_12581.1
SUMO1	huMAP3_05712.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
RANGAP1	huMAP3_02264.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1