hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07382.1
Complex Portal: CPX-21779
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | 5 | UniProt NCBI |
| DYNLT1 | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | 5 | UniProt NCBI |
| DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) | 5 | UniProt NCBI |
| PCBP4 | Poly(rC)-binding protein 4 (Alpha-CP4) | 4 | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | 5 | UniProt NCBI |
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | 5 | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | 5 | UniProt NCBI |
| DYNLRB1 | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | 5 | UniProt NCBI |
| DYNLT3 | Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 3.53394119516e-20 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 1.77571812421e-18 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | cytoplasmic dynein complex |
| GO:0030286 | 1.2106899365e-16 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | dynein complex |
| KEGG:04814 | 8.63455014077e-14 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | Motor proteins |
| KEGG:05132 | 1.20723721775e-12 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | Salmonella infection |
| GO:0005875 | 8.93117431221e-12 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | microtubule associated complex |
| KEGG:04962 | 7.48838695503e-10 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 1.35146253623e-09 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Vasopressin regulated water reabsorption |
| REAC:R-HSA-9646399 | 3.99654025459e-09 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Aggrephagy |
| GO:0007018 | 5.5861176227e-09 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | microtubule-based movement |
| REAC:R-HSA-6811436 | 1.12761199355e-08 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 1.3825436456e-08 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| CORUM:6038 | 5.24129669272e-08 | 0.333333333333 | DYNC1I1 DYNC1LI1 DYNC1H1 | Dynein complex |
| WP:WP4352 | 5.88768716039e-08 | 0.666666666667 | DYNC1I2 DYNLRB1 DYNLT3 DYNC1LI1 DYNLT1 DYNC1H1 | Ciliary landscape |
| REAC:R-HSA-9663891 | 9.1331069582e-08 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Selective autophagy |
| CORUM:6039 | 1.30992062401e-07 | 0.333333333333 | DYNC1I1 DYNC1LI1 DYNC1H1 | Dynein-dynactin complex |
| REAC:R-HSA-141444 | 2.59217745739e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 2.59217745739e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 3.21895987245e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | COPI-mediated anterograde transport |
| KEGG:04145 | 3.44674157584e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Phagosome |
| REAC:R-HSA-69618 | 5.85413794188e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 7.36321241731e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-69620 | 8.70379876009e-07 | 0.666666666667 | DYNC1I2 DYNC1I1 DYNC1LI1 DYNC1LI2 PCBP4 DYNC1H1 | Cell Cycle Checkpoints |
| REAC:R-HSA-2132295 | 8.78122333528e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 9.98125265684e-07 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 1.04090893218e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-1632852 | 1.27732061414e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Macroautophagy |
| REAC:R-HSA-8856688 | 1.27732061414e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 1.61555801825e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | RHO GTPases Activate Formins |
| GO:0045504 | 1.6375274005e-06 | 0.444444444444 | DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | dynein heavy chain binding |
| REAC:R-HSA-9612973 | 2.25319041775e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Autophagy |
| REAC:R-HSA-9609646 | 2.33488700563e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | HCMV Infection |
| REAC:R-HSA-199977 | 2.41892837707e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | ER to Golgi Anterograde Transport |
| CORUM:6236 | 2.87561751823e-06 | 0.333333333333 | DYNLT3 DYNLT1 DYNLRB1 | Dynein-2 complex, cytoplasmic |
| REAC:R-HSA-948021 | 6.12222630318e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 8.5867999114e-06 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Separation of Sister Chromatids |
| GO:0007017 | 1.07256914784e-05 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | microtubule-based process |
| REAC:R-HSA-6811442 | 1.09080422802e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 1.14859676503e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 2.24673473266e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 2.29749972133e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-446203 | 7.36402959736e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 9.20482128285e-05 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | RHO GTPase Effectors |
| REAC:R-HSA-1640170 | 0.000130629538989 | 0.666666666667 | DYNC1I2 DYNC1I1 DYNC1LI1 DYNC1LI2 PCBP4 DYNC1H1 | Cell Cycle |
| GO:0015630 | 0.000221054905678 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | microtubule cytoskeleton |
| REAC:R-HSA-68886 | 0.000347067936071 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | M Phase |
| WP:WP4906 | 0.000423991302669 | 0.333333333333 | DYNLT3 DYNLT1 DYNLRB1 | 3q29 copy number variation syndrome |
| GO:0003777 | 0.000885827799668 | 0.444444444444 | DYNC1I2 DYNC1H1 DYNLRB1 DYNC1I1 | microtubule motor activity |
| REAC:R-HSA-69278 | 0.00156916538003 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Cell Cycle, Mitotic |
| REAC:R-HSA-199991 | 0.00238452036519 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Membrane Trafficking |
| GO:0045505 | 0.00292902387419 | 0.333333333333 | DYNLT3 DYNLT1 DYNLRB1 | dynein intermediate chain binding |
| REAC:R-HSA-5653656 | 0.00310840446846 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Vesicle-mediated transport |
| REAC:R-HSA-194315 | 0.00378608973096 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00421340951126 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1280218 | 0.00488874967394 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Adaptive Immune System |
| GO:0005856 | 0.00564626210456 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | cytoskeleton |
| GO:1902494 | 0.00573478933095 | 0.888888888889 | DYNC1I2 DYNLRB1 DYNC1I1 DYNLT3 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | catalytic complex |
| REAC:R-HSA-9824446 | 0.00644900522555 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Viral Infection Pathways |
| REAC:R-HSA-2262752 | 0.00738791222428 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0077407268337 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Cellular responses to stimuli |
| GO:0003774 | 0.00790837187115 | 0.444444444444 | DYNC1I2 DYNC1H1 DYNLRB1 DYNC1I1 | cytoskeletal motor activity |
| REAC:R-HSA-5663205 | 0.0174507834687 | 0.555555555556 | DYNC1LI1 DYNC1I2 DYNC1H1 DYNC1LI2 DYNC1I1 | Infectious disease |
| REAC:R-HSA-168256 | 0.0342353908338 | 0.666666666667 | DYNC1I2 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNLT1 DYNC1H1 | Immune System |
| REAC:R-HSA-5617833 | 0.0400093234819 | 0.333333333333 | DYNC1I2 DYNLRB1 DYNC1H1 | Cilium Assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I2 | DYNC1LI2 | 1.0 | 0.586 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1LI1 | 1.0 | 0.63 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1LI1 | DYNLT1 | 1.0 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1LI2 | DYNLT1 | 1.0 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM Malo gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNLT1 | 1.0 | 0.71 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DYNC1I2 | DYNC1I1 | 0.999 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1LI2 | DYNC1LI1 | 0.999 | 0.296 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| DYNC1LI2 | DYNC1H1 | 0.999 | 0.488 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNLT1 | 0.999 | 0.502 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNC1LI1 | 0.999 | 0.618 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I1 | DYNLRB1 | 0.999 | 0.262 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DYNC1I1 | DYNC1LI2 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I1 | DYNC1LI1 | 0.999 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I2 | DYNC1H1 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| DYNC1I1 | DYNLT3 | 0.999 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1LI1 | DYNLT3 | 0.998 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1LI1 | DYNLRB1 | 0.998 | 0.528 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I1 | DYNC1H1 | 0.998 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I2 | DYNLT3 | 0.997 | 0.434 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1I2 | DYNLRB1 | 0.991 | 0.856 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| DYNLT3 | DYNLRB1 | 0.989 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| DYNC1I1 | DYNLT1 | 0.987 | 0.296 | bioplex3_HEK293 bioplex3_WMM gupta () bioplex3_HCT116 gupta_WMM | |
| DYNC1LI2 | DYNLT3 | 0.983 | 0.032 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PCBP4 | DYNC1LI1 | 0.978 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1H1 | DYNLT3 | 0.972 | 0.336 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| DYNC1LI2 | DYNLRB1 | 0.972 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM | |
| DYNLT1 | DYNLRB1 | 0.972 | 0.386 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| PCBP4 | DYNC1I2 | 0.969 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNLT1 | 0.952 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1H1 | 0.918 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNLRB1 | 0.889 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1LI2 | 0.876 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNLT3 | DYNLT1 | 0.853 | 0.046 |
mutually_exclusive (Q8WW35)
structurally_consistent (dimer) |
bioplex3_WMM boldt boldt_WMM WMM_only |
| DYNC1H1 | DYNLRB1 | 0.732 | 0.48 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM fraction boldt_WMM |
Related Complexes