hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07383.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTPRF | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | 5 | UniProt NCBI |
| TMEM204 | Transmembrane protein 204 (Claudin-like protein 24) | 4 | UniProt NCBI |
| SLC8A1 | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | 5 | UniProt NCBI |
| KCNK18 | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| ACVR1B | Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) | 5 | UniProt NCBI |
| FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5576891 | 0.000689296551176 | 0.5 | SLC8A1 KCNK18 FKBP1B | Cardiac conduction |
| REAC:R-HSA-397014 | 0.00380890170895 | 0.5 | SLC8A1 KCNK18 FKBP1B | Muscle contraction |
| REAC:R-HSA-5578775 | 0.0210220699274 | 0.333333333333 | SLC8A1 FKBP1B | Ion homeostasis |
| KEGG:04350 | 0.0267786555833 | 0.333333333333 | ACVR1 ACVR1B | TGF-beta signaling pathway |
| GO:0016361 | 0.042122686785 | 0.333333333333 | ACVR1 ACVR1B | activin receptor activity, type I |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ACVR1 | ACVR1B | 0.997 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACVR1 | PTPRF | 0.994 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACVR1 | TMEM204 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | FKBP1B | 0.989 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACVR1 | SLC8A1 | 0.989 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACVR1 | KCNK18 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ACVR1B | PTPRF | 0.963 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| SLC8A1 | FKBP1B | 0.557 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC8A1 | ACVR1B | 0.109 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| ACVR1B | FKBP1B | 0.109 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| KCNK18 | ACVR1B | 0.094 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KCNK18 | PTPRF | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FKBP1B | PTPRF | 0.053 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC8A1 | PTPRF | 0.053 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes