hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07385.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDLRAD3 | Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) | 5 | UniProt NCBI |
| WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) | 5 | UniProt NCBI |
| TMEM255A | Transmembrane protein 255A (Protein FAM70A) | 3 | UniProt NCBI |
| ENTREP1 | Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) | 5 | UniProt NCBI |
| ITCH | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1253288 | 0.000425287580531 | 0.4 | WWP1 ITCH | Downregulation of ERBB4 signaling |
| REAC:R-HSA-1236394 | 0.0136499247655 | 0.4 | WWP1 ITCH | Signaling by ERBB4 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WWP1 | ITCH | 0.982 | 0.152 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM treiber_WMM WMM_only |
| WWP1 | ENTREP1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ENTREP1 | ITCH | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WWP1 | LDLRAD3 | 0.969 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TMEM255A | WWP1 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TMEM255A | ITCH | 0.951 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LDLRAD3 | ITCH | 0.06 | bioplex3_WMM WMM_only |
Related Complexes