hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07390.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | 5 | UniProt NCBI |
| DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5358493 | 3.58839967947e-05 | 1.0 | DPH2 DPH1 | Synthesis of diphthamide-EEF2 |
| HP:0012712 | 7.17679935894e-05 | 1.0 | DPH2 DPH1 | Mild hearing impairment |
| HP:0007291 | 0.000410102820511 | 1.0 | DPH2 DPH1 | Posterior fossa cyst |
| GO:0090560 | 0.000468200720083 | 1.0 | DPH2 DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase activity |
| HP:0004442 | 0.000649329465809 | 1.0 | DPH2 DPH1 | Sagittal craniosynostosis |
| HP:0001970 | 0.000717679935894 | 1.0 | DPH2 DPH1 | Tubulointerstitial nephritis |
| HP:0000805 | 0.000864633446577 | 1.0 | DPH2 DPH1 | Enuresis |
| REAC:R-HSA-163841 | 0.00113803532692 | 1.0 | DPH2 DPH1 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| HP:0030799 | 0.00227607065384 | 1.0 | DPH2 DPH1 | Scaphocephaly |
| HP:0000243 | 0.00240251902349 | 1.0 | DPH2 DPH1 | Trigonocephaly |
| HP:0004482 | 0.00353713682691 | 1.0 | DPH2 DPH1 | Relative macrocephaly |
| HP:0001969 | 0.00401900764101 | 1.0 | DPH2 DPH1 | Abnormal tubulointerstitial morphology |
| HP:0001650 | 0.00418646629272 | 1.0 | DPH2 DPH1 | Aortic valve stenosis |
| HP:0032581 | 0.00489047613459 | 1.0 | DPH2 DPH1 | Abnormal renal insterstitial morphology |
| HP:0007598 | 0.00507502240382 | 1.0 | DPH2 DPH1 | Bilateral single transverse palmar creases |
| GO:0017183 | 0.00702301080125 | 1.0 | DPH2 DPH1 | protein histidyl modification to diphthamide |
| HP:0001800 | 0.00755614446791 | 1.0 | DPH2 DPH1 | Hypoplastic toenails |
| GO:0018202 | 0.00983221512175 | 1.0 | DPH2 DPH1 | peptidyl-histidine modification |
| HP:0000091 | 0.011629832485 | 1.0 | DPH2 DPH1 | Abnormal renal tubule morphology |
| HP:0200055 | 0.0136871816346 | 1.0 | DPH2 DPH1 | Small hand |
| HP:0010624 | 0.0159119894358 | 1.0 | DPH2 DPH1 | Aplastic/hypoplastic toenail |
| HP:0000687 | 0.0216260887349 | 1.0 | DPH2 DPH1 | Widely spaced teeth |
| HP:0002209 | 0.0260620342435 | 1.0 | DPH2 DPH1 | Sparse scalp hair |
| HP:0001305 | 0.026485807158 | 1.0 | DPH2 DPH1 | Dandy-Walker malformation |
| HP:0045075 | 0.0282150740512 | 1.0 | DPH2 DPH1 | Sparse eyebrow |
| HP:0010535 | 0.0295479082178 | 1.0 | DPH2 DPH1 | Sleep apnea |
| HP:5200283 | 0.0299990213204 | 1.0 | DPH2 DPH1 | Sleep-related breathing disorders |
| HP:0008388 | 0.0327774679293 | 1.0 | DPH2 DPH1 | Abnormal toenail morphology |
| HP:0010950 | 0.0351868219998 | 1.0 | DPH2 DPH1 | Abnormal fourth ventricle morphology |
| HP:0002198 | 0.0351868219998 | 1.0 | DPH2 DPH1 | Dilated fourth ventricle |
| GO:0051539 | 0.0365196561665 | 1.0 | DPH2 DPH1 | 4 iron, 4 sulfur cluster binding |
| HP:0031652 | 0.0371758206793 | 1.0 | DPH2 DPH1 | Abnormal aortic valve physiology |
| HP:0002350 | 0.0376816141579 | 1.0 | DPH2 DPH1 | Cerebellar cyst |
| HP:0001792 | 0.0381908251601 | 1.0 | DPH2 DPH1 | Small nail |
| HP:0001363 | 0.0456786191579 | 1.0 | DPH2 DPH1 | Craniosynostosis |
| HP:0005445 | 0.0490927251387 | 1.0 | DPH2 DPH1 | Enlarged posterior fossa |
| HP:0012413 | 0.0499436884913 | 0.5 | DPH2 | Notched primary central incisor |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DPH2 | DPH1 | 0.99 | 0.382 | bioplex_WMM Guru bioplex3_WMM fraction |
Related Complexes