hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07391.1

Complex Portal: CPX-22085

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PDAP1	28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1)	4	UniProt NCBI
RTRAF	RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)	5	UniProt NCBI
YTHDF3	YTH domain-containing family protein 3 (DF3)	5	UniProt NCBI
DEK	Protein DEK	5	UniProt NCBI
NEMF	Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)	5	UniProt NCBI
FAM98B	Protein FAM98B	5	UniProt NCBI
RTCB	RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	5	UniProt NCBI
DDX1	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6301	1.68018318789e-11	0.5	RTCB DDX1 RTRAF FAM98B	tRNA Splicing Ligase Complex
GO:0072669	1.28818969855e-07	0.5	RTCB DDX1 RTRAF FAM98B	tRNA-splicing ligase complex
GO:0006388	6.06890408176e-07	0.5	RTCB DDX1 RTRAF FAM98B	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	9.10136169988e-07	0.5	RTCB DDX1 RTRAF FAM98B	RNA splicing, via endonucleolytic cleavage and ligation
REAC:R-HSA-6784531	2.64339217392e-06	0.5	RTCB DDX1 RTRAF FAM98B	tRNA processing in the nucleus
REAC:R-HSA-72306	2.88954874757e-05	0.5	RTCB DDX1 RTRAF FAM98B	tRNA processing
GO:0003723	0.000348124406106	1.0	RTCB DDX1 FAM98B YTHDF3 PDAP1 DEK NEMF RTRAF	RNA binding
HPA:0100122	0.00248671655517	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	cerebral cortex; glial cells[>=Medium]
HPA:0490692	0.00688674603574	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	smooth muscle; smooth muscle cells[>=Medium]
HPA:0340462	0.0109830778194	0.75	RTCB DDX1 FAM98B PDAP1 DEK RTRAF	ovary; ovarian stroma cells[>=Medium]
GO:0008033	0.011578905434	0.5	RTCB DDX1 RTRAF FAM98B	tRNA processing
HPA:0130242	0.0134729587429	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	colon; peripheral nerve/ganglion[>=Medium]
HPA:0440342	0.0241638804332	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	skeletal muscle; myocytes[>=Medium]
HPA:0050092	0.0271872872672	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	breast; myoepithelial cells[>=Medium]
HPA:0291161	0.0381002852614	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	liver; cholangiocytes[>=Low]
HPA:0340461	0.0402241829976	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	ovary; ovarian stroma cells[>=Low]
HPA:0090163	0.0403815411115	0.625	PDAP1 DDX1 RTRAF FAM98B NEMF	cerebellum; Purkinje cells[High]
HPA:0630052	0.0408273538891	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	cervix; glandular cells[>=Medium]
HPA:0351183	0.0437717975659	0.5	PDAP1 DDX1 RTRAF RTCB	pancreas; pancreatic endocrine cells[High]
HPA:0160251	0.0461011612967	0.875	RTCB DDX1 FAM98B PDAP1 DEK NEMF RTRAF	endometrium 1; cells in endometrial stroma[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
DDX1	RTCB	1.0	0.978	structurally_consistent (dimer)	hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
RTRAF	DDX1	1.0	0.97	mutually_exclusive (Q9Y3I0)	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
DDX1	FAM98B	1.0	0.776		youn () bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM
RTRAF	RTCB	0.996	0.92	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RTRAF	YTHDF3	0.978	0.116		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
RTRAF	NEMF	0.978	0.136		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDAP1	RTRAF	0.977	0.12		hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only
DEK	RTRAF	0.976	0.13		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
NEMF	DDX1	0.974	0.138		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NEMF	RTCB	0.973	0.162		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
DEK	RTCB	0.97	0.118		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
PDAP1	NEMF	0.964	0.098		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RTRAF	FAM98B	0.953	0.61	structurally_consistent (dimer)	bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction
NEMF	YTHDF3	0.951	0.274		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
DEK	NEMF	0.883	0.062		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDAP1	YTHDF3	0.873	0.108		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
YTHDF3	DDX1	0.858	0.182		hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
YTHDF3	RTCB	0.852	0.18		hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
PDAP1	DEK	0.679	0.156		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DEK	DDX1	0.673	0.208		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
FAM98B	RTCB	0.525	0.686		bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
PDAP1	RTCB	0.498	0.08		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
PDAP1	DDX1	0.268	0.074		hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
DEK	YTHDF3	0.203	0.042		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
NEMF	FAM98B	0.184	0.042		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
DEK	FAM98B	0.012	0.1		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PDAP1	FAM98B	0.005	0.068		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
YTHDF3	FAM98B	0.004	0.046		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
PDAP1	huMAP3_00117.1 huMAP3_02515.1 huMAP3_04065.1 huMAP3_04560.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
RTRAF	huMAP3_00117.1 huMAP3_02515.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
YTHDF3	huMAP3_00405.1 huMAP3_00843.1 huMAP3_02678.1 huMAP3_04763.1 huMAP3_05880.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07881.1 huMAP3_10307.1 huMAP3_10523.1 huMAP3_10590.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
DEK	huMAP3_00117.1 huMAP3_02515.1 huMAP3_04351.1 huMAP3_06521.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09423.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
NEMF	huMAP3_00371.1 huMAP3_02373.1 huMAP3_06629.1 huMAP3_07298.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07574.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_08872.1 huMAP3_09457.1 huMAP3_09507.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10359.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11021.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
FAM98B	huMAP3_00810.1 huMAP3_02376.1 huMAP3_02778.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_10307.1 huMAP3_10616.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
RTCB	huMAP3_02515.1 huMAP3_04351.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09423.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
DDX1	huMAP3_00810.1 huMAP3_00865.1 huMAP3_02778.1 huMAP3_06830.1 huMAP3_06848.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07781.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07391.1

Complex Portal: CPX-22085