hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07401.1
Complex Portal: CPX-10815
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CSTB | Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| VWA3B | von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B) | 5 | UniProt NCBI |
| AIRE | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | 5 | UniProt NCBI |
| CTSL | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04210 | 0.0319348346673 | 0.4 | CTSH CTSL | Apoptosis |
| KEGG:04142 | 0.0335445792486 | 0.4 | CTSH CTSL | Lysosome |
| CORUM:1985 | 0.0498708842806 | 0.2 | AIRE | AIRE homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AIRE | CTSH | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSL | CTSH | 0.969 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CTSH | VWA3B | 0.966 | 0.05 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CSTB | CTSH | 0.951 | 0.134 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CTSL | CSTB | 0.355 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM |
| CSTB | VWA3B | 0.005 | 0.04 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes