hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07402.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KICS2 | KICSTOR subunit 2 (KICSTOR complex protein C12orf66) | 5 | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | 5 | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6754 | 9.35474852325e-10 | 1.0 | SZT2 KICS2 ITFG2 | KICSTOR complex |
| GO:0140007 | 3.84480164306e-07 | 1.0 | SZT2 KICS2 ITFG2 | KICSTOR complex |
| REAC:R-HSA-9639288 | 1.09306217585e-05 | 1.0 | SZT2 KICS2 ITFG2 | Amino acids regulate mTORC1 |
| REAC:R-HSA-9711097 | 0.000273091034762 | 1.0 | SZT2 KICS2 ITFG2 | Cellular response to starvation |
| GO:0042149 | 0.000949666005835 | 1.0 | SZT2 KICS2 ITFG2 | cellular response to glucose starvation |
| GO:1904262 | 0.00110345807156 | 1.0 | SZT2 KICS2 ITFG2 | negative regulation of TORC1 signaling |
| GO:0034198 | 0.00118621742692 | 1.0 | SZT2 KICS2 ITFG2 | cellular response to amino acid starvation |
| GO:1990928 | 0.00136394338287 | 1.0 | SZT2 KICS2 ITFG2 | response to amino acid starvation |
| GO:0032007 | 0.00312476641535 | 1.0 | SZT2 KICS2 ITFG2 | negative regulation of TOR signaling |
| GO:1903432 | 0.00949377645712 | 1.0 | SZT2 KICS2 ITFG2 | regulation of TORC1 signaling |
| GO:0038202 | 0.0109157763448 | 1.0 | SZT2 KICS2 ITFG2 | TORC1 signaling |
| GO:0009267 | 0.0263194935275 | 1.0 | SZT2 KICS2 ITFG2 | cellular response to starvation |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | SZT2 KICS2 ITFG2 | Cellular responses to stress |
| GO:0032006 | 0.0298091316188 | 1.0 | SZT2 KICS2 ITFG2 | regulation of TOR signaling |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | SZT2 KICS2 ITFG2 | Cellular responses to stimuli |
| GO:0042594 | 0.039413061643 | 1.0 | SZT2 KICS2 ITFG2 | response to starvation |
| GO:0031929 | 0.0411908979227 | 1.0 | SZT2 KICS2 ITFG2 | TOR signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SZT2 | ITFG2 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | ITFG2 | 0.999 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | SZT2 | 0.989 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes