hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07405.1
Complex Portal: CPX-14056
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CLTC | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | 5 | UniProt NCBI |
| CLTB | Clathrin light chain B (Lcb) | 5 | UniProt NCBI |
| SEC16A | Protein transport protein Sec16A (SEC16 homolog A) (p250) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-196025 | 0.000374861161166 | 0.666666666667 | CLTB CLTC | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.000449812862905 | 0.666666666667 | CLTB CLTC | Gap junction degradation |
| REAC:R-HSA-5140745 | 0.000531572756485 | 0.666666666667 | CLTB CLTC | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 0.000715513386354 | 0.666666666667 | CLTB CLTC | WNT5A-dependent internalization of FZD4 |
| KEGG:04961 | 0.000823509653423 | 0.666666666667 | CLTB CLTC | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04721 | 0.00134759096089 | 0.666666666667 | CLTB CLTC | Synaptic vesicle cycle |
| KEGG:05100 | 0.00216826178203 | 0.666666666667 | CLTB CLTC | Bacterial invasion of epithelial cells |
| REAC:R-HSA-432720 | 0.00359505378021 | 0.666666666667 | CLTB CLTC | Lysosome Vesicle Biogenesis |
| REAC:R-HSA-190828 | 0.00504394814871 | 0.666666666667 | CLTB CLTC | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00530917647079 | 0.666666666667 | CLTB CLTC | Gap junction trafficking and regulation |
| KEGG:04142 | 0.00569595332742 | 0.666666666667 | CLTB CLTC | Lysosome |
| REAC:R-HSA-3928665 | 0.00643790104829 | 0.666666666667 | CLTB CLTC | EPH-ephrin mediated repulsion of cells |
| WP:WP4549 | 0.0067573392711 | 0.666666666667 | CLTB CLTC | Fragile X syndrome |
| WP:WP4217 | 0.00751610583681 | 0.666666666667 | CLTB CLTC | Ebola virus infection in host |
| WP:WP5381 | 0.0109522066155 | 0.666666666667 | CLTB CLTC | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-199991 | 0.0145539954891 | 1.0 | CLTB CLTC SEC16A | Membrane Trafficking |
| REAC:R-HSA-199992 | 0.0164154902665 | 0.666666666667 | CLTB CLTC | trans-Golgi Network Vesicle Budding |
| REAC:R-HSA-5653656 | 0.017135828319 | 1.0 | CLTB CLTC SEC16A | Vesicle-mediated transport |
| KEGG:04144 | 0.0200670831031 | 0.666666666667 | CLTB CLTC | Endocytosis |
| REAC:R-HSA-2682334 | 0.02256145142 | 0.666666666667 | CLTB CLTC | EPH-Ephrin signaling |
| KEGG:05016 | 0.0275851821163 | 0.666666666667 | CLTB CLTC | Huntington disease |
| REAC:R-HSA-4086400 | 0.0278082114556 | 0.666666666667 | CLTB CLTC | PCP/CE pathway |
| REAC:R-HSA-8856825 | 0.0296783854994 | 0.666666666667 | CLTB CLTC | Cargo recognition for clathrin-mediated endocytosis |
| GO:0030662 | 0.0498541011049 | 1.0 | CLTB CLTC SEC16A | coated vesicle membrane |
| CORUM:6080 | 0.0499402709677 | 0.333333333333 | CLTC | ACAP1-CHC-Glut4 complex |
| CORUM:6691 | 0.0499402709677 | 0.333333333333 | CLTC | CLTC-PI4K2A complex |
| CORUM:7269 | 0.0499402709677 | 0.333333333333 | CLTC | p532-Clathrin-HSP70 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CLTC | CLTB | 0.992 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () fraction boldt_WMM | ||
| CLTB | SEC16A | 0.971 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction | ||
| CLTC | SEC16A | 0.723 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CLTC | huMAP3_07405.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1 |
| CLTB | huMAP3_07405.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 |
| SEC16A | huMAP3_07405.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1 |