hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07416.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 1.86640856459e-09 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 3.91945798564e-08 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | PI5P Regulates TP53 Acetylation |
| GO:1902633 | 9.61200410764e-08 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:0016309 | 9.61200410764e-08 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902635 | 9.61200410764e-08 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| WP:WP4971 | 8.89885541579e-07 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Phosphoinositides metabolism |
| WP:WP5411 | 8.89885541579e-07 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Phosphatidyl inositol phosphate pathway |
| REAC:R-HSA-6804758 | 1.89440469306e-06 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Regulation of TP53 Activity through Acetylation |
| KEGG:00562 | 2.28180619251e-06 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Inositol phosphate metabolism |
| KEGG:04070 | 5.159661118e-06 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Phosphatidylinositol signaling system |
| GO:0016308 | 5.38272230028e-06 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 7.56595371871e-06 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Synthesis of PIPs at the plasma membrane |
| WP:WP51 | 2.6462157373e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Regulation of actin cytoskeleton |
| REAC:R-HSA-1483255 | 2.78281516981e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | PI Metabolism |
| REAC:R-HSA-6811558 | 3.02470171978e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 3.98104946827e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Negative regulation of the PI3K/AKT network |
| KEGG:04810 | 6.3567996622e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Regulation of actin cytoskeleton |
| GO:2000786 | 6.5361627932e-05 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of autophagosome assembly |
| GO:0044090 | 0.000148024863258 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of vacuole organization |
| GO:0052742 | 0.000170228592746 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | phosphatidylinositol kinase activity |
| GO:0046627 | 0.000221076094476 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | negative regulation of insulin receptor signaling pathway |
| GO:1900077 | 0.000249912106799 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | negative regulation of cellular response to insulin stimulus |
| REAC:R-HSA-5633007 | 0.000267736308591 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.000416769032473 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Phospholipid metabolism |
| GO:0001727 | 0.000686297093286 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | lipid kinase activity |
| GO:2000785 | 0.000878441055398 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | regulation of autophagosome assembly |
| REAC:R-HSA-1257604 | 0.000933885521422 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | PIP3 activates AKT signaling |
| GO:0046626 | 0.00102463963787 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | regulation of insulin receptor signaling pathway |
| GO:1900076 | 0.00110345807156 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | regulation of cellular response to insulin stimulus |
| REAC:R-HSA-9006925 | 0.001430872794 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Intracellular signaling by second messengers |
| GO:0046854 | 0.00155858646605 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | phosphatidylinositol phosphate biosynthetic process |
| GO:0044088 | 0.00166249223046 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | regulation of vacuole organization |
| REAC:R-HSA-3700989 | 0.00297633187542 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Transcriptional Regulation by TP53 |
| GO:0016239 | 0.00328922780564 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of macroautophagy |
| GO:1902117 | 0.00381702295119 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of organelle assembly |
| GO:0005776 | 0.00675723888767 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | autophagosome |
| GO:0008286 | 0.00789722257484 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | insulin receptor signaling pathway |
| GO:0000045 | 0.013733631469 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | autophagosome assembly |
| GO:1905037 | 0.0155426106421 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | autophagosome organization |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Metabolism of lipids |
| KEGG:01100 | 0.0189521995452 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | Metabolic pathways |
| GO:0006661 | 0.0190783863531 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | phosphatidylinositol biosynthetic process |
| GO:0046488 | 0.030542143052 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | phosphatidylinositol metabolic process |
| GO:0010508 | 0.030542143052 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | positive regulation of autophagy |
| GO:0032869 | 0.0360123345897 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | cellular response to insulin stimulus |
| GO:0016241 | 0.0376871301854 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | regulation of macroautophagy |
| GO:0061909 | 0.0393180950424 | 0.666666666667 | PIP4K2A PIP4K2B | autophagosome-lysosome fusion |
| GO:0032868 | 0.0449053607901 | 1.0 | PIP4K2B PIP4K2C PIP4K2A | response to insulin |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
Related Complexes