hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07424.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIAM1 | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | 5 | UniProt NCBI |
| YWHAQ | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | 5 | UniProt NCBI |
| FOXO1 | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | 5 | UniProt NCBI |
| FOXO4 | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | 5 | UniProt NCBI |
| DENND4A | C-myc promoter-binding protein (DENN domain-containing protein 4A) | 5 | UniProt NCBI |
| A0A1X9RU27 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9614399 | 7.1764766158e-10 | 0.666666666667 | FOXO4 YWHAQ A0A1X9RU27 FOXO1 | Regulation of localization of FOXO transcription factors |
| WP:WP4542 | 1.34126591933e-08 | 0.666666666667 | FOXO4 YWHAQ A0A1X9RU27 FOXO1 | Leukocyte intrinsic Hippo pathway functions |
| REAC:R-HSA-9614085 | 7.03257303358e-07 | 0.666666666667 | FOXO4 YWHAQ A0A1X9RU27 FOXO1 | FOXO-mediated transcription |
| REAC:R-HSA-198693 | 8.4720413934e-07 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | AKT phosphorylates targets in the nucleus |
| REAC:R-HSA-5674400 | 1.62005905893e-05 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | Constitutive Signaling by AKT1 E17K in Cancer |
| REAC:R-HSA-9615017 | 1.62005905893e-05 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| KEGG:04068 | 0.0004581001419 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | FoxO signaling pathway |
| REAC:R-HSA-2219528 | 0.000491292751059 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-9617629 | 0.00116019984728 | 0.333333333333 | FOXO1 FOXO4 | Regulation of FOXO transcriptional activity by acetylation |
| REAC:R-HSA-9617828 | 0.00309047926945 | 0.333333333333 | FOXO1 FOXO4 | FOXO-mediated transcription of cell cycle genes |
| REAC:R-HSA-9614657 | 0.00309047926945 | 0.333333333333 | FOXO1 FOXO4 | FOXO-mediated transcription of cell death genes |
| KEGG:05131 | 0.00369808394071 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | Shigellosis |
| WP:WP3844 | 0.00436073489596 | 0.333333333333 | FOXO1 FOXO4 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| REAC:R-HSA-1257604 | 0.0136572631243 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | PIP3 activates AKT signaling |
| WP:WP2324 | 0.0176466803728 | 0.333333333333 | FOXO1 FOXO4 | AGE RAGE pathway |
| REAC:R-HSA-9006925 | 0.0208115615403 | 0.5 | FOXO1 A0A1X9RU27 FOXO4 | Intracellular signaling by second messengers |
| WP:WP2261 | 0.0290813206156 | 0.333333333333 | FOXO1 FOXO4 | Glioblastoma signaling pathways |
| REAC:R-HSA-162582 | 0.0495022563739 | 0.833333333333 | FOXO4 TIAM1 A0A1X9RU27 FOXO1 YWHAQ | Signal Transduction |
| CORUM:6242 | 0.0499436884912 | 0.166666666667 | YWHAQ | 14-3-3q-SGK1-tau complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| YWHAQ | FOXO1 | 0.97 | 0.508 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| YWHAQ | TIAM1 | 0.956 | 0.386 | bioplex3_HEK293 bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| YWHAQ | FOXO4 | 0.954 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| YWHAQ | DENND4A | 0.952 | 0.338 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| TIAM1 | DENND4A | 0.534 | 0.155 | bioplex3_WMM boldt boldt_WMM WMM_only |
| TIAM1 | FOXO1 | 0.496 | 0.16 | bioplex3_WMM boldt boldt_WMM WMM_only |
| DENND4A | FOXO1 | 0.454 | 0.076 | bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| FOXO4 | FOXO1 | 0.283 | bioplex3_WMM WMM_only | |
| FOXO4 | DENND4A | 0.238 | bioplex3_WMM WMM_only | |
| FOXO4 | TIAM1 | 0.238 | bioplex3_WMM WMM_only |
Related Complexes