hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07425.1

Complex Portal: CPX-20047

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PDAP1	28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1)	4	UniProt NCBI
RTRAF	RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)	5	UniProt NCBI
DEK	Protein DEK	5	UniProt NCBI
NEMF	Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)	5	UniProt NCBI
CAPRIN1	Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)	5	UniProt NCBI
G3BP1	Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)	5	UniProt NCBI
FAM98A	Protein FAM98A	5	UniProt NCBI
FAM98B	Protein FAM98B	5	UniProt NCBI
RTCB	RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6301	1.30992062401e-07	0.333333333333	FAM98B RTRAF RTCB	tRNA Splicing Ligase Complex
GO:0072669	2.31823352537e-07	0.444444444444	FAM98B RTCB RTRAF FAM98A	tRNA-splicing ligase complex
GO:0006388	1.09198397762e-06	0.444444444444	FAM98B RTCB RTRAF FAM98A	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	1.6375274005e-06	0.444444444444	FAM98B RTCB RTRAF FAM98A	RNA splicing, via endonucleolytic cleavage and ligation
GO:0003723	3.31751333813e-05	1.0	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF FAM98A	RNA binding
REAC:R-HSA-6784531	0.000987938284138	0.333333333333	FAM98B RTRAF RTCB	tRNA processing in the nucleus
REAC:R-HSA-72306	0.00582679710393	0.333333333333	FAM98B RTRAF RTCB	tRNA processing
HPA:0440342	0.00694157986124	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	skeletal muscle; myocytes[>=Medium]
HPA:0050092	0.00794725273271	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	breast; myoepithelial cells[>=Medium]
HPA:0100122	0.0107447143516	0.777777777778	DEK PDAP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	cerebral cortex; glial cells[>=Medium]
HPA:0340461	0.0124593164562	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	ovary; ovarian stroma cells[>=Low]
HPA:0160251	0.0145710452103	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	endometrium 1; cells in endometrial stroma[>=Low]
GO:0003676	0.0151133869702	1.0	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF FAM98A	nucleic acid binding
HPA:0250132	0.0189579807785	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	hippocampus; neuronal cells[>=Medium]
GO:0008033	0.0207177387556	0.444444444444	FAM98B RTCB RTRAF FAM98A	tRNA processing
HPA:0530721	0.0230015041937	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	spleen; cells in white pulp[>=Low]
HPA:0330222	0.0234578036135	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	oral mucosa; squamous epithelial cells[>=Medium]
HPA:0490692	0.0289589517706	0.777777777778	DEK PDAP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	smooth muscle; smooth muscle cells[>=Medium]
HPA:0340462	0.0328979263438	0.666666666667	DEK PDAP1 RTCB CAPRIN1 RTRAF FAM98B	ovary; ovarian stroma cells[>=Medium]
HPA:0510701	0.0344354659669	0.777777777778	DEK PDAP1 G3BP1 CAPRIN1 RTRAF FAM98B NEMF	soft tissue 2; peripheral nerve[>=Low]
HPA:0210052	0.0414605141369	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	fallopian tube; glandular cells[>=Medium]
HPA:0030071	0.0429881181967	0.888888888889	DEK PDAP1 G3BP1 RTCB CAPRIN1 RTRAF FAM98B NEMF	appendix; lymphoid tissue[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RTRAF	FAM98A	0.999	0.178	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
FAM98A	RTCB	0.998	0.25		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
RTRAF	RTCB	0.996	0.92	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RTRAF	G3BP1	0.988	0.198		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM
CAPRIN1	G3BP1	0.988	0.84		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
NEMF	G3BP1	0.98	0.156		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RTRAF	NEMF	0.978	0.136		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDAP1	RTRAF	0.977	0.12		hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only
DEK	RTRAF	0.976	0.13		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
NEMF	RTCB	0.973	0.162		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
DEK	RTCB	0.97	0.118		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
PDAP1	NEMF	0.964	0.098		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RTRAF	CAPRIN1	0.961	0.15		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM
G3BP1	RTCB	0.958	0.25		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only
RTRAF	FAM98B	0.953	0.61	structurally_consistent (dimer)	bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction
DEK	G3BP1	0.903	0.182		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DEK	NEMF	0.883	0.062		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
FAM98A	G3BP1	0.863	0.188		hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM
CAPRIN1	RTCB	0.818	0.154		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only
PDAP1	DEK	0.679	0.156		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
NEMF	CAPRIN1	0.579	0.098		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
PDAP1	G3BP1	0.554	0.284		hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
FAM98A	NEMF	0.528	0.342		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
FAM98B	RTCB	0.525	0.686		bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
PDAP1	RTCB	0.498	0.08		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
FAM98A	CAPRIN1	0.356	0.312		hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
NEMF	FAM98B	0.184	0.042		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
FAM98A	FAM98B	0.121	0.04	mutually_exclusive (Q9Y224)	bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM
DEK	CAPRIN1	0.028	0.122		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
FAM98B	CAPRIN1	0.016	0.068		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
FAM98B	G3BP1	0.013	0.118		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DEK	FAM98B	0.012	0.1		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PDAP1	CAPRIN1	0.007	0.268		youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
DEK	FAM98A	0.006	0.054		hein_WMM bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM
PDAP1	FAM98B	0.005	0.068		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PDAP1	FAM98A	0.004	0.1		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM

Related Complexes

Genename	Complexes
PDAP1	huMAP3_00117.1 huMAP3_02515.1 huMAP3_04065.1 huMAP3_04560.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
RTRAF	huMAP3_00117.1 huMAP3_02515.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
DEK	huMAP3_00117.1 huMAP3_02515.1 huMAP3_04351.1 huMAP3_06521.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09423.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
NEMF	huMAP3_00371.1 huMAP3_02373.1 huMAP3_06629.1 huMAP3_07298.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07574.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_08872.1 huMAP3_09457.1 huMAP3_09507.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10359.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11021.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
CAPRIN1	huMAP3_01928.1 huMAP3_02784.1 huMAP3_04258.1 huMAP3_04327.1 huMAP3_05303.1 huMAP3_05711.1 huMAP3_06888.1 huMAP3_07425.1 huMAP3_07909.1 huMAP3_07963.1 huMAP3_08326.1 huMAP3_08526.1 huMAP3_09383.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10207.1 huMAP3_10307.1 huMAP3_10364.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
G3BP1	huMAP3_01928.1 huMAP3_03324.1 huMAP3_04258.1 huMAP3_04327.1 huMAP3_04441.1 huMAP3_06680.1 huMAP3_07425.1 huMAP3_08326.1 huMAP3_09383.1 huMAP3_09891.1 huMAP3_10307.1 huMAP3_10364.1 huMAP3_10440.1 huMAP3_10631.1 huMAP3_10943.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
FAM98A	huMAP3_00232.1 huMAP3_02515.1 huMAP3_06888.1 huMAP3_07425.1 huMAP3_08003.1 huMAP3_09988.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
FAM98B	huMAP3_00810.1 huMAP3_02376.1 huMAP3_02778.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_10307.1 huMAP3_10616.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
RTCB	huMAP3_02515.1 huMAP3_04351.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09423.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07425.1

Complex Portal: CPX-20047