hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07430.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TICRR | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | 5 | UniProt NCBI |
| HELB | DNA helicase B (hDHB) (EC 3.6.4.12) | 5 | UniProt NCBI |
| CCNA1 | Cyclin-A1 | 5 | UniProt NCBI |
| CCNA2 | Cyclin-A2 (Cyclin-A) (Cyclin A) | 5 | UniProt NCBI |
| SCAPER | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-170145 | 4.55977246808e-05 | 0.4 | CCNA2 CCNA1 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| REAC:R-HSA-68911 | 0.000151950811602 | 0.4 | CCNA2 CCNA1 | G2 Phase |
| KEGG:04110 | 0.000516961308947 | 0.6 | CCNA2 TICRR CCNA1 | Cell cycle |
| REAC:R-HSA-6804116 | 0.0011839189519 | 0.4 | CCNA2 CCNA1 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| REAC:R-HSA-171319 | 0.00383489202506 | 0.4 | CCNA2 CCNA1 | Telomere Extension By Telomerase |
| REAC:R-HSA-69273 | 0.00454605723789 | 0.4 | CCNA2 CCNA1 | Cyclin A/B1/B2 associated events during G2/M transition |
| REAC:R-HSA-1538133 | 0.00492422076745 | 0.4 | CCNA2 CCNA1 | G0 and Early G1 |
| KEGG:05221 | 0.00771708586936 | 0.4 | CCNA2 CCNA1 | Acute myeloid leukemia |
| REAC:R-HSA-6804757 | 0.00900400267976 | 0.4 | CCNA2 CCNA1 | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.00953234360475 | 0.4 | CCNA2 CCNA1 | Regulation of TP53 Expression and Degradation |
| WP:WP5293 | 0.00998567643899 | 0.4 | CCNA2 CCNA1 | Acute myeloid leukemia |
| WP:WP1403 | 0.010677250915 | 0.4 | CCNA2 CCNA1 | AMP activated protein kinase signaling |
| GO:0097124 | 0.0140440992017 | 0.4 | CCNA2 CCNA1 | cyclin A2-CDK2 complex |
| KEGG:04914 | 0.0149314441262 | 0.4 | CCNA2 CCNA1 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-6791312 | 0.0149609318958 | 0.4 | CCNA2 CCNA1 | TP53 Regulates Transcription of Cell Cycle Genes |
| REAC:R-HSA-180786 | 0.0192520251047 | 0.4 | CCNA2 CCNA1 | Extension of Telomeres |
| REAC:R-HSA-187577 | 0.0266933781073 | 0.4 | CCNA2 CCNA1 | SCF(Skp2)-mediated degradation of p27/p21 |
| KEGG:04152 | 0.028330266578 | 0.4 | CCNA2 CCNA1 | AMPK signaling pathway |
| REAC:R-HSA-69580 | 0.0303866302294 | 0.4 | CCNA2 CCNA1 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 0.0303866302294 | 0.4 | CCNA2 CCNA1 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-69615 | 0.0323221445549 | 0.4 | CCNA2 CCNA1 | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-2559586 | 0.0333121022189 | 0.4 | CCNA2 CCNA1 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-68949 | 0.0363707033179 | 0.4 | CCNA2 CCNA1 | Orc1 removal from chromatin |
| REAC:R-HSA-174184 | 0.0374197925333 | 0.4 | CCNA2 CCNA1 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-69017 | 0.0374197925333 | 0.4 | CCNA2 CCNA1 | CDK-mediated phosphorylation and removal of Cdc6 |
| REAC:R-HSA-179419 | 0.0384836492499 | 0.4 | CCNA2 CCNA1 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| WP:WP179 | 0.0386238148414 | 0.4 | CCNA2 CCNA1 | Cell cycle |
| REAC:R-HSA-176409 | 0.0406556405791 | 0.4 | CCNA2 CCNA1 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176814 | 0.0417637628913 | 0.4 | CCNA2 CCNA1 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| KEGG:04218 | 0.0433995507999 | 0.4 | CCNA2 CCNA1 | Cellular senescence |
| REAC:R-HSA-176408 | 0.0463436196778 | 0.4 | CCNA2 CCNA1 | Regulation of APC/C activators between G1/S and early anaphase |
| KEGG:05161 | 0.0484667159694 | 0.4 | CCNA2 CCNA1 | Hepatitis B |
| CORUM:5556 | 0.0498708842806 | 0.2 | CCNA2 | CDK2-CCNA2 complex |
| REAC:R-HSA-69202 | 0.0499330761364 | 0.4 | CCNA2 CCNA1 | Cyclin E associated events during G1/S transition |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SCAPER | CCNA2 | 0.999 | 0.176 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CCNA2 | CCNA1 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TICRR | CCNA2 | 0.955 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CCNA2 | HELB | 0.952 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CCNA1 | HELB | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| TICRR | HELB | 0.572 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| TICRR | CCNA1 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCAPER | HELB | 0.502 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| SCAPER | CCNA1 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| TICRR | SCAPER | 0.487 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes