hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07432.1
Complex Portal: CPX-23554
Confidence: Very High  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| APOA2 | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] | 5 | UniProt   NCBI |
| ORM2 | Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2) | 5 | UniProt   NCBI |
| CP | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) | 5 | UniProt   NCBI |
| AHSG | Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] | 5 | UniProt   NCBI |
| A1BG | Alpha-1B-glycoprotein (Alpha-1-B glycoprotein) | 5 | UniProt   NCBI |
| C4A | Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain] | 5 | UniProt   NCBI |
| ORM1 | Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) | 5 | UniProt   NCBI |
| ALB | Albumin | 5 | UniProt   NCBI |
| C3 | Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] | 5 | UniProt   NCBI |
| HPX | Hemopexin (Beta-1B-glycoprotein) | 5 | UniProt   NCBI |
| FGB | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | 5 | UniProt   NCBI |
| HP | Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] | 5 | UniProt   NCBI |
| APOA4 | Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4) | 5 | UniProt   NCBI |
| FGA | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | 5 | UniProt   NCBI |
| SERPINA3 | Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less] | 5 | UniProt   NCBI |
| TF | Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) | 5 | UniProt   NCBI |
| APOA1 | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | 5 | UniProt   NCBI |
| SERPINA1 | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   GO:0072562 | 5.539446635e-30 | 0.941176470588 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP FGB HPX AHSG C4A TF SERPINA3 APOA2 | blood microparticle |
|   REAC:R-HSA-8957275 | 1.98682878462e-16 | 0.588235294118 | APOA2 C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | Post-translational protein phosphorylation |
|   REAC:R-HSA-381426 | 8.54773597472e-16 | 0.588235294118 | APOA2 C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
|   REAC:R-HSA-114608 | 1.42140341106e-15 | 0.588235294118 | SERPINA3 A1BG ORM1 ALB TF FGB SERPINA1 FGA AHSG APOA1 | Platelet degranulation |
|   REAC:R-HSA-76005 | 2.30565268436e-15 | 0.588235294118 | SERPINA3 A1BG ORM1 ALB TF FGB SERPINA1 FGA AHSG APOA1 | Response to elevated platelet cytosolic Ca2+ |
|   GO:0034774 | 8.06847630449e-13 | 0.705882352941 | SERPINA3 A1BG ORM1 C3 ALB HP FGB SERPINA1 FGA AHSG TF APOA1 | secretory granule lumen |
|   GO:0060205 | 8.77312196037e-13 | 0.705882352941 | SERPINA3 A1BG ORM1 C3 ALB HP FGB SERPINA1 FGA AHSG TF APOA1 | cytoplasmic vesicle lumen |
|   GO:0031983 | 9.14617063152e-13 | 0.705882352941 | SERPINA3 A1BG ORM1 C3 ALB HP FGB SERPINA1 FGA AHSG TF APOA1 | vesicle lumen |
|   REAC:R-HSA-76002 | 2.42457518384e-12 | 0.588235294118 | SERPINA3 A1BG ORM1 ALB TF FGB SERPINA1 FGA AHSG APOA1 | Platelet activation, signaling and aggregation |
|   GO:0005788 | 1.45570893238e-11 | 0.647058823529 | APOA4 APOA2 C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | endoplasmic reticulum lumen |
|   GO:0070062 | 2.16162139492e-11 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular exosome |
|   GO:1903561 | 2.53110256857e-11 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular vesicle |
|   GO:0065010 | 2.55458987407e-11 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular membrane-bounded organelle |
|   GO:0043230 | 2.55458987407e-11 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular organelle |
|   GO:0031093 | 3.26378560155e-11 | 0.470588235294 | SERPINA3 A1BG ORM1 ALB FGB FGA AHSG SERPINA1 | platelet alpha granule lumen |
|   GO:0031091 | 3.83609859672e-10 | 0.470588235294 | SERPINA3 A1BG ORM1 ALB FGB FGA AHSG SERPINA1 | platelet alpha granule |
|   GO:0005615 | 5.99482720959e-09 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular space |
|   GO:0062023 | 1.01317010628e-08 | 0.588235294118 | APOA4 A1BG ORM1 APOA1 FGB SERPINA1 HPX AHSG SERPINA3 FGA | collagen-containing extracellular matrix |
|   GO:0030141 | 1.36817899771e-08 | 0.705882352941 | SERPINA3 A1BG ORM1 C3 ALB HP FGB SERPINA1 FGA AHSG TF APOA1 | secretory granule |
|   REAC:R-HSA-109582 | 1.64444625617e-08 | 0.588235294118 | SERPINA3 A1BG ORM1 ALB TF FGB SERPINA1 FGA AHSG APOA1 | Hemostasis |
|   WP:WP2806 | 2.35539451368e-08 | 0.352941176471 | APOA1 C3 ALB FGB FGA C4A | Complement system |
|   GO:0005576 | 3.14653580475e-08 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | extracellular region |
|   GO:0031410 | 3.41202230177e-08 | 0.882352941176 | FGA APOA4 APOA2 FGB C3 ALB HP APOA1 ORM1 SERPINA1 HPX AHSG TF SERPINA3 A1BG | cytoplasmic vesicle |
|   GO:0097708 | 3.50470472693e-08 | 0.882352941176 | FGA APOA4 APOA2 FGB C3 ALB HP APOA1 ORM1 SERPINA1 HPX AHSG TF SERPINA3 A1BG | intracellular vesicle |
|   WP:WP5115 | 5.3152016662e-08 | 0.411764705882 | ALB APOA2 TF HP FGB FGA APOA1 | Network map of SARS CoV 2 signaling pathway |
|   GO:0099503 | 7.12714480063e-08 | 0.705882352941 | SERPINA3 A1BG ORM1 C3 ALB HP FGB SERPINA1 FGA AHSG TF APOA1 | secretory vesicle |
|   GO:0031012 | 7.75100140188e-08 | 0.588235294118 | APOA4 A1BG ORM1 APOA1 FGB SERPINA1 HPX AHSG SERPINA3 FGA | extracellular matrix |
|   GO:0030312 | 7.75100140188e-08 | 0.588235294118 | APOA4 A1BG ORM1 APOA1 FGB SERPINA1 HPX AHSG SERPINA3 FGA | external encapsulating structure |
|   GO:0031982 | 8.67526033869e-08 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | vesicle |
|   REAC:R-HSA-2168880 | 1.98856868286e-07 | 0.235294117647 | APOA1 ALB HP HPX | Scavenging of heme from plasma |
|   WP:WP176 | 4.25690851579e-07 | 0.294117647059 | APOA1 FGB ALB SERPINA3 FGA | Folate metabolism |
|   KEGG:04610 | 8.36387187519e-07 | 0.294117647059 | C4A SERPINA1 FGB FGA C3 | Complement and coagulation cascades |
|   WP:WP15 | 1.2642568698e-06 | 0.294117647059 | APOA1 FGB ALB SERPINA3 FGA | Selenium micronutrient network |
|   REAC:R-HSA-168249 | 2.76868840416e-06 | 0.588235294118 | SERPINA3 A1BG ORM1 C3 HP FGB FGA C4A AHSG SERPINA1 | Innate Immune System |
|   REAC:R-HSA-8963899 | 5.94628263852e-06 | 0.235294117647 | APOA1 APOA4 APOA2 ALB | Plasma lipoprotein remodeling |
|   REAC:R-HSA-2173782 | 2.06927819386e-05 | 0.235294117647 | APOA1 ALB HP HPX | Binding and Uptake of Ligands by Scavenger Receptors |
|   WP:WP5110 | 2.43700568861e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Familial hyperlipidemia type 3 |
|   WP:WP5112 | 3.24700585643e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Familial hyperlipidemia type 5 |
|   REAC:R-HSA-8963901 | 3.52693350722e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Chylomicron remodeling |
|   GO:0012505 | 3.52840263598e-05 | 0.941176470588 | APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB FGA AHSG C4A TF SERPINA3 APOA2 | endomembrane system |
|   WP:WP5109 | 4.21807419431e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Familial hyperlipidemia type 2 |
|   REAC:R-HSA-8963888 | 5.03485570596e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Chylomicron assembly |
|   REAC:R-HSA-597592 | 6.32468057244e-05 | 0.588235294118 | APOA2 C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | Post-translational protein modification |
|   WP:WP5108 | 6.70093109926e-05 | 0.176470588235 | APOA4 APOA2 APOA1 | Familial hyperlipidemia type 1 |
|   GO:0045807 | 7.74762249428e-05 | 0.352941176471 | APOA1 C3 TF C4A AHSG APOA2 | positive regulation of endocytosis |
|   REAC:R-HSA-6798695 | 8.69702899886e-05 | 0.411764705882 | SERPINA3 A1BG C3 HP ORM1 SERPINA1 AHSG | Neutrophil degranulation |
|   GO:0005783 | 9.63184154648e-05 | 0.705882352941 | APOA4 APOA2 FGB C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | endoplasmic reticulum |
|   WP:WP5111 | 0.000100001896091 | 0.176470588235 | APOA4 APOA2 APOA1 | Familial hyperlipidemia type 4 |
|   REAC:R-HSA-392499 | 0.000109786181458 | 0.647058823529 | APOA4 APOA2 C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | Metabolism of proteins |
|   GO:0060627 | 0.000125614466333 | 0.470588235294 | APOA2 C3 TF FGB FGA C4A AHSG APOA1 | regulation of vesicle-mediated transport |
|   GO:0050766 | 0.000140221868392 | 0.294117647059 | APOA1 AHSG C3 APOA2 C4A | positive regulation of phagocytosis |
|   CORUM:6417 | 0.000163158265417 | 0.117647058824 | FGB FGA | Fibrinogen complex |
|   REAC:R-HSA-174824 | 0.000189310248205 | 0.235294117647 | APOA1 APOA4 APOA2 ALB | Plasma lipoprotein assembly, remodeling, and clearance |
|   WP:WP430 | 0.000225662254027 | 0.176470588235 | APOA4 APOA2 APOA1 | Statin inhibition of cholesterol production |
|   REAC:R-HSA-8963898 | 0.000233948650926 | 0.176470588235 | APOA4 APOA2 APOA1 | Plasma lipoprotein assembly |
|   GO:0031974 | 0.000277956239225 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | membrane-enclosed lumen |
|   GO:0043233 | 0.000277956239225 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | organelle lumen |
|   GO:0070013 | 0.000277956239225 | 1.0 | FGA APOA4 A1BG ORM1 C3 ALB HP APOA1 CP SERPINA1 FGB HPX AHSG C4A TF SERPINA3 APOA2 | intracellular organelle lumen |
|   CORUM:6819 | 0.000326093232852 | 0.117647058824 | C3 APOA1 | APOL1 complex A (APOL1, APOA1, HPR, C3) |
|   GO:0060228 | 0.000652677252708 | 0.176470588235 | APOA4 APOA2 APOA1 | phosphatidylcholine-sterol O-acyltransferase activator activity |
|   GO:0050764 | 0.000693364978453 | 0.294117647059 | APOA1 AHSG C3 APOA2 C4A | regulation of phagocytosis |
|   KEGG:04979 | 0.000817825846008 | 0.176470588235 | APOA4 APOA2 APOA1 | Cholesterol metabolism |
|   HPA:0271152 | 0.00104955067605 | 0.235294117647 | C3 SERPINA1 ALB FGB | kidney; proximal tubules (microvilli)[>=Medium] |
|   REAC:R-HSA-168256 | 0.00119192973801 | 0.588235294118 | SERPINA3 A1BG ORM1 C3 HP FGB FGA C4A AHSG SERPINA1 | Immune System |
|   HPA:0271151 | 0.00129867913367 | 0.235294117647 | C3 SERPINA1 ALB FGB | kidney; proximal tubules (microvilli)[>=Low] |
|   WP:WP1533 | 0.00165819308905 | 0.176470588235 | SERPINA3 ALB APOA1 | Vitamin B12 metabolism |
|   WP:WP4927 | 0.00216481322863 | 0.117647058824 | FGB FGA | COVID 19 thrombosis and anticoagulation |
|   WP:WP558 | 0.00233372025386 | 0.176470588235 | C3 SERPINA1 FGB | Complement and coagulation cascades |
|   GO:0051050 | 0.00269999714629 | 0.470588235294 | APOA2 C3 TF FGB FGA C4A AHSG APOA1 | positive regulation of transport |
|   GO:0030100 | 0.00277441279737 | 0.352941176471 | APOA1 C3 TF C4A AHSG APOA2 | regulation of endocytosis |
|   HP:0005268 | 0.00283282072605 | 0.176470588235 | FGB ALB FGA | Miscarriage |
|   GO:1905918 | 0.00364711882004 | 0.176470588235 | APOA4 APOA2 APOA1 | regulation of CoA-transferase activity |
|   GO:1905920 | 0.00364711882004 | 0.176470588235 | APOA4 APOA2 APOA1 | positive regulation of CoA-transferase activity |
|   WP:WP3601 | 0.00403545676893 | 0.117647058824 | APOA2 APOA1 | Lipid particles composition |
|   REAC:R-HSA-975634 | 0.00405691277329 | 0.176470588235 | APOA4 APOA2 APOA1 | Retinoid metabolism and transport |
|   HP:0032385 | 0.0041498950117 | 0.117647058824 | ALB TF | Abnormal circulating transferrin concentration |
|   HP:0034287 | 0.0041498950117 | 0.117647058824 | FGB FGA | Afibrinogenemia |
|   HP:0400008 | 0.0041498950117 | 0.117647058824 | FGB FGA | Menometrorrhagia |
|   KEGG:05171 | 0.00441585259625 | 0.235294117647 | C4A FGB FGA C3 | Coronavirus disease - COVID-19 |
|   REAC:R-HSA-6806667 | 0.00505652633168 | 0.176470588235 | APOA4 APOA2 APOA1 | Metabolism of fat-soluble vitamins |
|   WP:WP5304 | 0.00512792420891 | 0.176470588235 | APOA4 APOA2 APOA1 | Cholesterol metabolism |
|   GO:0034372 | 0.00546674693619 | 0.176470588235 | APOA4 APOA2 APOA1 | very-low-density lipoprotein particle remodeling |
|   GO:0034370 | 0.00546674693619 | 0.176470588235 | APOA4 APOA2 APOA1 | triglyceride-rich lipoprotein particle remodeling |
|   REAC:R-HSA-8964058 | 0.00614527626193 | 0.117647058824 | ALB APOA1 | HDL remodeling |
|   REAC:R-HSA-382551 | 0.00647732317483 | 0.352941176471 | APOA4 APOA1 TF ALB CP APOA2 | Transport of small molecules |
|   HP:0000100 | 0.00677437455466 | 0.235294117647 | C3 SERPINA1 FGA APOA1 | Nephrotic syndrome |
|   GO:0033700 | 0.00780402634424 | 0.176470588235 | APOA4 APOA2 APOA1 | phospholipid efflux |
|   REAC:R-HSA-174577 | 0.00859750008678 | 0.117647058824 | C4A C3 | Activation of C3 and C5 |
|   WP:WP5172 | 0.0112032282492 | 0.117647058824 | CP TF | Iron metabolism disorders |
|   WP:WP4522 | 0.0130614919572 | 0.117647058824 | APOA2 APOA1 | Metabolic pathway of LDL HDL and TG including diseases |
|   REAC:R-HSA-5653656 | 0.0132528700542 | 0.352941176471 | APOA1 TF ALB SERPINA1 HP HPX | Vesicle-mediated transport |
|   HP:0000007 | 0.0134001161929 | 0.647058823529 | APOA2 FGB C3 ALB TF CP SERPINA1 FGA AHSG C4A APOA1 | Autosomal recessive inheritance |
|   HP:0100310 | 0.013814058389 | 0.117647058824 | FGB FGA | Epidural hemorrhage |
|   HP:0012223 | 0.013814058389 | 0.117647058824 | FGB FGA | Splenic rupture |
|   KEGG:04977 | 0.0144151856325 | 0.117647058824 | APOA4 APOA1 | Vitamin digestion and absorption |
|   GO:0043691 | 0.018559526455 | 0.176470588235 | APOA4 APOA2 APOA1 | reverse cholesterol transport |
|   GO:0034375 | 0.018559526455 | 0.176470588235 | APOA4 APOA2 APOA1 | high-density lipoprotein particle remodeling |
|   GO:0120020 | 0.018559526455 | 0.176470588235 | APOA4 APOA2 APOA1 | cholesterol transfer activity |
|   GO:0034361 | 0.018559526455 | 0.176470588235 | APOA4 APOA2 APOA1 | very-low-density lipoprotein particle |
|   GO:0034385 | 0.018559526455 | 0.176470588235 | APOA4 APOA2 APOA1 | triglyceride-rich plasma lipoprotein particle |
|   WP:WP545 | 0.019480441964 | 0.117647058824 | C4A C3 | Complement activation |
|   HP:0025465 | 0.0207069091434 | 0.117647058824 | ALB TF | Abnormal circulating beta globulin level |
|   HP:0003216 | 0.0207069091434 | 0.117647058824 | FGA APOA1 | Generalized amyloid deposition |
|   TF:M11626_1 | 0.0216315357764 | 0.529411764706 | APOA4 APOA1 FGB ALB HP CP HPX TF FGA | Factor: Sox-9; motif: NNNACAATRG; match class: 1 |
|   WP:WP272 | 0.0219005077051 | 0.117647058824 | FGB FGA | Blood clotting cascade |
|   REAC:R-HSA-354194 | 0.0224557028643 | 0.117647058824 | FGB FGA | GRB2:SOS provides linkage to MAPK signaling for Integrins |
|   GO:0120015 | 0.0236042404358 | 0.176470588235 | APOA4 APOA2 APOA1 | sterol transfer activity |
|   HP:0011025 | 0.0251134452897 | 0.470588235294 | APOA1 FGB C3 ALB TF CP FGA C4A | Abnormal cardiovascular system physiology |
|   GO:0006952 | 0.026741410263 | 0.529411764706 | APOA4 APOA1 ORM1 HP TF FGB FGA AHSG SERPINA3 | defense response |
|   REAC:R-HSA-372708 | 0.0269284088232 | 0.117647058824 | FGB FGA | p130Cas linkage to MAPK signaling for integrins |
|   HP:0011884 | 0.0289698372489 | 0.117647058824 | FGB FGA | Abnormal umbilical stump bleeding |
|   GO:0034364 | 0.0294840968368 | 0.176470588235 | APOA4 APOA2 APOA1 | high-density lipoprotein particle |
|   GO:0051049 | 0.0295483407729 | 0.529411764706 | APOA4 APOA2 C3 TF FGB FGA C4A AHSG APOA1 | regulation of transport |
|   WP:WP2878 | 0.0299978875622 | 0.117647058824 | APOA2 APOA1 | PPAR alpha pathway |
|   HP:0034241 | 0.0303149978899 | 0.176470588235 | FGB ALB FGA | Prenatal death |
|   REAC:R-HSA-2187338 | 0.030396175383 | 0.176470588235 | APOA4 APOA2 APOA1 | Visual phototransduction |
|   HP:0012614 | 0.0304834535295 | 0.235294117647 | APOA1 C4A FGA C3 | Abnormal urine cytology |
|   HP:0000790 | 0.0304834535295 | 0.235294117647 | APOA1 C4A FGA C3 | Hematuria |
|   KEGG:04975 | 0.0327782089177 | 0.117647058824 | APOA4 APOA1 | Fat digestion and absorption |
|   GO:0006909 | 0.0362495523217 | 0.294117647059 | APOA1 AHSG C3 APOA2 C4A | phagocytosis |
|   HP:0001939 | 0.0363836456747 | 0.588235294118 | APOA2 FGB C3 ALB TF CP SERPINA1 FGA C4A APOA1 | Abnormality of metabolism/homeostasis |
|   REAC:R-HSA-5603041 | 0.0370777836204 | 0.117647058824 | FGB FGA | IRAK4 deficiency (TLR2/4) |
|   REAC:R-HSA-5602498 | 0.0370777836204 | 0.117647058824 | FGB FGA | MyD88 deficiency (TLR2/4) |
|   KEGG:04613 | 0.0383515051049 | 0.176470588235 | C3 FGA FGB | Neutrophil extracellular trap formation |
|   HP:0032179 | 0.038600021268 | 0.117647058824 | ALB TF | Abnormal circulating globulin concentration |
|   GO:0071944 | 0.0404175732552 | 0.823529411765 | APOA4 A1BG ORM1 C3 TF APOA1 CP SERPINA1 FGB HPX AHSG C4A SERPINA3 FGA | cell periphery |
|   REAC:R-HSA-5686938 | 0.0427527934113 | 0.117647058824 | FGB FGA | Regulation of TLR by endogenous ligand |
|   KEGG:04216 | 0.0472775110763 | 0.117647058824 | CP TF | Ferroptosis |
|   REAC:R-HSA-166663 | 0.0488269140913 | 0.117647058824 | C4A C3 | Initial triggering of complement |
|   HP:0030137 | 0.0495946438232 | 0.117647058824 | FGB FGA | Prolonged bleeding following circumcision |
|   HP:0010874 | 0.0495946438232 | 0.117647058824 | APOA2 APOA1 | Tendon xanthomatosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  ORM1 |  ORM2 | 1.0 | 0.716           |
structurally_consistent (dimer)        
|
|  C3 |  APOA1 | 0.993 | 0.49           |          |
|  SERPINA1 |  FGA | 0.992 | 0.416           |          |
|  FGA |  APOA1 | 0.991 | 0.366           |          |
|  AHSG |  APOA1 | 0.991 | 0.346           |          |
|  FGB |  APOA1 | 0.991 | 0.408           |          |
|  SERPINA1 |  TF | 0.991 | 0.42           |          |
|  SERPINA1 |  FGB | 0.988 | 0.418           |          |
|  SERPINA1 |  C3 | 0.988 | 0.492           |          |
|  APOA2 |  APOA1 | 0.987 | 0.468           |          |
|  AHSG |  ALB | 0.987 | 0.52           |
mutually_exclusive (O43240)        
|
|  SERPINA1 |  APOA1 | 0.986 | 0.45           |          |
|  ORM1 |  APOA1 | 0.985 | 0.492           |          |
|  HP |  C3 | 0.985 | 0.44           |          |
|  APOA2 |  HPX | 0.985 | 0.468           |          |
|  APOA2 |  CP | 0.985 | 0.554           |          |
|  TF |  APOA1 | 0.985 | 0.37           |          |
|  HP |  CP | 0.984 | 0.306           |          |
|  CP |  APOA1 | 0.984 | 0.192           |          |
|  AHSG |  HPX | 0.984 | 0.306           |          |
|  AHSG |  ORM1 | 0.984 | 0.282           |
mutually_exclusive (O43240)        
|
|  AHSG |  HP | 0.984 | 0.326           |          |
|  AHSG |  CP | 0.984 | 0.086           |          |
|  FGB |  FGA | 0.984 | 0.312           |
structurally_consistent (dimer)        
|
|  ORM1 |  HP | 0.984 | 0.77           |
mixed_interface        
|
|  ORM2 |  CP | 0.984 | 0.648           |
structurally_consistent (O15547)        
|
|  HP |  APOA1 | 0.983 | 0.458           |          |
|  AHSG |  SERPINA1 | 0.983 | 0.352           |
structurally_consistent (dimer)        
|
|  ORM2 |  HPX | 0.983 | 0.531           |          |
|  CP |  HPX | 0.983 | 0.36           |          |
|  HPX |  SERPINA3 | 0.982 | 0.612           |          |
|  ORM1 |  HPX | 0.982 | 0.376           |          |
|  ORM1 |  CP | 0.982 | 0.672           |          |
|  HP |  HPX | 0.982 | 0.528           |          |
|  ORM1 |  SERPINA3 | 0.982 | 0.77           |          |
|  HP |  SERPINA3 | 0.982 | 0.342           |          |
|  FGA |  TF | 0.982 | 0.306           |          |
|  CP |  C3 | 0.981 | 0.25           |          |
|  CP |  SERPINA3 | 0.981 | 0.26           |
structurally_consistent (O15547)        
|
|  APOA4 |  CP | 0.981 | 0.494           |          |
|  CP |  A1BG | 0.981 | 0.532           |          |
|  SERPINA3 |  APOA1 | 0.981 | 0.388           |          |
|  AHSG |  APOA2 | 0.981 | 0.416           |          |
|  C3 |  TF | 0.979 | 0.49           |          |
|  HPX |  C3 | 0.979 | 0.69           |          |
|  FGB |  C3 | 0.979 | 0.562           |          |
|  APOA4 |  HPX | 0.979 | 0.404           |          |
|  A1BG |  HPX | 0.978 | 0.606           |          |
|  ORM1 |  SERPINA1 | 0.978 | 0.648           |
mutually_exclusive (O43240)        
|
|  AHSG |  C3 | 0.978 | 0.394           |          |
|  APOA2 |  C3 | 0.977 | 0.376963855422           |          |
|  HP |  APOA2 | 0.977 | 0.412           |          |
|  APOA4 |  APOA1 | 0.977 | 0.372           |          |
|  AHSG |  APOA4 | 0.977 | 0.138           |
structurally_consistent (dimer)        
|
|  ORM1 |  APOA4 | 0.977 | 0.406           |          |
|  APOA4 |  C3 | 0.977 | 0.296           |          |
|  SERPINA1 |  SERPINA3 | 0.977 | 0.388           |
mutually_exclusive (O43924)        
|
|  HP |  SERPINA1 | 0.976 | 0.372           |          |
|  ORM1 |  APOA2 | 0.974 | 0.65           |          |
|  APOA4 |  APOA2 | 0.974 | 0.454           |          |
|  AHSG |  ORM2 | 0.973 | 0.356           |
mutually_exclusive (P01009)        
|
|  FGB |  TF | 0.972 | 0.352           |          |
|  C3 |  FGA | 0.972 | 0.428           |          |
|  ORM1 |  TF | 0.972 | 0.374           |          |
|  APOA2 |  A1BG | 0.972 | 0.41           |          |
|  C3 |  SERPINA3 | 0.971 | 0.366           |          |
|  APOA2 |  SERPINA3 | 0.971 | 0.52           |          |
|  APOA4 |  TF | 0.971 | 0.244           |          |
|  HP |  ORM2 | 0.969 | 0.794           |          |
|  APOA2 |  ORM2 | 0.969 | 0.682           |          |
|  ORM2 |  A1BG | 0.969 | 0.674           |
structurally_consistent (dimer)        
|
|  APOA4 |  HP | 0.968 | 0.43           |
structurally_consistent (P00739)        
|
|  SERPINA1 |  APOA2 | 0.968 | 0.478           |          |
|  HP |  TF | 0.968 | 0.368           |          |
|  AHSG |  SERPINA3 | 0.967 | 0.276           |          |
|  HPX |  APOA1 | 0.966 | 0.486           |          |
|  ORM1 |  C3 | 0.966 | 0.676           |          |
|  HP |  FGA | 0.966 | 0.338           |          |
|  C4A |  ORM1 | 0.966 | 0.492           |          |
|  SERPINA1 |  CP | 0.965 | 0.292           |          |
|  A1BG |  C3 | 0.965 | 0.494           |          |
|  ORM2 |  APOA1 | 0.964 | 0.65           |          |
|  ORM2 |  C3 | 0.964 | 0.698           |          |
|  APOA2 |  TF | 0.963 | 0.282           |          |
|  ORM2 |  SERPINA3 | 0.962 | 0.788           |          |
|  SERPINA1 |  ALB | 0.962 | 0.466           |          |
|  SERPINA1 |  A1BG | 0.962 | 0.6           |          |
|  SERPINA1 |  ORM2 | 0.962 | 0.734           |
structurally_consistent (dimer)        
|
|  C4A |  C3 | 0.961 | 0.474           |          |
|  FGB |  SERPINA3 | 0.961 | 0.268           |          |
|  A1BG |  TF | 0.96 | 0.574           |          |
|  ORM2 |  TF | 0.96 | 0.65           |
structurally_consistent (O15547)        
|
|  ORM1 |  FGA | 0.958 | 0.586           |          |
|  ORM1 |  FGB | 0.956 | 0.656           |
structurally_consistent (dimer)        
|
|  AHSG |  A1BG | 0.956 | 0.33           |          |
|  A1BG |  SERPINA3 | 0.956 | 0.648           |          |
|  A1BG |  APOA1 | 0.956 | 0.498           |          |
|  ORM1 |  A1BG | 0.956 | 0.774           |
mutually_exclusive (P19652)        
|
|  APOA4 |  ALB | 0.955 | 0.454909090909           |          |
|  CP |  TF | 0.954 | 0.21           |          |
|  SERPINA1 |  HPX | 0.953 | 0.576           |          |
|  APOA4 |  A1BG | 0.953 | 0.486           |          |
|  SERPINA3 |  TF | 0.953 | 0.364           |          |
|  APOA4 |  SERPINA1 | 0.952 | 0.3           |
structurally_consistent (P02765)        
|
|  ORM1 |  ALB | 0.951 | 0.652           |
mixed_interface        
|
|  C4A |  HP | 0.95 | 0.398           |          |
|  HPX |  TF | 0.949 | 0.522           |          |
|  C4A |  TF | 0.949 | 0.458           |          |
|  AHSG |  C4A | 0.946 | 0.31           |          |
|  C4A |  APOA2 | 0.945 | 0.496           |          |
|  TF |  ALB | 0.944 | 0.512           |          |
|  AHSG |  TF | 0.944 | 0.412           |          |
|  C4A |  CP | 0.94 | 0.146           |          |
|  APOA4 |  ORM2 | 0.938 | 0.558           |          |
|  HP |  ALB | 0.937 | 0.406           |
mixed_interface        
|
|  APOA2 |  ALB | 0.937 | 0.71           |          |
|  A1BG |  ALB | 0.936 | 0.62           |          |
|  APOA4 |  SERPINA3 | 0.936 | 0.416           |          |
|  C4A |  HPX | 0.935 | 0.402           |          |
|  HP |  A1BG | 0.935 | 0.646           |          |
|  CP |  ALB | 0.934 | 0.356           |          |
|  C4A |  SERPINA3 | 0.933 | 0.218           |          |
|  APOA1 |  ALB | 0.932 | 0.478           |          |
|  HPX |  ALB | 0.93 | 0.614           |          |
|  FGA |  SERPINA3 | 0.93 | 0.3           |          |
|  C4A |  ORM2 | 0.927 | 0.298           |          |
|  HP |  FGB | 0.926 | 0.328           |
mutually_exclusive (P02763)        
|
|  C4A |  SERPINA1 | 0.923 | 0.392           |          |
|  C4A |  APOA1 | 0.921 | 0.292           |          |
|  C3 |  ALB | 0.9 | 0.57           |          |
|  APOA4 |  FGB | 0.891 | 0.362           |          |
|  APOA4 |  FGA | 0.891 | 0.378           |          |
|  FGA |  ALB | 0.891 | 0.416           |
structurally_consistent (P02679)        
|
|  FGB |  ALB | 0.88 | 0.46           |          |
|  AHSG |  FGB | 0.844 | 0.296           |          |
|  HPX |  FGA | 0.837 | 0.604           |          |
|  FGB |  APOA2 | 0.827 | 0.388           |          |
|  APOA2 |  FGA | 0.82 | 0.344           |          |
|  FGB |  CP | 0.797 | 0.29           |          |
|  SERPINA3 |  ALB | 0.795 | 0.416           |          |
|  ORM2 |  ALB | 0.794 | 0.621486179377           |
structurally_consistent (O15547)        
|
|  AHSG |  FGA | 0.765 | 0.15           |          |
|  CP |  FGA | 0.764 | 0.264           |          |
|  FGB |  HPX | 0.721 | 0.41           |          |
|  FGB |  ORM2 | 0.648 | 0.784           |
structurally_consistent (dimer)        
|
|  ORM2 |  FGA | 0.648 | 0.672           |          |
|  C4A |  FGA | 0.637 | 0.252           |          |
|  C4A |  APOA4 | 0.617 | 0.46           |          |
|  C4A |  FGB | 0.544 | 0.482           |          |
|  C4A |  ALB | 0.541 | 0.386           |          |
|  FGB |  A1BG | 0.404 | 0.64           |
mutually_exclusive (P19652)        
|
|  A1BG |  FGA | 0.404 | 0.532           |          |
|  C4A |  A1BG | 0.393 | 0.486           |          |
Related Complexes