hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07433.1
Complex Portal: CPX-16356
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRKCZ | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | 5 | UniProt NCBI |
| PARD6G | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | 5 | UniProt NCBI |
| LLGL1 | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | 5 | UniProt NCBI |
| ZNF3 | Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) | 5 | UniProt NCBI |
| PRKCI | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | 5 | UniProt NCBI |
| NIPSNAP2 | Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence) | 5 | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | 5 | UniProt NCBI |
| PARD6A | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0120157 | 1.13442382344e-12 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | PAR polarity complex |
| GO:0045197 | 7.13269215463e-11 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | establishment or maintenance of epithelial cell apical/basal polarity |
| GO:0061245 | 1.16151397783e-10 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | establishment or maintenance of bipolar cell polarity |
| GO:0035088 | 1.16151397783e-10 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | establishment or maintenance of apical/basal cell polarity |
| KEGG:04530 | 2.4073823255e-10 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | Tight junction |
| KEGG:04390 | 3.24862944239e-10 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | Hippo signaling pathway |
| REAC:R-HSA-420029 | 4.86362738832e-09 | 0.571428571429 | PRKCI PARD6A PARD6G PARD6B | Tight junction interactions |
| CORUM:959 | 7.02338504734e-09 | 0.428571428571 | LLGL1 PARD6B PRKCI | LLGL1-PAR-6B-PRKCI complex |
| WP:WP5090 | 1.40828698166e-08 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | Complement system in neuronal development and plasticity |
| KEGG:05165 | 2.26329306696e-08 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | Human papillomavirus infection |
| KEGG:04015 | 1.91537107548e-07 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | Rap1 signaling pathway |
| GO:0007163 | 4.65983809141e-07 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | establishment or maintenance of cell polarity |
| REAC:R-HSA-421270 | 5.28270435422e-07 | 0.571428571429 | PRKCI PARD6A PARD6G PARD6B | Cell-cell junction organization |
| KEGG:04144 | 1.00924159242e-06 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | Endocytosis |
| GO:0070160 | 2.27164761465e-06 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | tight junction |
| REAC:R-HSA-446728 | 3.63144818167e-06 | 0.571428571429 | PRKCI PARD6A PARD6G PARD6B | Cell junction organization |
| REAC:R-HSA-1500931 | 1.55267215714e-05 | 0.571428571429 | PRKCI PARD6A PARD6G PARD6B | Cell-Cell communication |
| KEGG:04360 | 2.11322925433e-05 | 0.571428571429 | PRKCZ PARD6A PARD6G PARD6B | Axon guidance |
| GO:0005911 | 2.65303205054e-05 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | cell-cell junction |
| GO:1902554 | 4.55453981244e-05 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | serine/threonine protein kinase complex |
| CORUM:7300 | 6.1565588648e-05 | 0.285714285714 | PRKCI PARD6A | PARD3B-PARD6A-PRKCI complex |
| CORUM:956 | 6.1565588648e-05 | 0.285714285714 | PRKCI PARD6B | PAR-3-PAR-6B-PRKCI complex |
| CORUM:955 | 6.1565588648e-05 | 0.285714285714 | PRKCI PARD6B | LLGL2-PAR-6B-PRKCI complex |
| GO:1902911 | 8.64202075381e-05 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | protein kinase complex |
| CORUM:7444 | 0.000123103089524 | 0.285714285714 | PRKCI PARD6A | HOOK2-PAR3-Par6alpha-PKCiota complex |
| CORUM:905 | 0.000205125012531 | 0.285714285714 | PRKCI PARD6A | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| GO:0070161 | 0.00181265007268 | 0.857142857143 | LLGL1 PARD6G PRKCI PARD6A PRKCZ PARD6B | anchoring junction |
| GO:0061695 | 0.00235878261657 | 0.714285714286 | PARD6B PRKCZ PARD6A PARD6G PRKCI | transferase complex, transferring phosphorus-containing groups |
| WP:WP5381 | 0.00265193272199 | 0.428571428571 | LLGL1 PARD6B PRKCI | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-2173791 | 0.00398963152505 | 0.285714285714 | PRKCZ PARD6A | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| WP:WP5283 | 0.00933842806825 | 0.285714285714 | PRKCZ PRKCI | Chronic hyperglycemia impairment of neuron function |
| REAC:R-HSA-194315 | 0.0209047694901 | 0.571428571429 | PRKCZ PARD6A NIPSNAP2 PARD6B | Signaling by Rho GTPases |
| REAC:R-HSA-9013424 | 0.0225049419259 | 0.285714285714 | PARD6A PARD6B | RHOV GTPase cycle |
| REAC:R-HSA-9716542 | 0.0227764210725 | 0.571428571429 | PRKCZ PARD6A NIPSNAP2 PARD6B | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0005938 | 0.0330339860502 | 0.571428571429 | LLGL1 PARD6A PARD6G PARD6B | cell cortex |
| WP:WP5345 | 0.039968890476 | 0.285714285714 | PRKCZ PARD6B | 1p36 copy number variation syndrome |
| KEGG:04611 | 0.047723469919 | 0.285714285714 | PRKCZ PRKCI | Platelet activation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRKCI | PARD6B | 1.0 | 0.106 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| LLGL1 | PARD6B | 1.0 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PRKCZ | PARD6B | 1.0 | 0.168 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PRKCI | LLGL1 | 0.999 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM hein () Malo gupta_WMM fraction treiber_WMM | |
| PRKCI | PRKCZ | 0.999 | 0.336 |
mutually_exclusive (Q9BYG5)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PARD6A | PRKCZ | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PARD6G | PRKCZ | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PARD6G | PARD6B | 0.998 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PRKCZ | LLGL1 | 0.997 | 0.094 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PRKCI | PARD6G | 0.995 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| PRKCZ | NIPSNAP2 | 0.984 | 0.268 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PRKCI | NIPSNAP2 | 0.979 | 0.044 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| ZNF3 | LLGL1 | 0.978 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF3 | PARD6B | 0.962 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PRKCI | PARD6A | 0.959 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| PARD6A | PARD6B | 0.957 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PARD6A | NIPSNAP2 | 0.955 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF3 | PRKCI | 0.952 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| ZNF3 | NIPSNAP2 | 0.95 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| LLGL1 | NIPSNAP2 | 0.949 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PARD6G | PARD6A | 0.887 |
mutually_exclusive (Q05513)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| PARD6A | LLGL1 | 0.862 |
mutually_exclusive (Q05513)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PARD6G | LLGL1 | 0.815 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PARD6B | NIPSNAP2 | 0.439 | 0.094 |
structurally_consistent (Q05513)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ZNF3 | PARD6A | 0.192 | hein_WMM WMM_only | ||
| PARD6G | NIPSNAP2 | 0.099 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF3 | PARD6G | 0.055 | bioplex3_WMM WMM_only | ||
| ZNF3 | PRKCZ | 0.013 | 0.158 | bioplex3_WMM WMM_only |
Related Complexes