hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07439.1
Complex Portal: CPX-20339
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | 5 | UniProt NCBI |
| RHBDF1 | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | 5 | UniProt NCBI |
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | 5 | UniProt NCBI |
| DUSP16 | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | 5 | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | 5 | UniProt NCBI |
| DUSP9 | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP382 | 1.99305621154e-07 | 0.833333333333 | DUSP16 MKNK1 DUSP9 MKNK2 MAPK14 | MAPK signaling pathway |
| KEGG:04010 | 3.73730923895e-07 | 0.833333333333 | DUSP16 MKNK1 DUSP9 MKNK2 MAPK14 | MAPK signaling pathway |
| WP:WP2637 | 3.3828600382e-05 | 0.5 | MKNK1 MKNK2 MAPK14 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-9652817 | 0.000541723162524 | 0.333333333333 | DUSP16 DUSP9 | Signaling by MAPK mutants |
| WP:WP3879 | 0.00210864528598 | 0.333333333333 | MKNK2 MKNK1 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP400 | 0.00436073489596 | 0.333333333333 | MAPK14 MKNK1 | p38 MAPK signaling pathway |
| REAC:R-HSA-112409 | 0.00440152140132 | 0.333333333333 | DUSP16 DUSP9 | RAF-independent MAPK1/3 activation |
| REAC:R-HSA-5675221 | 0.0180324600743 | 0.333333333333 | DUSP16 DUSP9 | Negative regulation of MAPK pathway |
| WP:WP5087 | 0.0221664611486 | 0.5 | MKNK1 MKNK2 MAPK14 | Pleural mesothelioma |
| KEGG:04066 | 0.034648047564 | 0.333333333333 | MKNK2 MKNK1 | HIF-1 signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPK14 | MKNK1 | 0.999 | 0.154 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAPK14 | DUSP16 | 0.986 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MKNK2 | MAPK14 | 0.975 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAPK14 | DUSP9 | 0.975 | 0.146 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RHBDF1 | MAPK14 | 0.968 | 0.04 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MKNK2 | RHBDF1 | 0.568 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MKNK1 | 0.551 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | DUSP16 | 0.527 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP16 | 0.498 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP9 | 0.466 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | DUSP9 | 0.378 | 0.07 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
| RHBDF1 | MKNK1 | 0.364 | 0.108 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
| MKNK1 | DUSP9 | 0.357 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| DUSP16 | DUSP9 | 0.224 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| DUSP16 | MKNK1 | 0.214 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes