hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07454.1

Complex Portal: CPX-25516

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
RPRD1A	Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)	5	UniProt NCBI
POLR2B	DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)	5	UniProt NCBI
POLR2I	DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)	5	UniProt NCBI
SUPT6H	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	5	UniProt NCBI
RPAP2	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2)	5	UniProt NCBI
IWS1	Protein IWS1 homolog (IWS1-like protein)	5	UniProt NCBI
OR4K3	Olfactory receptor 4K3 (Olfactory receptor OR14-14)	3	UniProt NCBI
ASB6	Ankyrin repeat and SOCS box protein 6 (ASB-6)	5	UniProt NCBI
LEO1	RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)	5	UniProt NCBI
ELOA	Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)	5	UniProt NCBI
SKIC8	Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]	5	UniProt NCBI
POLR2J	DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)	5	UniProt NCBI
POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)	3	UniProt NCBI
RECQL5	ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)	5	UniProt NCBI
RPRD2	Regulation of nuclear pre-mRNA domain-containing protein 2	5	UniProt NCBI
SUPT5H	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	5	UniProt NCBI
GTF2F2	General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)	5	UniProt NCBI
LMO2	Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)	5	UniProt NCBI
SUPT4H1	Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)	5	UniProt NCBI
PAF1	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	5	UniProt NCBI
CDC73	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	5	UniProt NCBI
POLR2C	DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)	5	UniProt NCBI
POLR2D	DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)	5	UniProt NCBI
CTR9	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	5	UniProt NCBI
POLR2G	DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)	5	UniProt NCBI
CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)	5	UniProt NCBI
RPRD1B	Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-75955	6.07746378538e-32	0.666666666667	SUPT4H1 POLR2B SUPT6H SUPT5H ELOA CTDP1 POLR2I CDC73 PAF1 IWS1 CTR9 SKIC8 LEO1 POLR2G POLR2D POLR2J	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	6.07746378538e-32	0.666666666667	SUPT4H1 POLR2B SUPT6H SUPT5H ELOA CTDP1 POLR2I CDC73 PAF1 IWS1 CTR9 SKIC8 LEO1 POLR2G POLR2D POLR2J	Formation of RNA Pol II elongation complex
REAC:R-HSA-674695	2.23801772888e-29	0.666666666667	SUPT4H1 POLR2B SUPT6H SUPT5H ELOA CTDP1 POLR2I CDC73 PAF1 IWS1 CTR9 SKIC8 LEO1 POLR2G POLR2D POLR2J	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-73857	2.37296073031e-18	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 POLR2D CTR9 RPRD1B LEO1 RPRD1A POLR2G RPRD2 POLR2J SKIC8	RNA Polymerase II Transcription
REAC:R-HSA-6807505	1.32494791738e-17	0.458333333333	POLR2B POLR2J SUPT5H SUPT4H1 POLR2I POLR2D RPAP2 RPRD1B RPRD1A RPRD2 POLR2G	RNA polymerase II transcribes snRNA genes
REAC:R-HSA-74160	3.27680810842e-17	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 POLR2D CTR9 RPRD1B LEO1 RPRD1A POLR2G RPRD2 POLR2J SKIC8	Gene expression (Transcription)
REAC:R-HSA-167238	6.56833616138e-17	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167243	6.56833616138e-17	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-167290	1.28532342825e-16	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Pausing and recovery of HIV elongation
REAC:R-HSA-167287	1.28532342825e-16	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	HIV elongation arrest and recovery
GO:0006368	5.92674821879e-16	0.5	CTDP1 LEO1 SUPT6H SUPT5H SUPT4H1 POLR2I CDC73 PAF1 IWS1 CTR9 SKIC8 RECQL5	transcription elongation by RNA polymerase II
GO:0016591	1.12605932076e-15	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	RNA polymerase II, holoenzyme
REAC:R-HSA-167242	1.34801337702e-15	0.333333333333	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H POLR2D POLR2G	Abortive elongation of HIV-1 transcript in the absence of Tat
REAC:R-HSA-167200	2.02444434106e-15	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	2.02444434106e-15	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	HIV Transcription Elongation
REAC:R-HSA-167246	2.02444434106e-15	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167152	3.21273864808e-15	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Formation of HIV elongation complex in the absence of HIV Tat
GO:0006354	4.35312777718e-15	0.5	CTDP1 LEO1 SUPT6H SUPT5H SUPT4H1 POLR2I CDC73 PAF1 IWS1 CTR9 SKIC8 RECQL5	DNA-templated transcription elongation
GO:0001098	1.22434402196e-14	0.416666666667	PAF1 SUPT4H1 CDC73 CTDP1 CTR9 RPRD1B LEO1 RECQL5 RPRD1A RPRD2	basal transcription machinery binding
GO:0001099	1.22434402196e-14	0.416666666667	PAF1 SUPT4H1 CDC73 CTDP1 CTR9 RPRD1B LEO1 RECQL5 RPRD1A RPRD2	basal RNA polymerase II transcription machinery binding
GO:0000993	2.14649012518e-14	0.375	PAF1 SUPT4H1 CDC73 CTR9 RPRD1B LEO1 RECQL5 RPRD1A RPRD2	RNA polymerase II complex binding
GO:0055029	3.87130189705e-14	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	nuclear DNA-directed RNA polymerase complex
GO:0000428	4.38702344609e-14	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	DNA-directed RNA polymerase complex
REAC:R-HSA-167158	4.39104172615e-14	0.333333333333	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H POLR2D POLR2G	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-113418	4.39104172615e-14	0.333333333333	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H POLR2D POLR2G	Formation of the Early Elongation Complex
GO:0030880	6.33064086281e-14	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	RNA polymerase complex
GO:0043175	7.17786808977e-14	0.375	PAF1 SUPT4H1 CDC73 CTR9 RPRD1B LEO1 RECQL5 RPRD1A RPRD2	RNA polymerase core enzyme binding
REAC:R-HSA-6796648	7.73610457168e-14	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	TP53 Regulates Transcription of DNA Repair Genes
REAC:R-HSA-167172	2.18414259879e-13	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Transcription of the HIV genome
CORUM:1167	2.31953108889e-13	0.208333333333	PAF1 LEO1 CTR9 CDC73 SKIC8	Paf complex
CORUM:2685	8.98229306449e-13	0.25	POLR2B POLR2G POLR2I CTDP1 POLR2D POLR2J	RNA polymerase II (RNAPII)
GO:0008023	1.02840734586e-12	0.375	ELOA SUPT6H PAF1 SUPT4H1 CDC73 SUPT5H CTR9 SKIC8 LEO1	transcription elongation factor complex
GO:0070063	1.88563123866e-12	0.375	PAF1 SUPT4H1 CDC73 CTR9 RPRD1B LEO1 RECQL5 RPRD1A RPRD2	RNA polymerase binding
CORUM:104	5.81361190776e-11	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA polymerase II core complex
REAC:R-HSA-162599	9.21177895139e-11	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Late Phase of HIV Life Cycle
CORUM:2686	1.06467361663e-10	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	BRCA1-core RNA polymerase II complex
REAC:R-HSA-162587	2.06635755518e-10	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	HIV Life Cycle
GO:0006366	2.19389096398e-10	0.833333333333	SUPT4H1 POLR2B LMO2 SUPT6H SUPT5H ELOA CTDP1 POLR2I CDC73 PAF1 IWS1 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	transcription by RNA polymerase II
KEGG:03020	5.35126956147e-10	0.25	POLR2B POLR2G POLR2I POLR2J2 POLR2D POLR2J	RNA polymerase
REAC:R-HSA-167160	6.71818020912e-10	0.25	POLR2B POLR2G POLR2I SUPT5H POLR2D POLR2J	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-77075	6.71818020912e-10	0.25	POLR2B POLR2G POLR2I SUPT5H POLR2D POLR2J	RNA Pol II CTD phosphorylation and interaction with CE
GO:0005665	8.47797514072e-10	0.25	POLR2B POLR2G POLR2I POLR2J2 POLR2D POLR2J	RNA polymerase II, core complex
REAC:R-HSA-72086	1.09701598337e-09	0.25	POLR2B POLR2G POLR2I SUPT5H POLR2D POLR2J	mRNA Capping
GO:0006351	2.28055233863e-09	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	DNA-templated transcription
CORUM:103	2.65650866056e-09	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA polymerase II holoenzyme complex
GO:0032774	2.83920122607e-09	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	RNA biosynthetic process
CORUM:2825	4.63881528024e-09	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	BRCA1-RNA polymerase II complex
GO:0016593	8.01976412415e-09	0.208333333333	PAF1 LEO1 CTR9 CDC73 SKIC8	Cdc73/Paf1 complex
GO:0061695	8.96925645931e-09	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	transferase complex, transferring phosphorus-containing groups
GO:0005654	9.79439089248e-09	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	nucleoplasm
REAC:R-HSA-162906	1.12933464264e-08	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	HIV Infection
GO:0031124	1.59645540693e-08	0.291666666667	PAF1 CDC73 RPRD2 RPRD1B LEO1 RPRD1A POLR2D	mRNA 3'-end processing
REAC:R-HSA-8851708	1.93608413989e-08	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by FGFR2 IIIa TM
KEGG:03420	2.3252974392e-08	0.25	POLR2B POLR2G POLR2I POLR2J2 POLR2D POLR2J	Nucleotide excision repair
GO:0016070	3.17665831726e-08	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	RNA metabolic process
GO:0034654	3.6946369443e-08	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	nucleobase-containing compound biosynthetic process
GO:0031981	4.24723171882e-08	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	nuclear lumen
GO:0018130	5.3574017895e-08	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	heterocycle biosynthetic process
GO:0019438	5.47460009612e-08	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	aromatic compound biosynthetic process
REAC:R-HSA-203927	7.56243029867e-08	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	MicroRNA (miRNA) biogenesis
REAC:R-HSA-5601884	7.56243029867e-08	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	PIWI-interacting RNA (piRNA) biogenesis
REAC:R-HSA-1839126	9.54218599235e-08	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	FGFR2 mutant receptor activation
REAC:R-HSA-6803529	9.54218599235e-08	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	FGFR2 alternative splicing
GO:1901362	9.87003784887e-08	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	organic cyclic compound biosynthetic process
GO:0097550	3.00824116497e-07	0.208333333333	RPRD1B RPRD1A RECQL5 RPRD2 RPAP2	transcription preinitiation complex
REAC:R-HSA-5655253	3.78565619912e-07	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by FGFR2 in disease
GO:0090304	4.42708697856e-07	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	nucleic acid metabolic process
GO:0140513	4.76275982889e-07	0.625	SUPT4H1 POLR2B SUPT6H PAF1 ELOA POLR2I POLR2J2 POLR2G SUPT5H CTR9 LEO1 SKIC8 CDC73 POLR2D POLR2J	nuclear protein-containing complex
REAC:R-HSA-3700989	4.90794425511e-07	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Transcriptional Regulation by TP53
REAC:R-HSA-168325	1.45180777386e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Viral Messenger RNA Synthesis
GO:0044271	2.10574213736e-06	0.875	SUPT4H1 POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CTDP1 POLR2I CDC73 PAF1 RPAP2 RECQL5 CTR9 RPRD1B LEO1 RPRD1A POLR2G POLR2D POLR2J SKIC8	cellular nitrogen compound biosynthetic process
GO:0031123	2.56773300992e-06	0.291666666667	PAF1 CDC73 RPRD2 RPRD1B LEO1 RPRD1A POLR2D	RNA 3'-end processing
REAC:R-HSA-73779	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-73776	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA Polymerase II Promoter Escape
REAC:R-HSA-76042	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-167162	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-75953	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	RNA Polymerase II Transcription Initiation
REAC:R-HSA-167161	2.68105993429e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	HIV Transcription Initiation
REAC:R-HSA-72165	3.74530777096e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	mRNA Splicing - Minor Pathway
GO:0006139	4.2061808054e-06	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	nucleobase-containing compound metabolic process
REAC:R-HSA-1226099	4.62429414741e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by FGFR in disease
GO:0070013	5.5415495111e-06	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	intracellular organelle lumen
GO:0043233	5.5415495111e-06	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	organelle lumen
GO:0031974	5.5415495111e-06	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	membrane-enclosed lumen
REAC:R-HSA-6781823	5.66005010508e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Formation of TC-NER Pre-Incision Complex
REAC:R-HSA-8866654	6.8724174312e-06	0.208333333333	PAF1 LEO1 CTR9 CDC73 SKIC8	E3 ubiquitin ligases ubiquitinate target proteins
REAC:R-HSA-5654738	7.55145551067e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by FGFR2
REAC:R-HSA-9670095	7.55145551067e-06	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Inhibition of DNA recombination at telomere
GO:0046483	7.82287689362e-06	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	heterocycle metabolic process
GO:0006725	8.35740107869e-06	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	cellular aromatic compound metabolic process
REAC:R-HSA-190236	1.3940437914e-05	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by FGFR
REAC:R-HSA-6782210	1.51257640785e-05	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	1.63897987787e-05	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Dual incision in TC-NER
GO:0016071	1.67782123063e-05	0.458333333333	LEO1 SUPT6H PAF1 CDC73 POLR2D IWS1 RPRD1B SKIC8 RPRD1A RPRD2 POLR2G	mRNA metabolic process
GO:1901360	1.79953731408e-05	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	organic cyclic compound metabolic process
GO:0010467	1.95508948323e-05	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	gene expression
REAC:R-HSA-8852135	3.4253618537e-05	0.208333333333	PAF1 LEO1 CTR9 CDC73 SKIC8	Protein ubiquitination
GO:0001711	3.50368755955e-05	0.166666666667	LEO1 CTR9 CDC73 PAF1	endodermal cell fate commitment
REAC:R-HSA-6781827	4.18762423701e-05	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GO:0034641	4.56576033152e-05	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	cellular nitrogen compound metabolic process
WP:WP405	6.29846213114e-05	0.166666666667	POLR2G POLR2B POLR2I POLR2J	Eukaryotic transcription initiation
GO:0006397	7.57833062255e-05	0.375	PAF1 SUPT6H CDC73 POLR2D IWS1 RPRD1B LEO1 RPRD1A RPRD2	mRNA processing
CORUM:2861	7.83172113594e-05	0.0833333333333	SUPT5H SUPT4H1	DSIF complex (DRB sensitivity-inducing factor complex)
CORUM:2860	7.83172113594e-05	0.0833333333333	SUPT5H SUPT4H1	DSIF complex (DRB sensitivity-inducing factor complex)
REAC:R-HSA-5578749	9.70770214257e-05	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Transcriptional regulation by small RNAs
GO:0009059	0.000111146211939	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	macromolecule biosynthetic process
GO:0034243	0.000118463511905	0.25	SUPT6H SUPT4H1 CDC73 SUPT5H RECQL5 LEO1	regulation of transcription elongation by RNA polymerase II
REAC:R-HSA-157579	0.00015563104072	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Telomere Maintenance
GO:0032991	0.000180496098464	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D POLR2G ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 RPRD1A LMO2 SUPT6H POLR2J CDC73 SUPT5H SKIC8 RPRD2	protein-containing complex
GO:0005634	0.000183015802489	0.958333333333	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B POLR2J2 IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	nucleus
REAC:R-HSA-5617472	0.000208125310876	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	0.000208125310876	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Activation of HOX genes during differentiation
REAC:R-HSA-5696398	0.000228428668013	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Nucleotide Excision Repair
KEGG:05016	0.000238365536336	0.25	POLR2B POLR2G POLR2I POLR2J2 POLR2D POLR2J	Huntington disease
REAC:R-HSA-9824446	0.000267274024762	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Viral Infection Pathways
REAC:R-HSA-211000	0.000354666543495	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Gene Silencing by RNA
GO:0060795	0.000377078861379	0.166666666667	LEO1 CTR9 CDC73 PAF1	cell fate commitment involved in formation of primary germ layer
HPA:0470682	0.000392201839485	0.708333333333	CTDP1 POLR2B SUPT5H SUPT6H IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A RPRD1B RPRD2 POLR2G	skin 2; epidermal cells[>=Medium]
GO:0032784	0.00039368704222	0.25	SUPT6H SUPT4H1 CDC73 SUPT5H RECQL5 LEO1	regulation of DNA-templated transcription elongation
REAC:R-HSA-73886	0.000510329964097	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Chromosome Maintenance
REAC:R-HSA-9018519	0.000510329964097	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Estrogen-dependent gene expression
GO:1990234	0.000590409136866	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	transferase complex
REAC:R-HSA-168273	0.000594796058403	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Influenza Viral RNA Transcription and Replication
HPA:0350472	0.000636359449731	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	pancreas; exocrine glandular cells[>=Medium]
REAC:R-HSA-212436	0.000652881601948	0.416666666667	POLR2B POLR2J ELOA POLR2I CTDP1 SUPT5H SUPT4H1 LMO2 POLR2D POLR2G	Generic Transcription Pathway
GO:0140535	0.00107294610428	0.458333333333	POLR2B POLR2J PAF1 CTR9 POLR2J2 POLR2I LEO1 SKIC8 CDC73 POLR2D POLR2G	intracellular protein-containing complex
HPA:0630222	0.00107763340652	0.666666666667	CTDP1 POLR2B SUPT6H SUPT5H ELOA CDC73 POLR2D POLR2G IWS1 CTR9 ASB6 LEO1 RPRD1A RPRD1B RPRD2 SKIC8	cervix; squamous epithelial cells[>=Medium]
REAC:R-HSA-168255	0.00108437096859	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Influenza Infection
HPA:0470681	0.00145061864716	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	skin 2; epidermal cells[>=Low]
REAC:R-HSA-5663205	0.00147839868247	0.375	POLR2B POLR2J SUPT4H1 POLR2I CTDP1 SUPT5H ELOA POLR2D POLR2G	Infectious disease
CORUM:810	0.00163642570415	0.0833333333333	POLR2B CTDP1	FCP1-associated protein complex
CORUM:811	0.00163642570415	0.0833333333333	POLR2B CTDP1	FCP1-associated protein complex
GO:0032786	0.00165567048162	0.208333333333	SUPT4H1 LEO1 CDC73 SUPT6H SUPT5H	positive regulation of DNA-templated transcription, elongation
GO:0044249	0.00168315621009	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	cellular biosynthetic process
HPA:0460641	0.00189011346059	0.666666666667	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G POLR2D SKIC8	skin 1; Langerhans[>=Low]
GO:1901576	0.00199545851501	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	organic substance biosynthetic process
GO:0009058	0.00226494318554	0.916666666667	PAF1 SUPT4H1 POLR2I RECQL5 POLR2D SUPT6H ELOA CTDP1 RPAP2 RPRD1B CTR9 LEO1 POLR2B IWS1 RPRD1A LMO2 POLR2G POLR2J CDC73 SUPT5H SKIC8 RPRD2	biosynthetic process
GO:0045638	0.00252600260111	0.208333333333	PAF1 LEO1 CTR9 CDC73 SKIC8	negative regulation of myeloid cell differentiation
HPA:0440000	0.00272137420945	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	skeletal muscle
HPA:0440341	0.00272137420945	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	skeletal muscle; myocytes[>=Low]
REAC:R-HSA-8939211	0.0032226028188	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	ESR-mediated signaling
GO:0031442	0.00387837112504	0.125	LEO1 CDC73 PAF1	positive regulation of mRNA 3'-end processing
WP:WP2853	0.00438841702849	0.166666666667	LEO1 CTR9 CDC73 PAF1	Endoderm differentiation
REAC:R-HSA-72163	0.00481564284748	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	mRNA Splicing - Major Pathway
GO:0003899	0.00557617415587	0.166666666667	POLR2B POLR2I POLR2J2 POLR2J	DNA-directed 5'-3' RNA polymerase activity
REAC:R-HSA-72172	0.00568086838102	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	mRNA Splicing
GO:0097747	0.00744715310433	0.166666666667	POLR2B POLR2I POLR2J2 POLR2J	RNA polymerase activity
GO:0034062	0.00744715310433	0.166666666667	POLR2B POLR2I POLR2J2 POLR2J	5'-3' RNA polymerase activity
HPA:0590052	0.00985748154543	0.75	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	thyroid gland; glandular cells[>=Medium]
HPA:0540052	0.0101809151012	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	stomach 1; glandular cells[>=Medium]
HPA:0090191	0.0112666771389	0.666666666667	PAF1 LMO2 SUPT5H SUPT6H RPAP2 ELOA CDC73 CTDP1 POLR2G IWS1 CTR9 ASB6 LEO1 RPRD1A RPRD1B SKIC8	cerebellum; cells in molecular layer[>=Low]
HPA:0050091	0.0114469984737	0.75	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 CTDP1 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G POLR2D SKIC8	breast; myoepithelial cells[>=Low]
HPA:0180052	0.0118267475256	0.75	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	epididymis; glandular cells[>=Medium]
HPA:0460661	0.0125539143684	0.708333333333	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CTDP1 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G POLR2D SKIC8	skin 1; keratinocytes[>=Low]
REAC:R-HSA-9006931	0.0129553737284	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Signaling by Nuclear Receptors
HPA:0040081	0.0132132763684	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	bone marrow; hematopoietic cells[>=Low]
HPA:0040000	0.0132132763684	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	bone marrow
GO:0035987	0.0141507730701	0.166666666667	LEO1 CTR9 CDC73 PAF1	endodermal cell differentiation
HPA:0460651	0.0156006921142	0.625	POLR2B LMO2 SUPT6H SUPT5H ELOA CTDP1 POLR2G RPAP2 CTR9 ASB6 LEO1 RPRD1A RPRD1B POLR2D SKIC8	skin 1; fibroblasts[>=Low]
GO:0001055	0.0162365457737	0.125	POLR2B POLR2J POLR2J2	RNA polymerase II activity
HPA:0620222	0.0185530266937	0.625	POLR2B SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G SKIC8	vagina; squamous epithelial cells[>=Medium]
HPA:0460642	0.0196575128701	0.5	POLR2B SUPT6H PAF1 ELOA POLR2G SUPT5H CTR9 ASB6 LEO1 RPRD1A RPRD1B SKIC8	skin 1; Langerhans[>=Medium]
REAC:R-HSA-72203	0.0212163415551	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	Processing of Capped Intron-Containing Pre-mRNA
HPA:0090162	0.0217068329775	0.625	PAF1 LMO2 SUPT6H SUPT5H ELOA CDC73 CTDP1 POLR2G RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2D SKIC8	cerebellum; Purkinje cells[>=Medium]
GO:0001706	0.0245640023114	0.166666666667	LEO1 CTR9 CDC73 PAF1	endoderm formation
REAC:R-HSA-8953854	0.0245734676069	0.291666666667	POLR2B POLR2J POLR2I SUPT5H SKIC8 POLR2D POLR2G	Metabolism of RNA
HPA:0500651	0.0299650394216	0.625	POLR2B SUPT5H SUPT6H IWS1 ELOA CDC73 CTDP1 POLR2G RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2D SKIC8	soft tissue 1; fibroblasts[>=Low]
HPA:0630221	0.0321869428293	0.708333333333	CTDP1 POLR2B LMO2 SUPT6H SUPT5H ELOA CDC73 POLR2D POLR2G IWS1 CTR9 ASB6 LEO1 RPRD1A RPRD1B RPRD2 SKIC8	cervix; squamous epithelial cells[>=Low]
GO:0007492	0.0330615109471	0.166666666667	LEO1 CTR9 CDC73 PAF1	endoderm development
GO:0050684	0.0331534764394	0.208333333333	PAF1 IWS1 CDC73 SUPT6H LEO1	regulation of mRNA processing
HPA:0460662	0.0353806522298	0.541666666667	POLR2B RPRD1B SUPT6H SUPT5H ELOA PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G SKIC8	skin 1; keratinocytes[>=Medium]
REAC:R-HSA-73894	0.0357287527582	0.208333333333	POLR2D POLR2B POLR2G POLR2I POLR2J	DNA Repair
HPA:0420000	0.036334702062	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	salivary gland
HPA:0420051	0.036334702062	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	salivary gland; glandular cells[>=Low]
HPA:0100121	0.0370378670028	0.666666666667	POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CDC73 CTDP1 PAF1 RPAP2 CTR9 RPRD1B LEO1 RPRD1A POLR2G SKIC8	cerebral cortex; glial cells[>=Low]
HPA:0250131	0.0383391955505	0.75	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 CTDP1 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	hippocampus; neuronal cells[>=Low]
HPA:0090161	0.0399699676697	0.708333333333	PAF1 LMO2 SUPT5H SUPT6H RPAP2 ELOA CDC73 CTDP1 POLR2G IWS1 CTR9 ASB6 LEO1 RPRD1A RPRD1B POLR2D SKIC8	cerebellum; Purkinje cells[>=Low]
HPA:0630000	0.0406808048146	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	cervix
HPA:0350471	0.0412036443761	0.791666666667	CTDP1 POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	pancreas; exocrine glandular cells[>=Low]
GO:0031440	0.0423869429414	0.125	LEO1 CDC73 PAF1	regulation of mRNA 3'-end processing
HPA:0100132	0.0453095071352	0.666666666667	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G SKIC8	cerebral cortex; neuronal cells[>=Medium]
HPA:0330000	0.0475000581438	0.75	CTDP1 POLR2B SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	oral mucosa
HPA:0330221	0.0475000581438	0.75	CTDP1 POLR2B SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 POLR2D PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G RPRD2 SKIC8	oral mucosa; squamous epithelial cells[>=Low]
HPA:0600222	0.0477231007219	0.666666666667	POLR2B LMO2 SUPT5H SUPT6H IWS1 ELOA CDC73 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A RPRD1B RPRD2 POLR2G	tonsil; squamous epithelial cells[>=Medium]
HPA:0130201	0.0496835835266	0.708333333333	POLR2B LMO2 SUPT5H SUPT6H RPRD1B IWS1 ELOA CDC73 PAF1 RPAP2 CTR9 ASB6 LEO1 RPRD1A POLR2G POLR2D SKIC8	colon; endothelial cells[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PAF1	CDC73	1.0	0.814
SKIC8	LEO1	1.0	0.186
PAF1	CTR9	1.0	0.932	structurally_consistent (dimer)
POLR2D	POLR2B	1.0	0.908	structurally_consistent (dimer)
POLR2G	POLR2C	1.0	0.742
CTR9	CDC73	1.0	0.786	structurally_consistent (dimer)
LEO1	PAF1	1.0	0.95
POLR2G	POLR2D	1.0	0.83	structurally_consistent (dimer)
SKIC8	CTR9	1.0	0.192	structurally_consistent (dimer)
POLR2I	RPRD1B	1.0	0.172	structurally_consistent (P30876)
POLR2D	POLR2I	1.0	0.63
RPRD1A	RPRD1B	1.0	0.512	structurally_consistent (dimer)
SKIC8	PAF1	1.0	0.264	structurally_consistent (dimer)
POLR2D	RPRD1B	1.0	0.112	structurally_consistent (dimer)
LEO1	CTR9	1.0	0.808	structurally_consistent (dimer)
POLR2G	RPAP2	1.0	0.096	structurally_consistent (P19388)
POLR2C	POLR2D	1.0	0.9	structurally_consistent (P30876)
POLR2C	RPRD1B	1.0	0.434	structurally_consistent (P30876) structurally_consistent (dimer)
RPRD1B	POLR2J	1.0	0.122
POLR2C	POLR2J	1.0	0.898
POLR2G	RPRD1B	1.0	0.394	structurally_consistent (dimer)
POLR2I	POLR2B	1.0	0.4679375	structurally_consistent (dimer)
POLR2G	RECQL5	1.0	0.08	structurally_consistent (dimer)
SKIC8	CDC73	1.0	0.136
LEO1	CDC73	1.0	0.666
RECQL5	RPRD1B	1.0	0.034
POLR2C	POLR2I	1.0	0.462	structurally_consistent (P30876)
POLR2G	POLR2I	1.0	0.422
POLR2C	POLR2B	1.0	0.866	structurally_consistent (dimer)
POLR2B	POLR2J	1.0	0.786
POLR2D	RPAP2	1.0	0.124
POLR2G	POLR2B	0.999	0.704	structurally_consistent (dimer)
POLR2D	POLR2J	0.999	0.9
RPAP2	POLR2J	0.999	0.104
RECQL5	POLR2J	0.999	0.052
POLR2D	RPRD1A	0.999	0.14	mutually_exclusive (P62487)
RPRD2	RPRD1B	0.999	0.122	mutually_exclusive (Q96P16) structurally_consistent (dimer)
POLR2I	RPAP2	0.999	0.106
RPRD1B	RPAP2	0.999	0.062
RECQL5	POLR2I	0.999	0.04
RPRD1B	POLR2B	0.999	0.199333333333	structurally_consistent (dimer)
POLR2G	POLR2J	0.999	0.7
SUPT6H	RPRD1B	0.999	0.142
RECQL5	RPAP2	0.999	0.068
POLR2C	RPAP2	0.999	0.132
POLR2G	RPRD1A	0.999	0.3	structurally_consistent (dimer)
LMO2	RECQL5	0.999
POLR2C	RECQL5	0.999	0.042
RPRD1A	RPAP2	0.999	0.082
POLR2D	SUPT6H	0.999	0.86
RPRD1A	POLR2I	0.999	0.234
RECQL5	POLR2B	0.998	0.172
RPRD1B	CTDP1	0.998	0.068
LMO2	RPAP2	0.998
POLR2G	POLR2J2	0.998
POLR2B	RPAP2	0.998	0.192
RPRD1A	POLR2J	0.998	0.07	structurally_consistent (Q9NWX5)
LMO2	POLR2C	0.998
POLR2G	LMO2	0.998		structurally_consistent (dimer)
LMO2	POLR2J	0.998
POLR2C	RPRD1A	0.998	0.276	mutually_exclusive (Q9NWX5)
RPRD1A	POLR2B	0.998	0.168
RPRD2	POLR2D	0.997	0.166
ASB6	POLR2C	0.997	0.154	structurally_consistent (dimer)
POLR2D	RECQL5	0.997	0.058
GTF2F2	POLR2G	0.997	0.228
LMO2	POLR2D	0.996		structurally_consistent (dimer)
ASB6	POLR2D	0.996	0.096
SUPT6H	POLR2J	0.996	0.46
POLR2J2	POLR2J	0.995
ASB6	POLR2J	0.995	0.104	structurally_consistent (dimer)
SUPT6H	POLR2B	0.995	0.698
POLR2I	POLR2J	0.994	0.344	structurally_consistent (dimer)
RPRD1A	SUPT6H	0.994	0.104
ELOA	IWS1	0.994	0.198
POLR2G	SUPT6H	0.993	0.386
ASB6	RPAP2	0.993	0.146
RPRD1A	RECQL5	0.993	0.07
POLR2G	SUPT5H	0.993	0.484	structurally_consistent (dimer)
LMO2	POLR2B	0.993		structurally_consistent (O15514)
POLR2G	CTDP1	0.992	0.108	structurally_consistent (dimer)
RPRD2	POLR2C	0.992	0.188
POLR2G	ELOA	0.992	0.086	structurally_consistent (P30876)
RPRD2	POLR2J	0.991	0.128
POLR2G	CDC73	0.99	0.17	mutually_exclusive (O15514) structurally_consistent (dimer)
POLR2J2	RPAP2	0.99
ASB6	POLR2B	0.99	0.26
POLR2G	RPRD2	0.989	0.156
RPRD2	RPRD1A	0.989	0.112	mutually_exclusive (Q9NQG5) structurally_consistent (dimer)
POLR2I	SUPT6H	0.988	0.594
RPRD2	POLR2B	0.988	0.248
POLR2C	POLR2J2	0.988
SUPT4H1	RPRD1B	0.986	0.098
LMO2	SUPT6H	0.986
POLR2C	SUPT6H	0.986	0.662
RPRD2	POLR2I	0.985	0.28
CTR9	ELOA	0.985	0.342
PAF1	POLR2G	0.984	0.242	mutually_exclusive (Q9GZS3) structurally_consistent (dimer)
LMO2	POLR2I	0.984
SUPT5H	SUPT4H1	0.983	0.738	structurally_consistent (dimer)
RPRD2	POLR2J2	0.983
POLR2J2	POLR2B	0.983
POLR2I	CTDP1	0.983	0.154
POLR2D	CDC73	0.983	0.568	mutually_exclusive (P62487) structurally_consistent (dimer)
POLR2C	CDC73	0.982	0.418
RPRD2	RPAP2	0.982	0.13
SKIC8	SUPT6H	0.981	0.218
RPRD2	SUPT6H	0.981	0.272
SUPT4H1	POLR2C	0.98	0.468
ASB6	RECQL5	0.978	0.05
SKIC8	POLR2C	0.978	0.4397	structurally_consistent (dimer)
SUPT5H	IWS1	0.978	0.452
POLR2G	SUPT4H1	0.977	0.356
POLR2D	POLR2J2	0.976
POLR2J2	RECQL5	0.976
SUPT6H	RPAP2	0.975	0.12
SKIC8	SUPT5H	0.975	0.224
GTF2F2	POLR2C	0.975	0.162	structurally_consistent (P30876)
CDC73	POLR2B	0.974	0.708
RECQL5	SUPT6H	0.973	0.160153846154
SUPT4H1	RPAP2	0.973	0.106
PAF1	SUPT5H	0.971	0.598
CTDP1	POLR2B	0.971	0.304	mutually_exclusive (P62487)
POLR2G	IWS1	0.97	0.302
POLR2J2	POLR2I	0.97
LEO1	POLR2C	0.969	0.334	structurally_consistent (P30876)
SUPT4H1	POLR2D	0.967	0.634
RPRD1A	CTDP1	0.967	0.094	mutually_exclusive (P62487)
POLR2C	ELOA	0.967	0.144	structurally_consistent (P30876)
POLR2G	ASB6	0.966	0.112
GTF2F2	POLR2I	0.966	0.182	structurally_consistent (P30876)
SUPT5H	RPRD2	0.966	0.172
LMO2	RPRD1B	0.965
LEO1	POLR2G	0.965	0.35
SKIC8	POLR2G	0.964	0.392	structurally_consistent (dimer)
SUPT5H	POLR2B	0.963	0.638
POLR2C	IWS1	0.962	0.394
RPRD2	RECQL5	0.959	0.036
CTR9	IWS1	0.958	0.38	mutually_exclusive (Q9GZS3)
ASB6	POLR2I	0.956	0.174
RECQL5	CTDP1	0.956	0.05
SUPT4H1	SUPT6H	0.956	0.278
SUPT6H	IWS1	0.952	0.256
CDC73	ELOA	0.951	0.336
PAF1	RPAP2	0.948	0.126
POLR2C	CTDP1	0.948	0.162
SUPT5H	CTDP1	0.947	0.274	mutually_exclusive (P62487)
SUPT5H	POLR2C	0.946	0.548
LEO1	RPRD2	0.943	0.224
SKIC8	ELOA	0.943	0.108
SUPT4H1	IWS1	0.936	0.216
RPRD1A	POLR2J2	0.936
PAF1	IWS1	0.935	0.302	mutually_exclusive (Q9GZS3)
POLR2J2	RPRD1B	0.933
RPRD2	CDC73	0.931	0.264
SUPT5H	SUPT6H	0.929	0.498
CDC73	IWS1	0.926	0.286
CTDP1	POLR2J	0.925	0.102
POLR2I	CDC73	0.924	0.408
PAF1	POLR2C	0.921	0.566
SUPT4H1	POLR2B	0.916	0.45
SKIC8	RPRD2	0.915	0.066
RPRD2	CTR9	0.912	0.154
SUPT5H	RPAP2	0.898	0.14
LMO2	RPRD1A	0.897
POLR2G	CTR9	0.888	0.306
PAF1	POLR2D	0.882	0.586	mutually_exclusive (P62487)
PAF1	ELOA	0.881	0.298
GTF2F2	CTDP1	0.88	0.124	mutually_exclusive (P52434)
RPRD2	CTDP1	0.873	0.136
SUPT4H1	CDC73	0.869	0.282
SUPT5H	CTR9	0.867	0.614
SKIC8	POLR2B	0.864	0.548	structurally_consistent (P19387)
POLR2D	ELOA	0.864	0.168	structurally_consistent (P30876)
CTDP1	RPAP2	0.861	0.204
PAF1	RPRD1A	0.858	0.204
SKIC8	SUPT4H1	0.857	0.236	structurally_consistent (dimer)
SUPT5H	ELOA	0.856	0.29
LEO1	ELOA	0.853	0.22	mutually_exclusive (P30876)
POLR2C	CTR9	0.85	0.41
SUPT5H	CDC73	0.849	0.382
POLR2D	CTDP1	0.849	0.196	mutually_exclusive (P62487)
RPRD1A	CDC73	0.839	0.13
PAF1	SUPT6H	0.837	0.516
PAF1	SUPT4H1	0.835	0.208
SUPT4H1	RPRD2	0.833	0.108
RPRD1A	CTR9	0.828	0.102
GTF2F2	RPAP2	0.815	0.192
RPRD2	ELOA	0.806	0.082
ASB6	RPRD1A	0.805	0.06	structurally_consistent (dimer)
GTF2F2	SUPT5H	0.804	0.338
GTF2F2	RECQL5	0.803	0.062
GTF2F2	POLR2J2	0.796
POLR2J2	CTDP1	0.796
RPRD1B	IWS1	0.791	0.146
SUPT5H	RECQL5	0.79	0.062
LEO1	POLR2D	0.79	0.484	structurally_consistent (P30876)
CDC73	RPAP2	0.79	0.168
LEO1	RPRD1B	0.779	0.082
SUPT5H	RPRD1B	0.774	0.176	structurally_consistent (P62487)
SUPT5H	POLR2D	0.772	0.662
LMO2	RPRD2	0.769
SKIC8	IWS1	0.757	0.206	structurally_consistent (dimer)
LEO1	SUPT5H	0.754	0.604
SUPT4H1	CTR9	0.744	0.198
SUPT6H	CTDP1	0.707	0.238
LEO1	IWS1	0.702	0.236
LEO1	SUPT4H1	0.694	0.32
PAF1	POLR2I	0.684	0.266
PAF1	RPRD2	0.678	0.278
SKIC8	RPRD1A	0.643	0.15
POLR2D	CTR9	0.641	0.46
POLR2D	IWS1	0.635	0.494
GTF2F2	POLR2B	0.594	0.472	structurally_consistent (dimer)
SUPT5H	POLR2I	0.582	0.314
SUPT6H	CTR9	0.57	0.388
RPRD2	IWS1	0.568	0.174
GTF2F2	IWS1	0.562	0.156	mutually_exclusive (Q9GZS3)
SKIC8	POLR2D	0.558	0.586
PAF1	POLR2B	0.524	0.618
POLR2B	IWS1	0.511	0.456
SKIC8	RPAP2	0.507	0.164
POLR2J2	SUPT6H	0.499
CTR9	POLR2B	0.479	0.546
LEO1	POLR2B	0.478	0.402	structurally_consistent (dimer)
SUPT6H	CDC73	0.473	0.32
LEO1	SUPT6H	0.449	0.424
SUPT6H	ELOA	0.391	0.09
SUPT4H1	POLR2I	0.388	0.356
POLR2J2	IWS1	0.351
PAF1	POLR2J2	0.351
PAF1	RPRD1B	0.332	0.102
SUPT4H1	RPRD1A	0.328	0.23
RPRD1B	CDC73	0.284	0.096
GTF2F2	POLR2D	0.257	0.392	structurally_consistent (P30876)
GTF2F2	POLR2J	0.23	0.23
RPRD1B	CTR9	0.227	0.056
SUPT5H	POLR2J2	0.226
POLR2J2	CDC73	0.218
ASB6	SUPT6H	0.193	0.128
LEO1	RPRD1A	0.192	0.054
SUPT4H1	POLR2J2	0.192
ASB6	CTDP1	0.188	0.048
IWS1	POLR2J	0.186	0.48
ELOA	POLR2B	0.177	0.246	structurally_consistent (dimer)
SKIC8	POLR2I	0.169	0.566
SKIC8	RPRD1B	0.168	0.114	structurally_consistent (P62487)
SUPT5H	POLR2J	0.168	0.556
PAF1	POLR2J	0.164	0.404
GTF2F2	CDC73	0.161	0.416
ELOA	POLR2J	0.153	0.092
CTDP1	CDC73	0.147	0.132	mutually_exclusive (P62487)
SUPT4H1	POLR2J	0.147	0.6
PAF1	CTDP1	0.142	0.176	mutually_exclusive (P62487)
GTF2F2	ELOA	0.142	0.256	mutually_exclusive (P30876)
RPAP2	IWS1	0.139	0.094
RPRD1A	IWS1	0.112	0.138
ASB6	RPRD1B	0.1	0.088
CDC73	POLR2J	0.088	0.12
ELOA	RPAP2	0.081	0.162
SUPT4H1	CTDP1	0.081	0.1
CTDP1	CTR9	0.077	0.17
PAF1	RECQL5	0.068	0.074
GTF2F2	SUPT4H1	0.068	0.432
RECQL5	CDC73	0.065	0.166
SKIC8	POLR2J2	0.063
LEO1	POLR2J2	0.063
SKIC8	CTDP1	0.06	0.102	mutually_exclusive (P62487)
LEO1	POLR2I	0.059	0.282	structurally_consistent (P30876)
CTR9	RPAP2	0.053	0.126
SKIC8	POLR2J	0.053	0.428
CTDP1	IWS1	0.052	0.15
POLR2J2	CTR9	0.049
POLR2I	ELOA	0.049	0.118
LEO1	RPAP2	0.047	0.176
GTF2F2	PAF1	0.045	0.384
POLR2I	CTR9	0.039	0.298
GTF2F2	RPRD1B	0.037	0.118	structurally_consistent (P30876)
GTF2F2	SUPT6H	0.034	0.436
GTF2F2	RPRD2	0.03	0.092
SUPT4H1	ELOA	0.028	0.11
SUPT5H	RPRD1A	0.027	0.322
CTR9	POLR2J	0.027	0.262
POLR2I	IWS1	0.027	0.229333333333
SUPT4H1	RECQL5	0.024	0.086
RECQL5	CTR9	0.023	0.13
LEO1	RECQL5	0.023	0.058
GTF2F2	CTR9	0.023	0.478
GTF2F2	SKIC8	0.019	0.366	mutually_exclusive (P52434) structurally_consistent (dimer)
LEO1	POLR2J	0.019	0.356
GTF2F2	LEO1	0.016	0.334	structurally_consistent (dimer)
LEO1	CTDP1	0.016	0.068
GTF2F2	RPRD1A	0.016	0.142
ASB6	RPRD2	0.016	0.108
RECQL5	ELOA	0.015	0.076
CTDP1	ELOA	0.015	0.126
RPRD1B	ELOA	0.007	0.03	structurally_consistent (P30876)
SKIC8	LMO2	0.007
SKIC8	RECQL5	0.006	0.11
SKIC8	ASB6	0.004	0.076

Related Complexes

Genename	Complexes
RPRD1A	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
POLR2B	huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
POLR2I	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_13730.1 huMAP3_14318.1
SUPT6H	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
RPAP2	huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
IWS1	huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
OR4K3	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
ASB6	huMAP3_03422.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_12130.1 huMAP3_14318.1
LEO1	huMAP3_01529.1 huMAP3_02343.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
ELOA	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
SKIC8	huMAP3_01232.1 huMAP3_01529.1 huMAP3_02343.1 huMAP3_03766.1 huMAP3_06456.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_10359.1 huMAP3_11018.1 huMAP3_11037.1 huMAP3_11092.1 huMAP3_12111.1
POLR2J	huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
POLR2J2	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
RECQL5	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
RPRD2	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_12111.1 huMAP3_14318.1
SUPT5H	huMAP3_02594.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
GTF2F2	huMAP3_00159.1 huMAP3_02594.1 huMAP3_04078.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_10292.1 huMAP3_11018.1 huMAP3_11092.1
LMO2	huMAP3_04419.1 huMAP3_04499.1 huMAP3_07288.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07979.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1 huMAP3_14640.1
SUPT4H1	huMAP3_03952.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1 huMAP3_14318.1 huMAP3_14483.1
PAF1	huMAP3_01529.1 huMAP3_02343.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
CDC73	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
POLR2C	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
POLR2D	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
CTR9	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
POLR2G	huMAP3_02594.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1 huMAP3_14318.1
CTDP1	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1
RPRD1B	huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_11092.1 huMAP3_14318.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07454.1

Complex Portal: CPX-25516