hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07457.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt NCBI |
| APLF | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 2.80233355908e-09 | 0.6 | POLB PNKP LIG3 | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| KEGG:03410 | 1.57296490579e-08 | 0.8 | POLB LIG3 PNKP APTX | Base excision repair |
| REAC:R-HSA-5649702 | 1.09182472013e-07 | 0.6 | POLB PNKP LIG3 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| WP:WP4752 | 4.88902625878e-06 | 0.6 | POLB PNKP LIG3 | Base excision repair |
| REAC:R-HSA-73933 | 2.03584684634e-05 | 0.6 | POLB PNKP LIG3 | Resolution of Abasic Sites (AP sites) |
| CORUM:5243 | 4.09448956317e-05 | 0.4 | PNKP LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:1086 | 8.18785830799e-05 | 0.4 | POLB LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| CORUM:1085 | 8.18785830799e-05 | 0.4 | POLB LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-110381 | 9.11829675208e-05 | 0.4 | POLB LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| REAC:R-HSA-73884 | 0.000217750033404 | 0.6 | POLB PNKP LIG3 | Base Excision Repair |
| GO:0006266 | 0.000274621184043 | 0.6 | APLF PNKP LIG3 | DNA ligation |
| GO:0006287 | 0.000274621184043 | 0.6 | POLB PNKP LIG3 | base-excision repair, gap-filling |
| WP:WP4946 | 0.00027954510039 | 0.6 | POLB PNKP LIG3 | DNA repair pathways full network |
| GO:0006281 | 0.00195208595796 | 1.0 | APTX POLB LIG3 PNKP APLF | DNA repair |
| GO:0140097 | 0.00729542990987 | 0.8 | POLB LIG3 APTX APLF | catalytic activity, acting on DNA |
| GO:0006284 | 0.0094606249379 | 0.6 | POLB PNKP LIG3 | base-excision repair |
| HP:0003387 | 0.00979150178217 | 0.4 | APTX LIG3 | Decreased number of large peripheral myelinated nerve fibers |
| GO:0006974 | 0.0141199763351 | 1.0 | APTX POLB LIG3 PNKP APLF | DNA damage response |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | POLB PNKP LIG3 | DNA Repair |
| GO:0006259 | 0.0192772113985 | 1.0 | APTX POLB LIG3 PNKP APLF | DNA metabolic process |
| GO:0006303 | 0.0211358171848 | 0.6 | POLB PNKP APLF | double-strand break repair via nonhomologous end joining |
| GO:0006302 | 0.0280745884658 | 0.8 | POLB LIG3 PNKP APLF | double-strand break repair |
| GO:0051103 | 0.0280843539964 | 0.4 | PNKP LIG3 | DNA ligation involved in DNA repair |
| HP:0003380 | 0.0497672375822 | 0.4 | APTX LIG3 | Decreased number of peripheral myelinated nerve fibers |
| CORUM:212 | 0.0498708842806 | 0.2 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 0.0498708842806 | 0.2 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 0.0498708842806 | 0.2 | LIG3 | DNA ligase III-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LIG3 | XRCC1 | 1.0 | 0.55 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| POLB | XRCC1 | 0.999 | 0.084 |
mutually_exclusive (P35244)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| LIG3 | POLB | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIG3 | PNKP | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LIG3 | APTX | 0.997 | 0.136 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLF | LIG3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PNKP | POLB | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | XRCC1 | 0.993 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| APLF | POLB | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APLF | XRCC1 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| POLB | APTX | 0.99 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | APTX | 0.958 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | APTX | 0.951 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| APLF | APTX | 0.353 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APLF | PNKP | 0.297 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes