hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07459.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZMYND8 | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | 5 | UniProt NCBI |
| ZNF687 | Zinc finger protein 687 | 5 | UniProt NCBI |
| CDK2AP1 | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | 5 | UniProt NCBI |
| ZNF592 | Zinc finger protein 592 | 4 | UniProt NCBI |
| GATAD2A | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | 5 | UniProt NCBI |
| MBD2 | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | 5 | UniProt NCBI |
| MBD3 | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:649 | 5.89237886406e-07 | 0.428571428571 | MBD2 GATAD2A MBD3 | HDAC1-associated core complex cII |
| GO:0016581 | 1.25481586619e-06 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | NuRD complex |
| GO:0090545 | 1.25481586619e-06 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | CHD-type complex |
| KEGG:03082 | 4.34806074029e-06 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | ATP-dependent chromatin remodeling |
| CORUM:650 | 0.000430566012817 | 0.285714285714 | MBD3 GATAD2A | HDAC2-asscociated core complex |
| CORUM:62 | 0.000573957048441 | 0.285714285714 | MBD2 MBD3 | MeCP1 complex |
| GO:0000118 | 0.000579396940492 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | histone deacetylase complex |
| CORUM:685 | 0.000737776422886 | 0.285714285714 | MBD2 MBD3 | MeCP1 complex |
| CORUM:659 | 0.000737776422886 | 0.285714285714 | MBD2 MBD3 | MeCP1 complex |
| CORUM:646 | 0.000737776422886 | 0.285714285714 | MBD2 MBD3 | HDAC1-associated protein complex |
| REAC:R-HSA-73854 | 0.0019448769621 | 0.428571428571 | MBD2 GATAD2A MBD3 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 0.00200524097522 | 0.428571428571 | MBD2 GATAD2A MBD3 | RNA Polymerase I Transcription |
| CORUM:282 | 0.00245532971616 | 0.285714285714 | MBD2 MBD3 | SNF2h-cohesin-NuRD complex |
| GO:0070603 | 0.002536243155 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | SWI/SNF superfamily-type complex |
| CORUM:778 | 0.00349645023665 | 0.285714285714 | MBD2 MBD3 | LARC complex (LCR-associated remodeling complex) |
| REAC:R-HSA-212165 | 0.0103135924507 | 0.428571428571 | MBD2 GATAD2A MBD3 | Epigenetic regulation of gene expression |
| WP:WP4320 | 0.0117684016707 | 0.285714285714 | MBD2 MBD3 | Effect of progerin on genes involved in Hutchinson Gilford progeria syndrome |
| GO:1904949 | 0.0134125272986 | 0.571428571429 | MBD3 MBD2 CDK2AP1 GATAD2A | ATPase complex |
| REAC:R-HSA-6804758 | 0.0164719839916 | 0.285714285714 | MBD3 GATAD2A | Regulation of TP53 Activity through Acetylation |
| HPA:0090182 | 0.0203907601067 | 0.857142857143 | ZNF592 GATAD2A ZMYND8 MBD3 CDK2AP1 ZNF687 | cerebellum; cells in granular layer[>=Medium] |
| HPA:0380511 | 0.0208100036051 | 1.0 | ZNF592 GATAD2A MBD2 ZMYND8 MBD3 CDK2AP1 ZNF687 | placenta; decidual cells[>=Low] |
| HPA:0530711 | 0.0384192144898 | 1.0 | ZNF592 GATAD2A MBD2 ZMYND8 MBD3 CDK2AP1 ZNF687 | spleen; cells in red pulp[>=Low] |
| REAC:R-HSA-73762 | 0.0407752524289 | 0.285714285714 | MBD3 GATAD2A | RNA Polymerase I Transcription Initiation |
| HPA:0490691 | 0.0470701914608 | 1.0 | ZNF592 GATAD2A MBD2 ZMYND8 MBD3 CDK2AP1 ZNF687 | smooth muscle; smooth muscle cells[>=Low] |
| HPA:0490000 | 0.0470701914608 | 1.0 | ZNF592 GATAD2A MBD2 ZMYND8 MBD3 CDK2AP1 ZNF687 | smooth muscle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MBD3 | CDK2AP1 | 1.0 | 0.074 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| GATAD2A | CDK2AP1 | 1.0 | 0.198 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| GATAD2A | MBD3 | 1.0 | 0.448 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| CDK2AP1 | MBD2 | 1.0 | 0.108 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| GATAD2A | MBD2 | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| ZNF687 | ZNF592 | 0.999 | 0.25 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZMYND8 | ZNF687 | 0.999 | 0.424 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| MBD3 | MBD2 | 0.999 | 0.042 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| ZMYND8 | ZNF592 | 0.998 | 0.272 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF687 | GATAD2A | 0.997 | 0.162 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZNF687 | CDK2AP1 | 0.995 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZNF592 | GATAD2A | 0.992 | 0.332 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| ZMYND8 | CDK2AP1 | 0.992 | 0.338 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZMYND8 | GATAD2A | 0.99 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| ZNF687 | MBD3 | 0.989 | 0.048 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF592 | MBD2 | 0.989 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF687 | MBD2 | 0.984 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZMYND8 | MBD2 | 0.982 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF592 | MBD3 | 0.968 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ZMYND8 | MBD3 | 0.953 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ZNF592 | CDK2AP1 | 0.877 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes