hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07479.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KPNA4 | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | 5 | UniProt NCBI |
| KPNA3 | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | 5 | UniProt NCBI |
| KPNA2 | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | 5 | UniProt NCBI |
| KIFC1 | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | 5 | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | 5 | UniProt NCBI |
| KPNB1 | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168276 | 8.64225650575e-11 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-1169408 | 1.7689324393e-09 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 2.76846766863e-09 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Antiviral mechanism by IFN-stimulated genes |
| KEGG:03013 | 4.40572102528e-09 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Nucleocytoplasmic transport |
| GO:0042564 | 4.97036464355e-08 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | NLS-dependent protein nuclear import complex |
| REAC:R-HSA-168255 | 1.08883227368e-07 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Influenza Infection |
| GO:0031074 | 1.30147699894e-07 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | nucleocytoplasmic transport complex |
| REAC:R-HSA-913531 | 2.53969571779e-07 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Interferon Signaling |
| GO:0061608 | 7.17391174374e-07 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | nuclear import signal receptor activity |
| GO:0006607 | 1.20589885889e-06 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | NLS-bearing protein import into nucleus |
| GO:0008139 | 2.88146527749e-06 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | nuclear localization sequence binding |
| GO:0006606 | 4.94034321414e-06 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | protein import into nucleus |
| GO:0051170 | 6.27436281495e-06 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | import into nucleus |
| GO:0140142 | 6.90936487191e-06 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | nucleocytoplasmic carrier activity |
| KEGG:05207 | 1.13794685426e-05 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | Chemical carcinogenesis - receptor activation |
| CORUM:6142 | 1.70876175213e-05 | 0.333333333333 | KPNA2 KPNB1 | KPNA2-KPNB1 complex |
| GO:0005048 | 3.23392996598e-05 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | signal sequence binding |
| HPA:0570782 | 4.01345057901e-05 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | testis; preleptotene spermatocytes[>=Medium] |
| REAC:R-HSA-1280215 | 0.000131694364092 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Cytokine Signaling in Immune system |
| HPA:0570781 | 0.000169334994008 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | testis; preleptotene spermatocytes[>=Low] |
| GO:0034504 | 0.000229131033887 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | protein localization to nucleus |
| REAC:R-HSA-9824446 | 0.000269027682904 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Viral Infection Pathways |
| GO:0006913 | 0.000353616039768 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | nucleocytoplasmic transport |
| GO:0051169 | 0.000353616039768 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | nuclear transport |
| GO:0140104 | 0.000619048899658 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | molecular carrier activity |
| HPA:0570761 | 0.000652536754115 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | testis; pachytene spermatocytes[>=Low] |
| GO:0005643 | 0.000719028723342 | 0.666666666667 | NUP50 KPNB1 KPNA4 KPNA3 | nuclear pore |
| REAC:R-HSA-5663205 | 0.000749154054491 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Infectious disease |
| HPA:0570812 | 0.00110302119642 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | testis; spermatogonia cells[>=Medium] |
| GO:0072594 | 0.00191955787119 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | establishment of protein localization to organelle |
| GO:0005635 | 0.00228495154828 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | nuclear envelope |
| HPA:0570811 | 0.0030461686448 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | testis; spermatogonia cells[>=Low] |
| REAC:R-HSA-168271 | 0.0104313293282 | 0.333333333333 | NUP50 KPNB1 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-1643685 | 0.0108707096527 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Disease |
| GO:0006886 | 0.0115105095905 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | intracellular protein transport |
| REAC:R-HSA-180746 | 0.0119428487471 | 0.333333333333 | NUP50 KPNB1 | Nuclear import of Rev protein |
| REAC:R-HSA-177243 | 0.0144005758041 | 0.333333333333 | NUP50 KPNB1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-9692916 | 0.0180324600743 | 0.333333333333 | KPNA2 KPNB1 | SARS-CoV-1 activates/modulates innate immune responses |
| REAC:R-HSA-168256 | 0.0203260039291 | 0.833333333333 | KPNA2 KPNB1 NUP50 KPNA4 KPNA3 | Immune System |
| GO:0031965 | 0.0270492850378 | 0.666666666667 | KPNA2 KPNB1 KPNA4 NUP50 | nuclear membrane |
| GO:0042277 | 0.0303803653312 | 0.666666666667 | KPNA2 KPNB1 KPNA4 KPNA3 | peptide binding |
| GO:0051649 | 0.0361725108126 | 1.0 | KPNB1 KPNA4 KIFC1 NUP50 KPNA2 KPNA3 | establishment of localization in cell |
| HPA:0090963 | 0.0369985685664 | 0.333333333333 | KPNB1 KPNA4 | cerebellum; Purkinje cells - nucleus[High] |
| CORUM:7543 | 0.0499436884912 | 0.166666666667 | KPNB1 | KPNB1-SMN-SPN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KPNA2 | NUP50 | 1.0 | 0.184 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| KPNB1 | KPNA2 | 0.999 | 0.26 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| KIFC1 | NUP50 | 0.999 | 0.062 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| KPNA3 | NUP50 | 0.999 | 0.248 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| KPNA3 | KPNA4 | 0.999 | 0.44 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KPNB1 | NUP50 | 0.999 | 0.306 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KPNA4 | NUP50 | 0.997 | 0.178 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| KPNA3 | KPNA2 | 0.996 | 0.198 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| KPNA2 | KPNA4 | 0.996 | 0.182545454545 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| KPNA3 | KIFC1 | 0.995 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| KIFC1 | KPNA4 | 0.995 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| KPNA2 | KIFC1 | 0.993 | 0.236051282051 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| KPNB1 | KIFC1 | 0.983 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| KPNB1 | KPNA4 | 0.982 | 0.656 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction |
| KPNB1 | KPNA3 | 0.981 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction treiber_WMM |
Related Complexes