hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07481.1

Complex Portal: CPX-21163

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
RPAIN	RPA-interacting protein (hRIP)	5	UniProt NCBI
RPA4	Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)	5	UniProt NCBI
MACROD1	ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)	5	UniProt NCBI
RPA2	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	5	UniProt NCBI
RPA3	Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)	5	UniProt NCBI
HMCES	Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)	5	UniProt NCBI
RPA1	Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03430	3.51355883349e-06	0.5	RPA1 RPA4 RPA3	Mismatch repair
KEGG:03030	1.41369735506e-05	0.5	RPA1 RPA4 RPA3	DNA replication
CORUM:5229	1.70876175213e-05	0.333333333333	RPA3 RPA1	RPA complex
KEGG:03440	1.95500220111e-05	0.5	RPA1 RPA4 RPA3	Homologous recombination
WP:WP466	3.14733202476e-05	0.5	RPA1 RPA4 RPA3	DNA replication
KEGG:03460	3.64058537011e-05	0.5	RPA1 RPA4 RPA3	Fanconi anemia pathway
REAC:R-HSA-68962	3.83832488858e-05	0.5	RPA1 RPA4 RPA3	Activation of the pre-replicative complex
KEGG:03420	6.08868725508e-05	0.5	RPA1 RPA4 RPA3	Nucleotide excision repair
CORUM:2738	0.000170782642132	0.333333333333	RPA3 RPA1	BLM complex II
CORUM:2222	0.000170782642132	0.333333333333	RPA3 RPA1	BLM complex II
GO:0005657	0.000265438603659	0.666666666667	HMCES RPA1 RPA4 RPA3	replication fork
GO:0005662	0.000548960443183	0.5	RPA1 RPA4 RPA3	DNA replication factor A complex
CORUM:1004	0.000614368794823	0.333333333333	RPA3 RPA1	RC complex during S-phase of cell cycle
CORUM:248	0.000614368794823	0.333333333333	RPA3 RPA1	BRAFT complex
CORUM:1005	0.000767820823501	0.333333333333	RPA3 RPA1	RC complex during G2/M-phase of cell cycle
CORUM:244	0.000938276380634	0.333333333333	RPA3 RPA1	BRAFT complex
GO:0003697	0.00165931249978	0.666666666667	HMCES RPA1 RPA4 RPA3	single-stranded DNA binding
REAC:R-HSA-3371511	0.00170100530318	0.333333333333	RPA3 RPA1	HSF1 activation
REAC:R-HSA-69166	0.002344469338	0.333333333333	RPA3 RPA1	Removal of the Flap Intermediate
REAC:R-HSA-5358565	0.002344469338	0.333333333333	RPA3 RPA1	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
REAC:R-HSA-5358606	0.002344469338	0.333333333333	RPA3 RPA1	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
REAC:R-HSA-69206	0.00247941542207	0.5	RPA1 RPA4 RPA3	G1/S Transition
WP:WP531	0.00253948790052	0.333333333333	RPA3 RPA1	DNA mismatch repair
REAC:R-HSA-5358508	0.00270466310657	0.333333333333	RPA3 RPA1	Mismatch Repair
REAC:R-HSA-69183	0.00270466310657	0.333333333333	RPA3 RPA1	Processive synthesis on the lagging strand
GO:0043601	0.00295184433846	0.5	RPA1 RPA4 RPA3	nuclear replisome
REAC:R-HSA-5656121	0.00309047926945	0.333333333333	RPA3 RPA1	Translesion synthesis by POLI
REAC:R-HSA-110312	0.00309047926945	0.333333333333	RPA3 RPA1	Translesion synthesis by REV1
REAC:R-HSA-174437	0.0035019037522	0.333333333333	RPA3 RPA1	Removal of the Flap Intermediate from the C-strand
REAC:R-HSA-5655862	0.0035019037522	0.333333333333	RPA3 RPA1	Translesion synthesis by POLK
REAC:R-HSA-69002	0.00358509487789	0.5	RPA1 RPA4 RPA3	DNA Replication Pre-Initiation
REAC:R-HSA-453279	0.00358509487789	0.5	RPA1 RPA4 RPA3	Mitotic G1 phase and G1/S transition
GO:0030894	0.00387837112504	0.5	RPA1 RPA4 RPA3	replisome
REAC:R-HSA-110320	0.00440152140132	0.333333333333	RPA3 RPA1	Translesion Synthesis by POLH
REAC:R-HSA-174414	0.00440152140132	0.333333333333	RPA3 RPA1	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-69186	0.00488968644054	0.333333333333	RPA3 RPA1	Lagging Strand Synthesis
REAC:R-HSA-5651801	0.00540340354533	0.333333333333	RPA3 RPA1	PCNA-Dependent Long Patch Base Excision Repair
REAC:R-HSA-69306	0.0059397455674	0.5	RPA1 RPA4 RPA3	DNA Replication
HPA:0210053	0.00663723803136	0.833333333333	RPAIN HMCES RPA1 RPA4 RPA3	fallopian tube; glandular cells[High]
REAC:R-HSA-110373	0.00771351163082	0.333333333333	RPA3 RPA1	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REAC:R-HSA-5696397	0.00771351163082	0.333333333333	RPA3 RPA1	Gap-filling DNA repair synthesis and ligation in GG-NER
WP:WP4753	0.00903081201495	0.333333333333	RPA3 RPA1	Nucleotide excision repair
REAC:R-HSA-110314	0.0111743831709	0.333333333333	RPA3 RPA1	Recognition of DNA damage by PCNA-containing replication complex
REAC:R-HSA-5656169	0.0119428487471	0.333333333333	RPA3 RPA1	Termination of translesion DNA synthesis
REAC:R-HSA-69190	0.0127367120473	0.333333333333	RPA3 RPA1	DNA strand elongation
REAC:R-HSA-174417	0.0144005758041	0.333333333333	RPA3 RPA1	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-9709570	0.0144005758041	0.333333333333	RPA3 RPA1	Impaired BRCA2 binding to RAD51
REAC:R-HSA-6783310	0.0152705482636	0.333333333333	RPA3 RPA1	Fanconi Anemia Pathway
REAC:R-HSA-73933	0.0152705482636	0.333333333333	RPA3 RPA1	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-5685938	0.0152705482636	0.333333333333	RPA3 RPA1	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-176187	0.0161658624528	0.333333333333	RPA3 RPA1	Activation of ATR in response to replication stress
HPA:0610833	0.0169334987823	0.833333333333	RPAIN HMCES RPA1 RPA4 RPA3	urinary bladder; urothelial cells[High]
GO:0043596	0.017471616814	0.5	RPA1 RPA4 RPA3	nuclear replication fork
REAC:R-HSA-110313	0.0180324600743	0.333333333333	RPA3 RPA1	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-5693616	0.019003715544	0.333333333333	RPA3 RPA1	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9675136	0.0200002568185	0.333333333333	RPA3 RPA1	Diseases of DNA Double-Strand Break Repair
REAC:R-HSA-9701190	0.0200002568185	0.333333333333	RPA3 RPA1	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
WP:WP45	0.0200845776786	0.333333333333	RPA3 RPA1	G1 to S cell cycle control
REAC:R-HSA-5696400	0.0210220699274	0.333333333333	RPA3 RPA1	Dual Incision in GG-NER
REAC:R-HSA-5693579	0.0220691409046	0.333333333333	RPA3 RPA1	Homologous DNA Pairing and Strand Exchange
REAC:R-HSA-5696395	0.0220691409046	0.333333333333	RPA3 RPA1	Formation of Incision Complex in GG-NER
WP:WP5114	0.0261386321886	0.333333333333	RPA3 RPA1	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-73893	0.0276828753036	0.333333333333	RPA3 RPA1	DNA Damage Bypass
REAC:R-HSA-9675135	0.0301046858112	0.333333333333	RPA3 RPA1	Diseases of DNA repair
REAC:R-HSA-180786	0.0326270815028	0.333333333333	RPA3 RPA1	Extension of Telomeres
WP:WP2446	0.0362670507824	0.333333333333	RPA3 RPA1	Retinoblastoma gene in cancer
REAC:R-HSA-6782210	0.0498675109087	0.333333333333	RPA3 RPA1	Gap-filling DNA repair synthesis and ligation in TC-NER

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RPA3	RPA2	1.0	0.958	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
RPA1	RPA2	1.0	0.802		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
RPA3	RPA1	1.0	0.658	mutually_exclusive (Q13156)	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM
RPA1	RPAIN	0.999	0.196		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPA2	RPAIN	0.999	0.208		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPA1	RPA4	0.998		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPAIN	RPA4	0.997			bioplex3_WMM bioplex3_HCT116 WMM_only
RPA3	RPA4	0.995		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPA3	RPAIN	0.989	0.288		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HMCES	RPA1	0.988	0.08		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MACROD1	RPA2	0.978	0.026		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HMCES	RPA4	0.969			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HMCES	RPA2	0.965	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPA3	HMCES	0.957	0.072		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPA2	RPA4	0.931		mutually_exclusive (P35244)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MACROD1	RPA1	0.841	0.052		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MACROD1	RPA3	0.734	0.052	mutually_exclusive (P41208)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HMCES	RPAIN	0.643	0.034		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RPAIN	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
RPA4	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
MACROD1	huMAP3_01511.1 huMAP3_03503.1 huMAP3_07481.1 huMAP3_08422.1 huMAP3_08778.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13399.1 huMAP3_13854.1 huMAP3_14846.1
RPA2	huMAP3_03503.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
RPA3	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
HMCES	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13227.1 huMAP3_13854.1 huMAP3_14723.1
RPA1	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07481.1

Complex Portal: CPX-21163