hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07500.1
Complex Portal: CPX-17619
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
| ACTA1 | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | 5 | UniProt NCBI |
| ACTA2 | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 0.000672967801622 | 0.666666666667 | ACTA1 ACTA2 | Striated muscle contraction pathway |
| WP:WP4534 | 0.00088200834918 | 0.666666666667 | ACTA1 ACTA2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| HPA:0031323 | 0.00452496479488 | 0.666666666667 | ACTA1 ACTA2 | appendix; enterocytes - Microvilli[High] |
| HPA:0151323 | 0.00506795855783 | 0.666666666667 | ACTA1 ACTA2 | duodenum; enterocytes - Microvilli[High] |
| HPA:0131323 | 0.00506795855783 | 0.666666666667 | ACTA1 ACTA2 | colon; enterocytes - Microvilli[High] |
| HPA:0401323 | 0.00655950129524 | 0.666666666667 | ACTA1 ACTA2 | rectum; enterocytes - Microvilli[High] |
| HPA:0030433 | 0.00655950129524 | 0.666666666667 | ACTA1 ACTA2 | appendix; germinal center cells[High] |
| HPA:0481323 | 0.00754626791577 | 0.666666666667 | ACTA1 ACTA2 | small intestine; enterocytes - Microvilli[High] |
| HPA:0030443 | 0.00754626791577 | 0.666666666667 | ACTA1 ACTA2 | appendix; non-germinal center cells[High] |
| GO:0090131 | 0.00842684400117 | 0.666666666667 | ACTA1 ACTA2 | mesenchyme migration |
| WP:WP289 | 0.00958854810456 | 0.666666666667 | ACTA1 ACTA2 | Myometrial relaxation and contraction pathways |
| KEGG:04814 | 0.00988245105972 | 0.666666666667 | ACTA1 ACTA2 | Motor proteins |
| HPA:0031322 | 0.0168814200906 | 0.666666666667 | ACTA1 ACTA2 | appendix; enterocytes - Microvilli[>=Medium] |
| HPA:0151322 | 0.0187062482139 | 0.666666666667 | ACTA1 ACTA2 | duodenum; enterocytes - Microvilli[>=Medium] |
| HPA:0401322 | 0.0192447128164 | 0.666666666667 | ACTA1 ACTA2 | rectum; enterocytes - Microvilli[>=Medium] |
| HPA:0031321 | 0.0223418738472 | 0.666666666667 | ACTA1 ACTA2 | appendix; enterocytes - Microvilli[>=Low] |
| HPA:0131322 | 0.022929632408 | 0.666666666667 | ACTA1 ACTA2 | colon; enterocytes - Microvilli[>=Medium] |
| HPA:0401321 | 0.0241278746374 | 0.666666666667 | ACTA1 ACTA2 | rectum; enterocytes - Microvilli[>=Low] |
| HPA:0481322 | 0.0253564028883 | 0.666666666667 | ACTA1 ACTA2 | small intestine; enterocytes - Microvilli[>=Medium] |
| HPA:0151321 | 0.025982018976 | 0.666666666667 | ACTA1 ACTA2 | duodenum; enterocytes - Microvilli[>=Low] |
| HPA:0131321 | 0.0262976640836 | 0.666666666667 | ACTA1 ACTA2 | colon; enterocytes - Microvilli[>=Low] |
| HPA:0481321 | 0.0340788879073 | 0.666666666667 | ACTA1 ACTA2 | small intestine; enterocytes - Microvilli[>=Low] |
| HPA:0030432 | 0.0366451526634 | 0.666666666667 | ACTA1 ACTA2 | appendix; germinal center cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACTA2 | CAP1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| ACTA2 | ACTA1 | 0.985 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| CAP1 | ACTA1 | 0.985 | 0.34 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes