hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07502.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LAPTM4B | Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) | 5 | UniProt NCBI |
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | 5 | UniProt NCBI |
| PROKR1 | Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) | 4 | UniProt NCBI |
| UGCG | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | 5 | UniProt NCBI |
| GPR3 | G-protein coupled receptor 3 (ACCA orphan receptor) | 5 | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75158 | 0.000541723162524 | 0.333333333333 | TNFRSF10A TNFRSF10B | TRAIL signaling |
| REAC:R-HSA-5218900 | 0.00116019984728 | 0.333333333333 | TNFRSF10A TNFRSF10B | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 0.00116019984728 | 0.333333333333 | TNFRSF10A TNFRSF10B | Dimerization of procaspase-8 |
| REAC:R-HSA-3371378 | 0.00116019984728 | 0.333333333333 | TNFRSF10A TNFRSF10B | Regulation by c-FLIP |
| REAC:R-HSA-6803211 | 0.00170100530318 | 0.333333333333 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-140534 | 0.00200991204249 | 0.333333333333 | TNFRSF10A TNFRSF10B | Caspase activation via Death Receptors in the presence of ligand |
| REAC:R-HSA-5357769 | 0.00440152140132 | 0.333333333333 | TNFRSF10A TNFRSF10B | Caspase activation via extrinsic apoptotic signalling pathway |
| GO:0045569 | 0.00702301080125 | 0.333333333333 | TNFRSF10A TNFRSF10B | TRAIL binding |
| REAC:R-HSA-5675482 | 0.0111743831709 | 0.333333333333 | TNFRSF10A TNFRSF10B | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.0111743831709 | 0.333333333333 | TNFRSF10A TNFRSF10B | RIPK1-mediated regulated necrosis |
| KEGG:04061 | 0.0118953447518 | 0.333333333333 | TNFRSF10A TNFRSF10B | Viral protein interaction with cytokine and cytokine receptor |
| KEGG:04115 | 0.0144916673313 | 0.333333333333 | TNFRSF10A TNFRSF10B | p53 signaling pathway |
| REAC:R-HSA-5633008 | 0.0180324600743 | 0.333333333333 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Cell Death Genes |
| WP:WP1772 | 0.0298411603065 | 0.333333333333 | TNFRSF10A TNFRSF10B | Apoptosis modulation and signaling |
| REAC:R-HSA-5218859 | 0.0352499509777 | 0.333333333333 | TNFRSF10A TNFRSF10B | Regulated Necrosis |
| KEGG:04650 | 0.0419636118509 | 0.333333333333 | TNFRSF10A TNFRSF10B | Natural killer cell mediated cytotoxicity |
| WP:WP5322 | 0.0480201060929 | 0.333333333333 | TNFRSF10A TNFRSF10B | CKAP4 signaling pathway map |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TNFRSF10B | UGCG | 0.991 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TNFRSF10B | TNFRSF10A | 0.986 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TNFRSF10B | LAPTM4B | 0.97 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UGCG | LAPTM4B | 0.966 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| TNFRSF10B | PROKR1 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPR3 | TNFRSF10B | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TNFRSF10A | UGCG | 0.953 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TNFRSF10A | LAPTM4B | 0.449 | 0.1 | bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes