hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07510.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
VMA21	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	5	UniProt NCBI
ATP6V0D2	V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)	5	UniProt NCBI
ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	5	UniProt NCBI
TMEM199	Transmembrane protein 199	5	UniProt NCBI
ATP6V0A4	V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)	5	UniProt NCBI
CCDC115	Coiled-coil domain-containing protein 115	5	UniProt NCBI
SLC14A1	Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016471	4.96990184286e-09	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	vacuolar proton-transporting V-type ATPase complex
GO:0033176	6.34970501079e-09	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	proton-transporting V-type ATPase complex
GO:0007035	1.85352535413e-08	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	vacuolar acidification
GO:0051452	1.41123968224e-07	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	intracellular pH reduction
GO:0016469	2.04443040639e-07	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	proton-transporting two-sector ATPase complex
GO:0051453	1.02626003625e-06	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	regulation of intracellular pH
GO:0030641	1.21567269363e-06	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	regulation of cellular pH
GO:0006885	1.55120847681e-06	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	regulation of pH
KEGG:04966	6.19370988527e-06	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Collecting duct acid secretion
REAC:R-HSA-77387	4.24987071653e-05	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Insulin receptor recycling
REAC:R-HSA-917977	4.24987071653e-05	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Transferrin endocytosis and recycling
KEGG:05110	4.94026671671e-05	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Vibrio cholerae infection
WP:WP4917	5.52877610496e-05	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Proximal tubule transport
REAC:R-HSA-1222556	5.82765337859e-05	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	ROS and RNS production in phagocytes
GO:1904949	7.4871371327e-05	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	ATPase complex
KEGG:04721	0.000118770256621	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Synaptic vesicle cycle
KEGG:05120	0.000137743258265	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Epithelial cell signaling in Helicobacter pylori infection
KEGG:05323	0.000173655650743	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Rheumatoid arthritis
REAC:R-HSA-917937	0.000285286159018	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Iron uptake and transport
REAC:R-HSA-74752	0.000487210059522	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Signaling by Insulin receptor
KEGG:00190	0.00101170562286	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Oxidative phosphorylation
KEGG:04142	0.00103678431353	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Lysosome
KEGG:04145	0.00128120910497	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Phagosome
KEGG:05152	0.00173244468583	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Tuberculosis
GO:0005773	0.00213460737086	0.857142857143	VMA21 TMEM199 ATP6V0A4 ATP6V0D2 ATP6V0C CCDC115	vacuole
GO:0007042	0.0032492156641	0.428571428571	TMEM199 ATP6V0C CCDC115	lysosomal lumen acidification
REAC:R-HSA-983712	0.00394439973206	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Ion channel transport
GO:0030003	0.00414926758057	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	intracellular monoatomic cation homeostasis
GO:0006873	0.0043544898929	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	intracellular monoatomic ion homeostasis
HP:0010837	0.00598974417902	0.285714285714	TMEM199 CCDC115	Decreased circulating ceruloplasmin concentration
GO:0035751	0.00677983410628	0.428571428571	TMEM199 ATP6V0C CCDC115	regulation of lysosomal lumen pH
GO:0055080	0.00678684879394	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	monoatomic cation homeostasis
GO:0050801	0.00740393939261	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	monoatomic ion homeostasis
GO:0005774	0.00795161929058	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	vacuolar membrane
HP:0033144	0.00914682299331	0.285714285714	TMEM199 CCDC115	Abnormal circulating ceruloplasmin concentration
REAC:R-HSA-382551	0.0108683135939	0.571428571429	ATP6V0D2 SLC14A1 ATP6V0C ATP6V0A4	Transport of small molecules
KEGG:05165	0.013863027497	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	Human papillomavirus infection
GO:0055082	0.0146645400572	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	intracellular chemical homeostasis
GO:0019725	0.0353341016758	0.714285714286	ATP6V0D2 ATP6V0A4 ATP6V0C CCDC115 TMEM199	cellular homeostasis
GO:0030670	0.0383127531327	0.428571428571	ATP6V0D2 ATP6V0C ATP6V0A4	phagocytic vesicle membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
VMA21	ATP6V0D2	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	ATP6V0D2	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TMEM199	ATP6V0C	1.0	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
VMA21	TMEM199	1.0	0.04	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
ATP6V0D2	TMEM199	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	TMEM199	0.999	0.458	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
VMA21	ATP6V0C	0.999	0.052	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
ATP6V0D2	ATP6V0C	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	ATP6V0C	0.999	0.044	bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
CCDC115	ATP6V0A4	0.997	0.138	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
VMA21	CCDC115	0.994	0.092	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
VMA21	ATP6V0A4	0.994	0.056	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	TMEM199	0.985	0.058	bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	CCDC115	0.981	0.092	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	ATP6V0C	0.98	0.086	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	ATP6V0D2	0.972		bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	ATP6V0D2	0.972		bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	ATP6V0C	0.956	0.086	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	TMEM199	0.954	0.116	bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
VMA21	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
ATP6V0D2	huMAP3_01501.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0C	huMAP3_03313.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
TMEM199	huMAP3_01538.1 huMAP3_04056.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0A4	huMAP3_01342.1 huMAP3_01538.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CCDC115	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
SLC14A1	huMAP3_00361.1 huMAP3_00622.1 huMAP3_01538.1 huMAP3_04056.1 huMAP3_04243.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11123.1 huMAP3_12042.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07510.1