hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07537.1
Complex Portal: CPX-12854
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | 5 | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | 5 | UniProt NCBI |
| PITRM1 | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1) | 5 | UniProt NCBI |
| CCDC69 | Coiled-coil domain-containing protein 69 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9709603 | 0.00282403231951 | 0.5 | RMI2 TOP3A | Impaired BRCA2 binding to PALB2 |
| KEGG:03460 | 0.0029370300722 | 0.5 | RMI2 TOP3A | Fanconi anemia pathway |
| REAC:R-HSA-9704331 | 0.00306932002175 | 0.5 | RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 0.00306932002175 | 0.5 | RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 0.00306932002175 | 0.5 | RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9701193 | 0.00306932002175 | 0.5 | RMI2 TOP3A | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-5693554 | 0.00359044851421 | 0.5 | RMI2 TOP3A | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5693568 | 0.00539805716719 | 0.5 | RMI2 TOP3A | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-9709570 | 0.00573491177379 | 0.5 | RMI2 TOP3A | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5693537 | 0.00573491177379 | 0.5 | RMI2 TOP3A | Resolution of D-Loop Structures |
| REAC:R-HSA-5685938 | 0.006081926491 | 0.5 | RMI2 TOP3A | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 0.007571530532 | 0.5 | RMI2 TOP3A | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9675136 | 0.0079693038543 | 0.5 | RMI2 TOP3A | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 0.0079693038543 | 0.5 | RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5693579 | 0.008795277704 | 0.5 | RMI2 TOP3A | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 0.0120053783973 | 0.5 | RMI2 TOP3A | Diseases of DNA repair |
| GO:0031422 | 0.0168521501606 | 0.5 | RMI2 TOP3A | RecQ family helicase-topoisomerase III complex |
| REAC:R-HSA-5685942 | 0.0218635493976 | 0.5 | RMI2 TOP3A | HDR through Homologous Recombination (HRR) |
| WP:WP5381 | 0.0245369062383 | 0.5 | RMI2 TOP3A | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-69473 | 0.0380580405855 | 0.5 | RMI2 TOP3A | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 0.0398310607487 | 0.5 | RMI2 TOP3A | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.0407325822829 | 0.5 | RMI2 TOP3A | Processing of DNA double-strand break ends |
| GO:0071139 | 0.042122686785 | 0.5 | RMI2 TOP3A | resolution of DNA recombination intermediates |
| CORUM:2223 | 0.049938562206 | 0.25 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TOP3A | CCDC69 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RMI2 | TOP3A | 0.995 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RMI2 | CCDC69 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CCDC69 | PITRM1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TOP3A | PITRM1 | 0.274 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| RMI2 | PITRM1 | 0.048 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes