hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07537.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
RMI2	RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)	5	UniProt NCBI
TOP3A	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	5	UniProt NCBI
PITRM1	Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)	5	UniProt NCBI
CCDC69	Coiled-coil domain-containing protein 69	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9709603	0.00282403231951	0.5	RMI2 TOP3A	Impaired BRCA2 binding to PALB2
KEGG:03460	0.0029370300722	0.5	RMI2 TOP3A	Fanconi anemia pathway
REAC:R-HSA-9704331	0.00306932002175	0.5	RMI2 TOP3A	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
REAC:R-HSA-9704646	0.00306932002175	0.5	RMI2 TOP3A	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
REAC:R-HSA-9701192	0.00306932002175	0.5	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to BRCA1 loss of function
REAC:R-HSA-9701193	0.00306932002175	0.5	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to PALB2 loss of function
REAC:R-HSA-5693554	0.00359044851421	0.5	RMI2 TOP3A	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
REAC:R-HSA-5693568	0.00539805716719	0.5	RMI2 TOP3A	Resolution of D-loop Structures through Holliday Junction Intermediates
REAC:R-HSA-9709570	0.00573491177379	0.5	RMI2 TOP3A	Impaired BRCA2 binding to RAD51
REAC:R-HSA-5693537	0.00573491177379	0.5	RMI2 TOP3A	Resolution of D-Loop Structures
REAC:R-HSA-5685938	0.006081926491	0.5	RMI2 TOP3A	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-5693616	0.007571530532	0.5	RMI2 TOP3A	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9675136	0.0079693038543	0.5	RMI2 TOP3A	Diseases of DNA Double-Strand Break Repair
REAC:R-HSA-9701190	0.0079693038543	0.5	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
REAC:R-HSA-5693579	0.008795277704	0.5	RMI2 TOP3A	Homologous DNA Pairing and Strand Exchange
REAC:R-HSA-9675135	0.0120053783973	0.5	RMI2 TOP3A	Diseases of DNA repair
GO:0031422	0.0168521501606	0.5	RMI2 TOP3A	RecQ family helicase-topoisomerase III complex
REAC:R-HSA-5685942	0.0218635493976	0.5	RMI2 TOP3A	HDR through Homologous Recombination (HRR)
WP:WP5381	0.0245369062383	0.5	RMI2 TOP3A	Smith Magenis and Potocki Lupski syndrome copy number variation
REAC:R-HSA-69473	0.0380580405855	0.5	RMI2 TOP3A	G2/M DNA damage checkpoint
REAC:R-HSA-6804756	0.0398310607487	0.5	RMI2 TOP3A	Regulation of TP53 Activity through Phosphorylation
REAC:R-HSA-5693607	0.0407325822829	0.5	RMI2 TOP3A	Processing of DNA double-strand break ends
GO:0071139	0.042122686785	0.5	RMI2 TOP3A	resolution of DNA recombination intermediates
CORUM:2223	0.049938562206	0.25	TOP3A	BLM-TOP3A complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TOP3A	CCDC69	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RMI2	TOP3A	0.995	0.162	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RMI2	CCDC69	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CCDC69	PITRM1	0.991		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TOP3A	PITRM1	0.274	0.072	bioplex_WMM bioplex3_WMM WMM_only
RMI2	PITRM1	0.048	0.048	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RMI2	huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1
TOP3A	huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1
PITRM1	huMAP3_01456.1 huMAP3_02777.1 huMAP3_05361.1 huMAP3_06415.1 huMAP3_07537.1 huMAP3_11170.1 huMAP3_11377.1 huMAP3_11473.1 huMAP3_12936.1 huMAP3_15110.1
CCDC69	huMAP3_00733.1 huMAP3_01218.1 huMAP3_07537.1 huMAP3_13411.1 huMAP3_13908.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07537.1