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hu.MAP 3.0
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hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):
Enrichment (ex. cilium):
Protein (ex. Centrosomal protein):
Complex:
huMAP3_07537.1
Complex Portal:
CPX-12854
Confidence:
Very High
?
Proteins
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Genename
Protein Name
Uniprot Annotation Score
Links
CCDC69
Coiled-coil domain-containing protein 69
4
UniProt
NCBI
PITRM1
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
5
UniProt
NCBI
RMI2
RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)
5
UniProt
NCBI
TOP3A
DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)
5
UniProt
NCBI
Showing 1 to 4 of 4 entries
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Enrichments
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Term ID
Corrected Pval
Fraction Complex Coverage
Proteins
Term Name
REAC:R-HSA-9709603
0.00282403231951
0.5
TOP3A RMI2
Impaired BRCA2 binding to PALB2
KEGG:03460
0.0029370300722
0.5
TOP3A RMI2
Fanconi anemia pathway
REAC:R-HSA-9704331
0.00306932002175
0.5
TOP3A RMI2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
REAC:R-HSA-9704646
0.00306932002175
0.5
TOP3A RMI2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
REAC:R-HSA-9701192
0.00306932002175
0.5
TOP3A RMI2
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
REAC:R-HSA-9701193
0.00306932002175
0.5
TOP3A RMI2
Defective homologous recombination repair (HRR) due to PALB2 loss of function
REAC:R-HSA-5693554
0.00359044851421
0.5
TOP3A RMI2
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
REAC:R-HSA-5693568
0.00539805716719
0.5
TOP3A RMI2
Resolution of D-loop Structures through Holliday Junction Intermediates
REAC:R-HSA-9709570
0.00573491177379
0.5
TOP3A RMI2
Impaired BRCA2 binding to RAD51
REAC:R-HSA-5693537
0.00573491177379
0.5
TOP3A RMI2
Resolution of D-Loop Structures
Showing 1 to 10 of 24 entries
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Edges
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Protein 1
Protein 2
Score
?
ProteomeHD
?
Interface Overlap
?
Evidence
?
TOP3A
CCDC69
0.999
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RMI2
TOP3A
0.995
0.162
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RMI2
CCDC69
0.993
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CCDC69
PITRM1
0.991
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TOP3A
PITRM1
0.274
0.072
bioplex_WMM bioplex3_WMM WMM_only
RMI2
PITRM1
0.048
0.048
bioplex_WMM bioplex3_WMM WMM_only
Showing 1 to 6 of 6 entries
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Related Complexes
Genename
Complexes
RMI2
huMAP3_00733.1
huMAP3_01218.1
huMAP3_04213.1
huMAP3_07537.1
TOP3A
huMAP3_00733.1
huMAP3_01218.1
huMAP3_04213.1
huMAP3_07537.1
PITRM1
huMAP3_01456.1
huMAP3_02777.1
huMAP3_05361.1
huMAP3_06415.1
huMAP3_07537.1
huMAP3_11170.1
huMAP3_11377.1
huMAP3_11473.1
huMAP3_12936.1
huMAP3_15110.1
CCDC69
huMAP3_00733.1
huMAP3_01218.1
huMAP3_07537.1
huMAP3_13411.1
huMAP3_13908.1