hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07541.1

Complex Portal: CPX-25515

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
GDPD1	Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)	5	UniProt NCBI
UBE2U	Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)	5	UniProt NCBI
APCS	Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]	5	UniProt NCBI
SAA2	Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)]	5	UniProt NCBI
HPR	Haptoglobin-related protein	5	UniProt NCBI
APOC3	Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)	5	UniProt NCBI
F2	Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]	5	UniProt NCBI
KNG1	Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]	5	UniProt NCBI
MATN2	Matrilin-2	5	UniProt NCBI
FGG	Fibrinogen gamma chain	5	UniProt NCBI
P2RX6	P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1)	5	UniProt NCBI
C4BPA	C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)	5	UniProt NCBI
ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)	5	UniProt NCBI
SAA4	Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA)	4	UniProt NCBI
ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP)	5	UniProt NCBI
A2M	Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)	5	UniProt NCBI
C5	Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]	5	UniProt NCBI
GPX3	Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)	5	UniProt NCBI
PHF11	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0072562	4.17341745337e-09	0.470588235294	ITIH2 A2M C4BPA KNG1 F2 APCS HPR FGG	blood microparticle
KEGG:04610	7.58105852804e-09	0.352941176471	A2M C4BPA KNG1 C5 F2 FGG	Complement and coagulation cascades
REAC:R-HSA-140877	1.24705294159e-05	0.235294117647	F2 A2M KNG1 FGG	Formation of Fibrin Clot (Clotting Cascade)
GO:0062023	3.05292595437e-05	0.470588235294	ITIH2 MATN2 APOC3 KNG1 F2 APCS A2M FGG	collagen-containing extracellular matrix
WP:WP176	4.68091886874e-05	0.235294117647	F2 SAA2 SAA4 FGG	Folate metabolism
WP:WP15	0.000110741434116	0.235294117647	F2 SAA2 SAA4 FGG	Selenium micronutrient network
GO:0030312	0.000152574596952	0.470588235294	ITIH2 MATN2 APOC3 KNG1 F2 APCS A2M FGG	external encapsulating structure
GO:0031012	0.000152574596952	0.470588235294	ITIH2 MATN2 APOC3 KNG1 F2 APCS A2M FGG	extracellular matrix
WP:WP2806	0.000182842925825	0.235294117647	APCS C5 FGG C4BPA	Complement system
REAC:R-HSA-140837	0.000474885036295	0.176470588235	F2 KNG1 A2M	Intrinsic Pathway of Fibrin Clot Formation
REAC:R-HSA-381426	0.0014794701255	0.235294117647	ITIH2 F2 KNG1 FGG	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP:WP1533	0.00165819308905	0.176470588235	F2 SAA2 SAA4	Vitamin B12 metabolism
WP:WP4927	0.00216481322863	0.117647058824	F2 FGG	COVID 19 thrombosis and anticoagulation
KEGG:04080	0.00327032022377	0.235294117647	F2 C5 KNG1 P2RX6	Neuroactive ligand-receptor interaction
REAC:R-HSA-977606	0.0043740492022	0.176470588235	F2 C5 C4BPA	Regulation of Complement cascade
REAC:R-HSA-166658	0.00706132527493	0.176470588235	F2 C5 C4BPA	Complement cascade
WP:WP4493	0.0112032282492	0.117647058824	C5 KNG1	Cells and molecules involved in local acute inflammatory response
GO:0032102	0.014011792852	0.352941176471	A2M KNG1 C5 APCS F2 FGG	negative regulation of response to external stimulus
GO:0061045	0.0151343651472	0.235294117647	APCS KNG1 FGG F2	negative regulation of wound healing
WP:WP272	0.0219005077051	0.117647058824	F2 FGG	Blood clotting cascade
HP:0011884	0.0289698372489	0.117647058824	F2 FGG	Abnormal umbilical stump bleeding
REAC:R-HSA-76002	0.0311823400003	0.235294117647	F2 A2M KNG1 FGG	Platelet activation, signaling and aggregation
GO:0070062	0.0347955553839	0.647058823529	ITIH2 SAA4 C5 APOC3 SAA2 KNG1 F2 APCS A2M HPR FGG	extracellular exosome
KEGG:05143	0.0350148205067	0.117647058824	HPR KNG1	African trypanosomiasis
GO:1903035	0.0381243876392	0.235294117647	APCS KNG1 FGG F2	negative regulation of response to wounding
GO:1903561	0.0382533225132	0.647058823529	ITIH2 SAA4 C5 APOC3 SAA2 KNG1 F2 APCS A2M HPR FGG	extracellular vesicle
GO:0043230	0.0384659653361	0.647058823529	ITIH2 SAA4 C5 APOC3 SAA2 KNG1 F2 APCS A2M HPR FGG	extracellular organelle
GO:0065010	0.0384659653361	0.647058823529	ITIH2 SAA4 C5 APOC3 SAA2 KNG1 F2 APCS A2M HPR FGG	extracellular membrane-bounded organelle
REAC:R-HSA-8957275	0.0420770759522	0.176470588235	ITIH2 KNG1 FGG	Post-translational protein phosphorylation
REAC:R-HSA-8963898	0.0488269140913	0.117647058824	APOC3 A2M	Plasma lipoprotein assembly
HP:0030137	0.0495946438232	0.117647058824	F2 FGG	Prolonged bleeding following circumcision

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
UBE2U	SAA4	0.999
C5	UBE2U	0.998
F2	P2RX6	0.998
C5	PHF11	0.998
UBE2U	SAA2	0.997
PHF11	GPX3	0.997
ITIH1	PHF11	0.997
UBE2U	ITIH1	0.997
C4BPA	PHF11	0.997
GPX3	A2M	0.997	0.37
PHF11	HPR	0.997
F2	UBE2U	0.997
PHF11	APCS	0.996
APOC3	UBE2U	0.995
KNG1	PHF11	0.994
UBE2U	KNG1	0.994
UBE2U	APCS	0.993
MATN2	APCS	0.992	0.09
UBE2U	C4BPA	0.991
P2RX6	ITIH2	0.991		structurally_consistent (dimer)
MATN2	HPR	0.987
ITIH1	MATN2	0.982	0.08
ITIH2	PHF11	0.978
UBE2U	ITIH2	0.978
APOC3	MATN2	0.974	0.216
KNG1	A2M	0.973
PHF11	A2M	0.972
UBE2U	A2M	0.972
UBE2U	FGG	0.97
A2M	GDPD1	0.967	0.174
P2RX6	A2M	0.959		structurally_consistent (dimer)
FGG	PHF11	0.957
KNG1	ITIH2	0.951
APOC3	ITIH2	0.949	0.224
MATN2	A2M	0.946	0.15
MATN2	ITIH2	0.939	0.14
ITIH2	GDPD1	0.923	0.098
APOC3	GDPD1	0.918	0.166	structurally_consistent (dimer)
ITIH1	APCS	0.905	0.404
SAA2	SAA4	0.902
C4BPA	A2M	0.87	0.19
P2RX6	FGG	0.865
ITIH1	C4BPA	0.828	0.272
APOC3	A2M	0.811	0.45
HPR	APCS	0.784
C4BPA	HPR	0.783
C4BPA	APCS	0.77	0.23	structurally_consistent (dimer)
FGG	APCS	0.765	0.398
ITIH2	C4BPA	0.763	0.248
FGG	C4BPA	0.76	0.18
SAA4	HPR	0.722
F2	A2M	0.718	0.186
ITIH1	FGG	0.698	0.454
FGG	A2M	0.694	0.504
A2M	APCS	0.69	0.387333333333
F2	SAA4	0.688
FGG	HPR	0.667
ITIH1	HPR	0.667
APOC3	SAA4	0.656
APOC3	ITIH1	0.649	0.338
APOC3	APCS	0.649	0.38
ITIH1	A2M	0.642	0.524
ITIH1	ITIH2	0.636	0.244
F2	GPX3	0.634	0.41
SAA4	ITIH2	0.634
SAA4	FGG	0.634
KNG1	HPR	0.634
SAA4	C4BPA	0.633
SAA4	KNG1	0.633
C5	HPR	0.633
SAA4	ITIH1	0.633
SAA4	A2M	0.633
KNG1	GDPD1	0.627
C5	SAA4	0.616
HPR	A2M	0.615
ITIH2	HPR	0.615
ITIH2	APCS	0.599	0.2
F2	FGG	0.573	0.316
APOC3	KNG1	0.567
C5	ITIH1	0.534	0.468
C5	C4BPA	0.534	0.236
KNG1	C4BPA	0.532
ITIH2	A2M	0.507	0.446
ITIH1	KNG1	0.497
KNG1	APCS	0.497
APOC3	SAA2	0.474
F2	SAA2	0.468
C5	SAA2	0.468
C5	KNG1	0.455
ITIH2	FGG	0.448	0.25
SAA4	APCS	0.445
C5	A2M	0.441	0.238113207547
ITIH1	GPX3	0.438	0.22
GPX3	APCS	0.438
C4BPA	GPX3	0.438	0.18
C5	APCS	0.438	0.516
C5	FGG	0.438	0.248
C5	ITIH2	0.422	0.348529411765
SAA2	ITIH1	0.418
SAA2	C4BPA	0.418
KNG1	GPX3	0.404
GPX3	HPR	0.401
SAA2	APCS	0.396
F2	C4BPA	0.384	0.32
F2	ITIH1	0.384	0.53
F2	KNG1	0.384
F2	APCS	0.384	0.436528409091
KNG1	FGG	0.369
F2	C5	0.366	0.474
C5	GPX3	0.366	0.176
ITIH2	GPX3	0.346	0.168
F2	ITIH2	0.346	0.272
APOC3	C5	0.335	0.404
F2	APOC3	0.335	0.6
APOC3	HPR	0.323
APOC3	C4BPA	0.314	0.328
FGG	GPX3	0.258	0.37
SAA2	KNG1	0.255
SAA2	A2M	0.21
SAA2	FGG	0.175
SAA2	ITIH2	0.157
APOC3	FGG	0.123	0.44
MATN2	FGG	0.029	0.118

Related Complexes

Genename	Complexes
GDPD1	huMAP3_07265.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
UBE2U	huMAP3_00178.1 huMAP3_03086.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07611.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_14322.1 huMAP3_15040.1
APCS	huMAP3_07064.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08049.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_09846.1 huMAP3_10101.1 huMAP3_15040.1
SAA2	huMAP3_00178.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_13054.1 huMAP3_14041.1 huMAP3_14322.1 huMAP3_14675.1
HPR	huMAP3_03564.1 huMAP3_06018.1 huMAP3_07541.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_08450.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_14295.1
APOC3	huMAP3_00178.1 huMAP3_00961.1 huMAP3_04159.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10004.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_15040.1
F2	huMAP3_00074.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08218.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1
KNG1	huMAP3_02236.1 huMAP3_07265.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
MATN2	huMAP3_00961.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07647.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_11307.1 huMAP3_15040.1
FGG	huMAP3_02242.1 huMAP3_07541.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
P2RX6	huMAP3_00341.1 huMAP3_07541.1 huMAP3_07611.1 huMAP3_07701.1 huMAP3_08218.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10501.1 huMAP3_10678.1 huMAP3_15040.1
C4BPA	huMAP3_02768.1 huMAP3_02811.1 huMAP3_03086.1 huMAP3_06454.1 huMAP3_07376.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08139.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
ITIH2	huMAP3_02236.1 huMAP3_07265.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_14338.1 huMAP3_15040.1
SAA4	huMAP3_00178.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_14295.1
ITIH1	huMAP3_00178.1 huMAP3_00961.1 huMAP3_02811.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_15040.1
A2M	huMAP3_04676.1 huMAP3_07265.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_11290.1 huMAP3_15040.1
C5	huMAP3_00178.1 huMAP3_02811.1 huMAP3_05922.1 huMAP3_06499.1 huMAP3_07119.1 huMAP3_07376.1 huMAP3_07541.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1
GPX3	huMAP3_03255.1 huMAP3_04676.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_14537.1
PHF11	huMAP3_02811.1 huMAP3_03255.1 huMAP3_05922.1 huMAP3_06499.1 huMAP3_07376.1 huMAP3_07541.1 huMAP3_07611.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07541.1

Complex Portal: CPX-25515