hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07547.1
Complex Portal: CPX-21956
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARL3 | ADP-ribosylation factor-like protein 3 | 5 | UniProt NCBI |
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| TBC1D10A | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 4.09448956317e-05 | 0.4 | INPP5E PDE6D | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 4.55977246808e-05 | 0.4 | INPP5E PDE6D | ARL13B-mediated ciliary trafficking of INPP5E |
| REAC:R-HSA-5620920 | 4.71645743242e-05 | 0.6 | INPP5E ARL3 PDE6D | Cargo trafficking to the periciliary membrane |
| WP:WP4656 | 6.85359532624e-05 | 0.6 | INPP5E ARL3 PDE6D | Joubert syndrome |
| HP:0002419 | 7.85415640073e-05 | 0.6 | INPP5E ARL3 PDE6D | Molar tooth sign on MRI |
| WP:WP5234 | 8.42550380506e-05 | 0.6 | INPP5E ARL3 PDE6D | Bardet Biedl syndrome |
| HP:0002876 | 0.000241447043353 | 0.6 | INPP5E ARL3 PDE6D | Episodic tachypnea |
| HP:0004422 | 0.00038313758832 | 0.6 | INPP5E ARL3 PDE6D | Biparietal narrowing |
| HP:0002418 | 0.000685212767946 | 0.6 | INPP5E ARL3 PDE6D | Abnormal midbrain morphology |
| WP:WP4803 | 0.000737700711921 | 0.6 | INPP5E ARL3 PDE6D | Ciliopathies |
| HP:0002789 | 0.00119989499053 | 0.6 | INPP5E ARL3 PDE6D | Tachypnea |
| HP:0001696 | 0.00169289796817 | 0.6 | INPP5E ARL3 PDE6D | Situs inversus totalis |
| HP:0011534 | 0.00180535854106 | 0.6 | INPP5E ARL3 PDE6D | Abnormal spatial orientation of the cardiac segments |
| HP:0000657 | 0.00198318736699 | 0.6 | INPP5E ARL3 PDE6D | Oculomotor apraxia |
| HP:0011933 | 0.00230672366147 | 0.4 | INPP5E ARL3 | Elongated superior cerebellar peduncle |
| HP:0011815 | 0.00237299419328 | 0.6 | INPP5E ARL3 PDE6D | Cephalocele |
| HP:0002084 | 0.00237299419328 | 0.6 | INPP5E ARL3 PDE6D | Encephalocele |
| HP:0011932 | 0.00288300984678 | 0.4 | INPP5E ARL3 | Abnormal superior cerebellar peduncle morphology |
| HP:0001651 | 0.00288838076992 | 0.6 | INPP5E ARL3 PDE6D | Dextrocardia |
| HP:0004307 | 0.00296757123606 | 0.6 | INPP5E ARL3 PDE6D | Abnormal anatomic location of the heart |
| HP:0001829 | 0.00338520553001 | 0.6 | INPP5E ARL3 PDE6D | Foot polydactyly |
| REAC:R-HSA-5617833 | 0.0033903418593 | 0.6 | INPP5E ARL3 PDE6D | Cilium Assembly |
| HP:0009136 | 0.00374608473288 | 0.6 | INPP5E ARL3 PDE6D | Duplication involving bones of the feet |
| HP:0011931 | 0.00422725674544 | 0.4 | INPP5E ARL3 | Abnormal cerebellar peduncle morphology |
| HP:0034237 | 0.00433390348683 | 0.6 | INPP5E ARL3 PDE6D | Open neural tube defect |
| HP:0004362 | 0.00497992365102 | 0.6 | INPP5E ARL3 PDE6D | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.00497992365102 | 0.6 | INPP5E ARL3 PDE6D | Aganglionic megacolon |
| HP:0002335 | 0.00499516489297 | 0.4 | INPP5E PDE6D | Agenesis of cerebellar vermis |
| HP:0012501 | 0.00499516489297 | 0.4 | INPP5E ARL3 | Abnormal brainstem white matter morphology |
| HP:0025028 | 0.00509344150575 | 0.6 | INPP5E ARL3 PDE6D | Abnormal enteric nervous system morphology |
| HP:0012331 | 0.00509344150575 | 0.6 | INPP5E ARL3 PDE6D | Abnormal autonomic nervous system morphology |
| HP:0001161 | 0.00819982205473 | 0.6 | INPP5E ARL3 PDE6D | Hand polydactyly |
| HP:0000612 | 0.00884324759031 | 0.6 | INPP5E ARL3 PDE6D | Iris coloboma |
| REAC:R-HSA-1852241 | 0.0104028281978 | 0.6 | INPP5E ARL3 PDE6D | Organelle biogenesis and maintenance |
| HP:0002553 | 0.0119511781956 | 0.6 | INPP5E ARL3 PDE6D | Highly arched eyebrow |
| HP:0002126 | 0.0121536331541 | 0.6 | INPP5E ARL3 PDE6D | Polymicrogyria |
| HP:0002186 | 0.0140788593896 | 0.6 | INPP5E ARL3 PDE6D | Apraxia |
| HP:0007973 | 0.0176485923371 | 0.4 | INPP5E PDE6D | Retinal dysplasia |
| HP:0009997 | 0.0179809507844 | 0.6 | INPP5E ARL3 PDE6D | Duplication of phalanx of hand |
| HP:0004275 | 0.0182461031555 | 0.6 | INPP5E ARL3 PDE6D | Duplication of hand bones |
| HP:0009142 | 0.0182461031555 | 0.6 | INPP5E ARL3 PDE6D | Duplication of bones involving the upper extremities |
| HP:0002104 | 0.0185138307015 | 0.6 | INPP5E ARL3 PDE6D | Apnea |
| HP:0000426 | 0.0193325851576 | 0.6 | INPP5E ARL3 PDE6D | Prominent nasal bridge |
| HP:0000589 | 0.0231575360078 | 0.6 | INPP5E ARL3 PDE6D | Coloboma |
| HP:0010442 | 0.0254100289024 | 0.6 | INPP5E ARL3 PDE6D | Polydactyly |
| HP:0000276 | 0.0257431724127 | 0.6 | INPP5E ARL3 PDE6D | Long face |
| WP:WP4536 | 0.0275912236597 | 0.4 | INPP5E ARL3 | Genes related to primary cilium development based on CRISPR |
| HP:0100729 | 0.0342232629352 | 0.6 | INPP5E ARL3 PDE6D | Large face |
| HP:0002270 | 0.0346287076763 | 0.6 | INPP5E ARL3 PDE6D | Abnormality of the autonomic nervous system |
| HP:0001320 | 0.0346287076763 | 0.6 | INPP5E ARL3 PDE6D | Cerebellar vermis hypoplasia |
| HP:0045005 | 0.0375559878492 | 0.6 | INPP5E ARL3 PDE6D | Neural tube defect |
| HP:0410043 | 0.0375559878492 | 0.6 | INPP5E ARL3 PDE6D | Abnormal neural tube morphology |
| HP:0006817 | 0.044850219801 | 0.6 | INPP5E ARL3 PDE6D | Aplasia/Hypoplasia of the cerebellar vermis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE6D | INPP5E | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | FBXO10 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE6D | TBC1D10A | 0.997 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ARL3 | PDE6D | 0.985 | 0.282 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| TBC1D10A | INPP5E | 0.931 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| FBXO10 | TBC1D10A | 0.77 | bioplex3_WMM WMM_only | ||
| FBXO10 | INPP5E | 0.757 | bioplex3_WMM WMM_only | ||
| ARL3 | INPP5E | 0.676 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| ARL3 | TBC1D10A | 0.656 | 0.05 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | FBXO10 | 0.602 | 0.118 | bioplex3_WMM WMM_only |
Related Complexes